Vecuronium bromide (维库溴铵) 是非去极化阻断剂,可使肌肉松弛。
Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kindler CH, et al. Anesthesiology, 2000, 92(3), 821-832.
分子式 C34H57BrN2O4 |
分子量 637.73 |
CAS号 50700-72-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 120 mg/mL |
Water 10 mg/mL |
Ethanol 120 mg/mL |
体内溶解度
NCT00970762 | Anesthesia | Drug: Rocuronium 0.6 mg/kg intubating dose|Drug: Rocuronium 0.9 mg/kg intubating dose|Drug: Rocuronium 0.1 mg/kg maintenance dose|Drug: Rocuronium 0.15 mg/kg maintenance dose|Drug: Rocuronium 0.2 mg/kg maintenance|Drug: Vecuronium 0.1 mg/kg intubating dose|Drug: Vecuronium 0.025 mg/kg maintenance dose | Merck Sharp & Dohme Corp. | Phase 3 | 2003-02-01 | 2015-04-16 |
NCT01379352 | Liver Transplantation | Samsung Medical Center | 2011-06-01 | 2013-12-24 | ||
NCT01690364 | Motor Evoked Potential Monitoring|General Anesthesia|Neurosurgery|Brain Tumor|Spine Tumor|Cerebral Aneurysm | Other: MEP monitoring with continuous infusion of vecuronium during general anesthesia|Other: MEP monitoring with continuous infusion of cisatracurium during general anesthesia | Samsung Medical Center | 2012-07-01 | 2013-12-24 | |
NCT00473694 | Anesthesia, General | Drug: sugammadex|Drug: neostigmine | Merck Sharp & Dohme Corp. | Phase 3 | 2005-11-01 | 2016-05-13 |
NCT00451217 | Anesthesia, General | Drug: Sugammadex|Drug: neostigmine | Merck Sharp & Dohme Corp. | Phase 3 | 2005-11-01 | 2016-05-13 |
NCT01690338 | Perioperative/Postoperative Complications|PORC (Postoperative Residual Curarization) | Drug: Vecuronium Bromide|Drug: Rocuronium|Drug: Cisatracurium | Peking University First Hospital|Ruijin Hospital|RenJi Hospital|Shanghai Zhongshan Hospital|The First Affiliated Hospital of Guangzhou Medical University|West China Hospital|Eastern Hepatobiliary Surgery Hospital|Wuhan Union Hospital, China|Zhujiang Hospital|Chinese PLA General Hospital|First Affiliated Hospital, Sun Yat-Sen University|The First Affiliated Hospital of Zhengzhou University|Tianjin Medical University General Hospital|Xiangya Hospital of Central South University|Central South University|Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|The First Teaching Hospital of Xinjiang Medical University|Peking Union Medical College Hospital|First Affiliated Hospital of Zhejiang University|China Medical University Hospital|Hebei Medical University Fourth Hospital|Tongji Hospital | Phase 4 | 2012-10-01 | 2013-05-22 |
NCT01388868 | Brain Surgery With Motor Evoked Potential Monitoring|Spine Surgery With Motor Evoked Potential Monitoring | Other: TOF count guided adjustment|Other: T1/ T0 guided adjustment|Other: T2/ T0 guided adjustment | Samsung Medical Center | 2011-06-01 | 2012-05-11 | |
NCT00552617 | Anesthesia, General | Drug: sugammadex (Org 25969)|Drug: Placebo | Merck Sharp & Dohme Corp. | Phase 2 | 2005-09-01 | 2016-05-05 |
NCT02237443 | Anesthesia | Drug: Rocuronium|Drug: Vecuronium Bromide|Drug: Succinylcholine | University of Washington | Phase 4 | 2014-08-01 | 2015-04-07 |
NCT00552929 | Anesthesia, General | Drug: Sugammadex|Drug: Placebo | Merck Sharp & Dohme Corp. | Phase 2 | 2005-10-01 | 2016-05-05 |
NCT00591786 | Anesthesia, General | Drug: Sugammadex|Drug: Placebo | Merck Sharp & Dohme Corp. | Phase 2 | 2005-12-01 | 2016-05-02 |
NCT01422304 | Neuromuscular Blockade|Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee|Blood Coagulation|Antithrombotic Agents | Drug: Sugammadex|Drug: neostigmine and glycopyrrolate or atropine|Drug: Placebo to neostigmine|Drug: Placebo to sugammadex | Merck Sharp & Dohme Corp. | Phase 3 | 2011-10-01 | 2015-09-03 |
NCT00591409 | Anesthesia, General | Drug: sugammadex|Drug: Placebo | Merck Sharp & Dohme Corp. | Phase 2 | 2006-01-01 | 2016-05-02 |
NCT02619578 | C.Delivery; Surgery (Previous), Gynecological|Inappropriate Device Stimulation of Tissue|Delayed Emergence From Anesthesia | Other: TEAS|Other: Con|Drug: propofol, remifentanil, vecuronium|Other: mechanical ventilation | Guizhou Provincial People's Hospital | 2013-11-01 | 2015-11-28 | |
NCT02510612 | Diabetes | Drug: Dexmedetomidine|Drug: placebo | Shaanxi Provincial People's Hospital | Phase 4 | 2015-08-01 | 2015-07-28 |
NCT02797860 | Pregnancy | Drug: Rocuronium | Hallym University Kangnam Sacred Heart Hospital | 2016-06-01 | 2016-09-07 | |
NCT02134093 | Postoperative Confusion | Drug: Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium|Drug: Dexmedetomidine|Drug: Normal saline|Drug: Maintenance of anesthesia , propofol, remifentanil,vecuronium | Tang-Du Hospital | Phase 4 | 2014-07-01 | 2014-07-09 |
NCT02123355 | Cognitive Ability, General|Brain Injury | Drug: Induction of anesthesia|Procedure: Intubation|Drug: Sevoflurane, remifentanil ,vecuronium|Drug: Dexmedetomidine|Drug: Placebo | Shaanxi Provincial People's Hospital|Chinese Medical Association | Phase 4 | 2014-08-01 | 2014-04-24 |
NCT02593448 | NIR Spectroscopy | Procedure: NIRS during VOT|Procedure: General anaesthesia with propofol use|Procedure: General anaesthesia with sevoflurane use | Medical University of Gdansk | Phase 4 | 2012-03-01 | 2015-10-29 |
NCT02562417 | Neuromuscular Blockade | Drug: Normal saline|Drug: IV dexamethasone | Centre Hospitalier Universitaire Vaudois | Phase 4 | 2016-06-01 | 2016-06-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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