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Vecuronium Bromide

维库溴铵,维库罗宁,Vecuronium,ORG NC45,Norcuron

Vecuronium bromide (维库溴铵) 是非去极化阻断剂,可使肌肉松弛。

目录号
EY0436
EY0436
纯度
99.35%
99.35%
规格
50 mg
100 mg
原价
775
1100
售价
775
1100
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kindler CH, et al. Anesthesiology, 2000, 92(3), 821-832.

    分子式
    C34H57BrN2O4
    分子量
    637.73
    CAS号
    50700-72-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    120 mg/mL
    Water
    10 mg/mL
    Ethanol
    120 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00970762 Anesthesia Drug: Rocuronium 0.6 mg/kg intubating dose|Drug: Rocuronium 0.9 mg/kg intubating dose|Drug: Rocuronium 0.1 mg/kg maintenance dose|Drug: Rocuronium 0.15 mg/kg maintenance dose|Drug: Rocuronium 0.2 mg/kg maintenance|Drug: Vecuronium 0.1 mg/kg intubating dose|Drug: Vecuronium 0.025 mg/kg maintenance dose Merck Sharp & Dohme Corp. Phase 3 2003-02-01 2015-04-16
    NCT01379352 Liver Transplantation Samsung Medical Center 2011-06-01 2013-12-24
    NCT01690364 Motor Evoked Potential Monitoring|General Anesthesia|Neurosurgery|Brain Tumor|Spine Tumor|Cerebral Aneurysm Other: MEP monitoring with continuous infusion of vecuronium during general anesthesia|Other: MEP monitoring with continuous infusion of cisatracurium during general anesthesia Samsung Medical Center 2012-07-01 2013-12-24
    NCT00473694 Anesthesia, General Drug: sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2005-11-01 2016-05-13
    NCT00451217 Anesthesia, General Drug: Sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2005-11-01 2016-05-13
    NCT01690338 Perioperative/Postoperative Complications|PORC (Postoperative Residual Curarization) Drug: Vecuronium Bromide|Drug: Rocuronium|Drug: Cisatracurium Peking University First Hospital|Ruijin Hospital|RenJi Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital of Guangzhou Medical University|West China Hospital|Eastern Hepatobiliary Surgery Hospital|Wuhan Union Hospital, China|Zhujiang Hospital|Chinese PLA General Hospital|First Affiliated Hospital, Sun Yat-Sen University|The First Affiliated Hospital of Zhengzhou University|Tianjin Medical University General Hospital|Xiangya Hospital of Central South University|Central South University|Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|The First Teaching Hospital of Xinjiang Medical University|Peking Union Medical College Hospital|First Affiliated Hospital of Zhejiang University|China Medical University Hospital|Hebei Medical University Fourth Hospital|Tongji Hospital Phase 4 2012-10-01 2013-05-22
    NCT01388868 Brain Surgery With Motor Evoked Potential Monitoring|Spine Surgery With Motor Evoked Potential Monitoring Other: TOF count guided adjustment|Other: T1/ T0 guided adjustment|Other: T2/ T0 guided adjustment Samsung Medical Center 2011-06-01 2012-05-11
    NCT00552617 Anesthesia, General Drug: sugammadex (Org 25969)|Drug: Placebo Merck Sharp & Dohme Corp. Phase 2 2005-09-01 2016-05-05
    NCT02237443 Anesthesia Drug: Rocuronium|Drug: Vecuronium Bromide|Drug: Succinylcholine University of Washington Phase 4 2014-08-01 2015-04-07
    NCT00552929 Anesthesia, General Drug: Sugammadex|Drug: Placebo Merck Sharp & Dohme Corp. Phase 2 2005-10-01 2016-05-05
    NCT00591786 Anesthesia, General Drug: Sugammadex|Drug: Placebo Merck Sharp & Dohme Corp. Phase 2 2005-12-01 2016-05-02
    NCT01422304 Neuromuscular Blockade|Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee|Blood Coagulation|Antithrombotic Agents Drug: Sugammadex|Drug: neostigmine and glycopyrrolate or atropine|Drug: Placebo to neostigmine|Drug: Placebo to sugammadex Merck Sharp & Dohme Corp. Phase 3 2011-10-01 2015-09-03
    NCT00591409 Anesthesia, General Drug: sugammadex|Drug: Placebo Merck Sharp & Dohme Corp. Phase 2 2006-01-01 2016-05-02
    NCT02619578 C.Delivery; Surgery (Previous), Gynecological|Inappropriate Device Stimulation of Tissue|Delayed Emergence From Anesthesia Other: TEAS|Other: Con|Drug: propofol, remifentanil, vecuronium|Other: mechanical ventilation Guizhou Provincial People's Hospital 2013-11-01 2015-11-28
    NCT02510612 Diabetes Drug: Dexmedetomidine|Drug: placebo Shaanxi Provincial People's Hospital Phase 4 2015-08-01 2015-07-28
    NCT02797860 Pregnancy Drug: Rocuronium Hallym University Kangnam Sacred Heart Hospital 2016-06-01 2016-09-07
    NCT02134093 Postoperative Confusion Drug: Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium|Drug: Dexmedetomidine|Drug: Normal saline|Drug: Maintenance of anesthesia , propofol, remifentanil,vecuronium Tang-Du Hospital Phase 4 2014-07-01 2014-07-09
    NCT02123355 Cognitive Ability, General|Brain Injury Drug: Induction of anesthesia|Procedure: Intubation|Drug: Sevoflurane, remifentanil ,vecuronium|Drug: Dexmedetomidine|Drug: Placebo Shaanxi Provincial People's Hospital|Chinese Medical Association Phase 4 2014-08-01 2014-04-24
    NCT02593448 NIR Spectroscopy Procedure: NIRS during VOT|Procedure: General anaesthesia with propofol use|Procedure: General anaesthesia with sevoflurane use Medical University of Gdansk Phase 4 2012-03-01 2015-10-29
    NCT02562417 Neuromuscular Blockade Drug: Normal saline|Drug: IV dexamethasone Centre Hospitalier Universitaire Vaudois Phase 4 2016-06-01 2016-06-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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