| NCT02723864 | Neoplasms | Drug: Veliparib + VX-970 + Cisplatin | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2016-03-22 | 2017-03-21 |
| NCT02595931 | Advanced Malignant Solid Neoplasm|Metastatic Malignant Neoplasm|Metastatic Malignant Solid Neoplasm|Refractory Malignant Neoplasm|Unresectable Malignant Neoplasm|Unresectable Solid Neoplasm | Drug: ATR Kinase Inhibitor VX-970|Drug: Irinotecan Hydrochloride|Other: Laboratory Biomarker Analysis|Other: Pharmacological Study | National Cancer Institute (NCI) | Phase 1 | 2016-06-01 | 2017-03-13 |
| NCT02567422 | Head and Neck Squamous Cell Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Oropharyngeal Squamous Cell Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Oropharyngeal Squamous Cell Carcinoma | Drug: ATR Kinase Inhibitor VX-970|Drug: Cisplatin|Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Radiation: Radiation Therapy | National Cancer Institute (NCI) | Phase 1 | 2016-09-01 | 2017-03-13 |
| NCT02589522 | Lung Carcinoma Metastatic in the Brain|Stage IV Non-Small Cell Lung Cancer | Drug: ATR Kinase Inhibitor VX-970|Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Other: Quality-of-Life Assessment|Procedure: Therapeutic Conventional Surgery|Radiation: Whole-Brain Radiotherapy | National Cancer Institute (NCI) | Phase 1 | 2016-07-01 | 2017-03-23 |
| NCT02595892 | Ovarian Serous Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma | Drug: ATR Kinase Inhibitor VX-970|Drug: Gemcitabine Hydrochloride|Other: Laboratory Biomarker Analysis | National Cancer Institute (NCI) | Phase 2 | 2016-08-01 | 2017-02-15 |
| NCT02487095 | Carcinoma, Non-Small -Cell Lung|Ovarian Neoplasms|Small Cell Lung Carcinoma|Uterine Cervical Neoplasms|Carcinoma, Neuroendocrine | Drug: Topotecan|Drug: VX-970 | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2015-06-18 | 2017-03-23 |
| NCT02567409 | Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter|Stage IV Bladder Urothelial Carcinoma | Drug: ATR Kinase Inhibitor VX-970|Drug: Cisplatin|Drug: Gemcitabine Hydrochloride|Other: Laboratory Biomarker Analysis | National Cancer Institute (NCI) | Phase 2 | 2016-08-01 | 2017-03-22 |
| NCT02627443 | High Grade Ovarian Serous Adenocarcinoma|Ovarian Endometrioid Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer | Drug: ATR Kinase Inhibitor VX-970|Drug: Carboplatin|Drug: Gemcitabine Hydrochloride|Other: Laboratory Biomarker Analysis|Other: Pharmacological Study | National Cancer Institute (NCI) | Phase 1|Phase 2 | 2016-11-01 | 2017-03-23 |
| NCT02157792 | Advanced Solid Tumor | Drug: VX-970|Drug: Gemcitabine|Drug: Cisplatin|Drug: Etoposide|Drug: Carboplatin | Vertex Pharmaceuticals Incorporated | Phase 1 | 2012-12-01 | 2016-11-15 |
