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Clofazimine

氯法齐明,NSC-141046,Lamprene,NSC 141046,NSC141046,

Clofazimine是一种脂溶性亚氨基酚嗪类染料, 具有显著的抗炎效果, 与其它抗分支杆菌药物联用来AIDS和克罗恩病。

目录号
EY0437
EY0437
纯度
99.51%
99.51%
规格
100 mg
500 mg
原价
150
480
售价
150
480
库存
现货
现货
订购
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  • 生物活性

    Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Arbiser JL, et al. J Am Acad Dermatol, 1995, 32(2 Pt 1), 241-247.

    分子式
    C27H22Cl2N4    		 分子量
    473.4    		 CAS号
    2030-63-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mM    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    1 NCT02968212 Mycobacterium Avium Complex Drug: Clofazimine|Other: sugar pill Oregon Health and Science University|FDA Office of Orphan Products Development|National Heart, Lung, and Blood Institute (NHLBI)|National Jewish Health|The University of Texas Health Science Center at Tyler|National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2017-05-01 2017-03-21
    2 NCT01290744 Borderline Lepromatous Leprosy|Lepromatous Leprosy Drug: Clofazimine|Drug: Placebo Paul Saunderson|Leonard Wood Memorial Phase 4 2010-08-01 2015-06-03
    3 NCT00852345 Leprosy Drug: clofazamine Kaiser Permanente|Health Resources and Services Administration (HRSA) null 2015-04-02
    4 NCT00002058 Mycobacterium Avium-intracellulare Infection|HIV Infections Drug: Clofazimine University of California, San Francisco|NIH AIDS Clinical Trials Information Service null 2005-06-23
    5 NCT00002331 Mycobacterium Avium-intracellular Infection|HIV Infections Drug: Ethambutol hydrochloride|Drug: Clarithromycin|Drug: Clofazimine Abbott 1994-01-01 2015-01-15
    6 NCT01691534 Pulmonary Tuberculosis Drug: TMC207 (J)|Drug: PA-824 (PA)|Drug: pyrazinamide (Z)|Drug: clofazimine (C)|Drug: Rifafour Global Alliance for TB Drug Development Phase 2 2012-10-01 2016-10-19
    7 NCT00652067 Infection, Mycobacterium Avium-Intracellulare Yale University 2006-05-01 2008-04-02
    8 NCT00000641 Mycobacterium Avium-intracellulare Infection|HIV Infections Drug: Ciprofloxacin hydrochloride|Drug: Ethambutol hydrochloride|Drug: Amikacin sulfate|Drug: Azithromycin|Drug: Rifampin|Drug: Clofazimine National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 null 2012-03-29
    9 NCT00513552 Crohn's Disease Drug: Rifabutin, Clarithromycin, and Clofazimine Medstar Health Research Institute Phase 4 2007-01-01 2007-08-07
    10 NCT00669643 Leprosy Drug: PB 6 doses - Rifampicin and Dapsone|Drug: PB 6 doses - Rifampicin, Clofazimine and Dapsone|Drug: MB 12 doses - Rifampicin, Clofazimine and Dapsone|Drug: MB 6 doses - Rifampicin, Clofazimine and Dapsone University of Brasilia|Conselho Nacional de Desenvolvimento Cient铆fico e Tecnol贸gico|Ministry of Science and Technology, Brazil|Ministry of Health, Brazil|Funda莽茫o Alfredo da Matta, Manaus, Brazil|Instituto de Dermatologia Dona Libania, Fortaleza, Brazil Phase 4 2007-02-01 2016-07-15
    11 NCT00001047 Mycobacterium Avium-intracellulare Infection|HIV Infections Drug: Ethambutol hydrochloride|Drug: Clarithromycin|Drug: Clofazimine|Drug: Rifabutin National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 null 2012-03-30
    12 NCT03009396 Crohn Disease Drug: RHB-104 RedHill Biopharma Limited Phase 3 2017-03-18 2017-03-21
    13 NCT01885611 Hansen's Disease Other: Multi-Drug Therapy (Novartis 鈸?|Dietary Supplement: Virgin Coconut Oil Philippine Dermatological Society Phase 1|Phase 2 2013-06-01 2016-03-28
    14 NCT02589782 Tuberculosis, Multidrug-Resistant|Extensively Drug-Resistant Tuberculosis|Tuberculosis, Pulmonary Drug: Bedaquiline|Drug: Pretomanid|Drug: Moxifloxacin|Drug: Linezolid|Drug: Clofazimine|Drug: Locally accepted standard of care which is consistent with the WHO recommendations for the treatment of M/XDR-TB. Medecins Sans Frontieres, Netherlands|London School of Hygiene and Tropical Medicine|Global Alliance for TB Drug Development|University College, London|Drugs for Neglected Diseases|Swiss Tropical & Public Health Institute|eResearch Technology, Inc.|Ministry of Health, Republic of Uzbekistan|World Health Organization|Ministry of Health, Belarus|TB & HIV Investigative Network (THINK) Phase 2|Phase 3 2017-01-01 2017-01-16
    15 NCT02409290 MDR-TB Drug: Regimen A locally-used WHO-approved MDR-TB regimen|Drug: Moxifloxacin|Drug: Clofazimine|Drug: Ethambutol|Drug: Pyrazinamide|Drug: Isoniazid|Drug: Prothionamide|Drug: Kanamycin|Drug: Levofloxacin|Drug: Bedaquiline IUATLD, Inc|Medical Research Council Phase 3 2016-04-01 2016-05-31
    16 NCT00001058 Mycobacterium Avium-intracellulare Infection|HIV Infections Drug: Indinavir sulfate|Drug: Ritonavir|Drug: Ethambutol hydrochloride|Drug: Clarithromycin|Drug: Rifabutin National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 null 2012-04-02

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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