Ivermectin是广谱的抗寄生虫化合物,是α7神经元烟碱乙酰胆碱受体和P2X4受体阳性变构调节剂。
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Wagstaff KM, et al. Biochem J, 2012, 443(3), 851-856.
[2] Krause, R.M., et al. 1998. Mol.Pharmacol. 53: 283-294.
[3] Adelsberger, H., et al. 2000. Eur. J. Pharmacol. 394: 163-170.
[4] Shan, Q., et al. 2001. J. Biol. Chem. 276: 12556-12564.
分子式 C95H146O28 |
分子量 1736.16 |
CAS号 70288-86-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 175 mg/mL |
Water <1 mg/mL |
Ethanol 30 mg/mL |
体内溶解度
NCT02806414 | Rosacea | Drug: Ivermectin | University of California, San Diego|Galderma | Phase 1|Phase 2 | 2016-07-01 | 2016-06-17 |
NCT02036229 | Demodicidosis|Rosacea | Drug: ivermectin cream 0.5% | Rabin Medical Center | Phase 3 | 2014-02-01 | 2015-01-10 |
NCT02784743 | Lymphatic Filariasis | Drug: ''albendazole'' and ''ivermectin'' | Centre d'Appui 脿 la lutte contre la Maladie|Malaria Research and Training Center, Bamako, Mali|World Health Organization | Phase 4 | 2001-05-01 | 2016-05-24 |
NCT00921219 | Healthy | Drug: ivermectin | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 1 | 2005-09-01 | 2011-10-04 |
NCT00921154 | Healthy | Drug: ivermectin | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 1 | 2005-03-01 | 2011-10-04 |
NCT00921674 | Healthy | Drug: ivermectin | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 1 | 2005-02-01 | 2011-10-04 |
NCT02963324 | Malaria | Drug: Ivermectin | University Hospital, Basel, Switzerland | Phase 1 | 2016-11-01 | 2017-01-31 |
NCT01570504 | Strongyloidiasis | Drug: Ivermectin | Centro per le Malattie Tropicali|European Commission | Phase 3 | 2013-03-01 | 2016-08-05 |
NCT00790998 | Onchocerciasis | Drug: Moxidectin|Drug: Ivermectin | World Health Organization | Phase 3 | 2009-04-01 | 2013-11-26 |
NCT03052998 | Ivermectin|Onchocerciasis|Epilepsy | Drug: Ivermectin | Robert Colebunders|Universiteit Antwerpen | Phase 4 | 2017-04-01 | 2017-02-15 |
NCT02046200 | Alcohol Use Disorder | Drug: Ivermectin|Drug: Placebo|Drug: Alcohol | University of California, Los Angeles | Phase 1|Phase 2 | 2014-02-01 | 2016-02-19 |
NCT00765024 | Chronic Strongyloidiasis | Drug: Ivermectin|Drug: ivermectin|Drug: Albendazole | Mahidol University|Atlantic Laboratory Ltd | Phase 3 | 2008-07-01 | 2010-06-18 |
NCT01068158 | Head Lice | Drug: 0.5% Ivermectin Cream|Drug: Placebo control | Topaz Pharmaceuticals Inc | Phase 3 | 2010-03-01 | 2012-04-04 |
NCT00857948 | Pediculus Humanus Capitis (Head Lice) | Drug: ivermectin treatment conditioner|Drug: Placebo, vehicle control | Topaz Pharmaceuticals Inc | Phase 2 | 2009-03-01 | 2012-03-01 |
NCT00819520 | Lice Infestations | Drug: ivermectin|Drug: malathion | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 3 | 2004-02-01 | 2011-08-19 |
NCT01066585 | Head Lice | Drug: Ivermectin Cream|Drug: vehicle control | Topaz Pharmaceuticals Inc | Phase 3 | 2010-03-01 | 2012-04-04 |
NCT02509481 | Malaria|Lymphatic Filariasis | Drug: Ivermectin|Drug: Albendazole | Colorado State University|Institut de Recherche en Sciences de la Sante, Burkina Faso|Centre Muraz|Minist猫re de la Sant茅 du Burkina Faso | Phase 2|Phase 3 | 2015-06-01 | 2016-08-22 |
NCT01593722 | Loiasis | Drug: Diethylcarbamazine|Drug: Ivermectin | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | Phase 4 | 2012-04-01 | 2016-09-20 |
NCT00994422 | Head Lice | Drug: Ivermectin cream|Drug: vehicle control | Topaz Pharmaceuticals Inc | Phase 2 | 2009-10-01 | 2012-04-04 |
NCT02045069 | Dengue Fever | Drug: 2 days Ivermectin|Drug: 3 days Ivermectin|Drug: Placebo | Mahidol University|Ministry of Health, Thailand | Phase 2|Phase 3 | 2014-02-01 | 2015-10-29 |
NCT02511353 | Malaria | Drug: ivermectin|Drug: placebo|Drug: dihydroartemisinin-piperaquine | Liverpool School of Tropical Medicine|Kenya Medical Research Institute|Centers for Disease Control and Prevention | Phase 2 | 2015-07-01 | 2016-09-06 |
NCT02407782 | Scabies | Drug: Ivermectin|Drug: Permethrin | University Hospital, Bordeaux | Phase 3 | 2016-01-01 | 2016-06-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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