Home > Topoisomerase & > Ofloxacin

Ofloxacin

氧氟沙星,氟嗪酸,DL 8280,DL-8280,DL8280

Ofloxacin是氟喹诺酮类抗生素,可抑制细菌DNA旋转酶。

目录号
EY0433
EY0433
EY0433
纯度
99.22%
99.22%
EY0433
规格
100 mg
500 mg
1 g
原价
112
340
430
售价
112
340
430
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ofloxacin is a synthetic broad-spectrum antimicrobial agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
    [2] Zhichao Liu et. Al. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 7(12), e1002310 (2011).

    分子式
    C18H20FN3O4
    分子量
    361.37
    CAS号
    82419-36-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    0.4 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00563433 Diabetic Foot Ulcers Drug: ofloxacin|Drug: MSI-78 MacroChem Corporation|Genaera Corporation Phase 3 1994-08-01 2007-11-21
    NCT00563394 Diabetic Foot Ulcers Drug: ofloxacin|Drug: MSI-78 MacroChem Corporation|Genaera Corporation Phase 3 1994-08-01 2007-11-21
    NCT01573910 Bacterial Conjunctivitis Drug: Moxifloxacin ophthalmic solution, 0.5%|Drug: Ofloxacin ophthalmic solution, 0.3% Alcon Research Phase 3 2012-05-01 2015-04-27
    NCT00176306 Obesity|Critical Illness Drug: Levofloxacin 750 mg IV University of Kentucky|Ortho-McNeil Pharmaceutical Phase 4 2005-01-01 2012-09-12
    NCT01371656 Acute Leukemias of Ambiguous Lineage|Bacterial Infection|Diarrhea|Fungal Infection|Musculoskeletal Complications|Neutropenia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies Drug: levofloxacin Children's Oncology Group|National Cancer Institute (NCI) Phase 3 2011-06-01 2017-02-13
    NCT02018081 Intensive Care Unit Syndrome|Community-acquired Pneumonia Drug: Levofloxacin University Hospital, Toulouse Phase 4 2012-03-01 2015-03-04
    NCT01055145 TB Drug: levofloxacin, moxifloxacin Seoul National University Hospital Phase 3 2010-03-01 2012-11-22
    NCT00645437 Renal Diseases Drug: Levofloxacin Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2004-10-01 2011-06-06
    NCT00002249 HIV Infections Drug: Levofloxacin R W Johnson Pharmaceutical Research Institute|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT00621387 Reactive Arthritis Drug: ofloxacin and roxithromycin|Drug: placebo Helsinki University 1993-11-01 2008-02-11
    NCT01761201 Latent Tuberculosis Infection|Infection in Solid Organ Transplant Recipients Drug: Levofloxacin|Drug: Isoniazid Fundaci贸n P煤blica Andaluza para la gesti贸n de la Investigaci贸n en Sevilla|Spanish Network for Research in Infectious Diseases Phase 3 2012-01-01 2014-08-05
    NCT00764582 Corneal Transplantation Drug: 1.5% levofloxacin ophthalmic solution|Drug: 0.5% moxifloxacin ophthalmic solution Santen Inc.|Vistakon Pharmaceuticals Phase 4 2008-09-01 2009-08-24
    NCT01168713 Community-Acquired Bacterial Pneumonia Drug: Levofloxacin|Drug: CEM-101 Cempra Inc Phase 2 2010-08-01 2017-03-01
    NCT01978938 Complicated Urinary Tract Infections (cUTI) Drug: Eravacycline|Drug: Levofloxacin Tetraphase Pharmaceuticals, Inc. Phase 3 2013-12-01 2016-05-24
    NCT01529476 Pneumonia Drug: Levofloxacin|Drug: Nemonoxacin TaiGen Biotechnology Co., Ltd.|Qualitix Clinical Research Co., Ltd.|Parexel|PPD Phase 3 2011-04-01 2013-06-17
    NCT01524302 Pneumonia, Bacterial|Community-acquired Drug: Ceftaroline|Drug: Levofloxacin Gary E. Stein, Pharm.D.|Forest Laboratories|Michigan State University Phase 4 2012-02-01 2016-03-14
    NCT02884713 GASTRITIS Drug: Levofloxacin|Drug: Doxycycline|Drug: Esomeprazole King Faisal Specialist Hospital & Research Center 2013-06-01 2016-08-25
    NCT01575899 Helicobacter Pylori Infection Drug: Levofloxacin-Amox/clav.|Drug: Clarithromycin-Amoxicillin Buddhist Tzu Chi General Hospital Phase 4 2007-12-01 2012-07-28
    NCT00035347 Community-Acquired Pneumonia (CAP) Drug: IV azithromycin|Drug: ceftriaxone|Drug: oral azithromycin|Drug: IV levofloxacin|Drug: oral levofloxacin Pfizer Phase 4 2001-01-01 2017-03-07
    NCT01537055 Eradication Rate for Helicobacter Drug: levofloxacin-based sequential therapy|Drug: levofloxacin-based triple therapy for 10 days National Taiwan University Hospital|E-DA Hospital Phase 4 2012-02-01 2015-01-30

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :