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Ivermectin

伊维菌素,伊维菌素,MK-933,MK 933,MK933

Ivermectin是广谱的抗寄生虫化合物,是α7神经元烟碱乙酰胆碱受体和P2X4受体阳性变构调节剂。

目录号
EY0447
EY0447
纯度
99.28%
99.28%
规格
100 mg
500 mg
原价
160.00
480.00
售价
160.00
480.00
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Wagstaff KM, et al. Biochem J, 2012, 443(3), 851-856.
    [2] Krause, R.M., et al. 1998. Mol.Pharmacol. 53: 283-294.
    [3] Adelsberger, H., et al. 2000. Eur. J. Pharmacol. 394: 163-170.
    [4] Shan, Q., et al. 2001. J. Biol. Chem. 276: 12556-12564.

    分子式
    C95H146O28
    分子量
    1736.16
    CAS号
    70288-86-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    175 mg/mL
    Water
    <1 mg/mL
    Ethanol
    30 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02806414 Rosacea Drug: Ivermectin University of California, San Diego|Galderma Phase 1|Phase 2 2016-07-01 2016-06-17
    NCT02036229 Demodicidosis|Rosacea Drug: ivermectin cream 0.5% Rabin Medical Center Phase 3 2014-02-01 2015-01-10
    NCT02784743 Lymphatic Filariasis Drug: ''albendazole'' and ''ivermectin'' Centre d'Appui 脿 la lutte contre la Maladie|Malaria Research and Training Center, Bamako, Mali|World Health Organization Phase 4 2001-05-01 2016-05-24
    NCT00921219 Healthy Drug: ivermectin Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2005-09-01 2011-10-04
    NCT00921154 Healthy Drug: ivermectin Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2005-03-01 2011-10-04
    NCT00921674 Healthy Drug: ivermectin Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2005-02-01 2011-10-04
    NCT02963324 Malaria Drug: Ivermectin University Hospital, Basel, Switzerland Phase 1 2016-11-01 2017-01-31
    NCT01570504 Strongyloidiasis Drug: Ivermectin Centro per le Malattie Tropicali|European Commission Phase 3 2013-03-01 2016-08-05
    NCT00790998 Onchocerciasis Drug: Moxidectin|Drug: Ivermectin World Health Organization Phase 3 2009-04-01 2013-11-26
    NCT03052998 Ivermectin|Onchocerciasis|Epilepsy Drug: Ivermectin Robert Colebunders|Universiteit Antwerpen Phase 4 2017-04-01 2017-02-15
    NCT02046200 Alcohol Use Disorder Drug: Ivermectin|Drug: Placebo|Drug: Alcohol University of California, Los Angeles Phase 1|Phase 2 2014-02-01 2016-02-19
    NCT00765024 Chronic Strongyloidiasis Drug: Ivermectin|Drug: ivermectin|Drug: Albendazole Mahidol University|Atlantic Laboratory Ltd Phase 3 2008-07-01 2010-06-18
    NCT01068158 Head Lice Drug: 0.5% Ivermectin Cream|Drug: Placebo control Topaz Pharmaceuticals Inc Phase 3 2010-03-01 2012-04-04
    NCT00857948 Pediculus Humanus Capitis (Head Lice) Drug: ivermectin treatment conditioner|Drug: Placebo, vehicle control Topaz Pharmaceuticals Inc Phase 2 2009-03-01 2012-03-01
    NCT00819520 Lice Infestations Drug: ivermectin|Drug: malathion Johnson & Johnson Consumer and Personal Products Worldwide Phase 3 2004-02-01 2011-08-19
    NCT01066585 Head Lice Drug: Ivermectin Cream|Drug: vehicle control Topaz Pharmaceuticals Inc Phase 3 2010-03-01 2012-04-04
    NCT02509481 Malaria|Lymphatic Filariasis Drug: Ivermectin|Drug: Albendazole Colorado State University|Institut de Recherche en Sciences de la Sante, Burkina Faso|Centre Muraz|Minist猫re de la Sant茅 du Burkina Faso Phase 2|Phase 3 2015-06-01 2016-08-22
    NCT01593722 Loiasis Drug: Diethylcarbamazine|Drug: Ivermectin National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) Phase 4 2012-04-01 2016-09-20
    NCT00994422 Head Lice Drug: Ivermectin cream|Drug: vehicle control Topaz Pharmaceuticals Inc Phase 2 2009-10-01 2012-04-04
    NCT02045069 Dengue Fever Drug: 2 days Ivermectin|Drug: 3 days Ivermectin|Drug: Placebo Mahidol University|Ministry of Health, Thailand Phase 2|Phase 3 2014-02-01 2015-10-29
    NCT02511353 Malaria Drug: ivermectin|Drug: placebo|Drug: dihydroartemisinin-piperaquine Liverpool School of Tropical Medicine|Kenya Medical Research Institute|Centers for Disease Control and Prevention Phase 2 2015-07-01 2016-09-06
    NCT02407782 Scabies Drug: Ivermectin|Drug: Permethrin University Hospital, Bordeaux Phase 3 2016-01-01 2016-06-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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