Home > Serine Protease & > Gabexate Mesylate

Gabexate Mesylate

甲磺酸加贝酯

Gabexate mesylate (甲磺酸加贝酯) 是非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。

目录号
EY0417
EY0417
EY0417
纯度
99.27%
99.27%
99.27%
规格
5 mg
10 mg
50 mg
原价
490
820
1500
售价
490
820
1500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Gabexate Mesylate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] S Aosasa et. Al,et al. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 15(2), 101-105 (2001)
    [2] Jiexiu Chen et. Al. Enhanced stability of oral insulin in targeted peptide ligand trimethyl chitosan nanoparticles against trypsin. Journal of Microencapsulation, 32(7), 632-641 (2015).
    [3] Shannon B Z Stephens et. Al. Neonatal amygdala lesions advance pubertal timing in female rhesus macaques. Psychoneuroendocrinology, 51, 307-317 (2015).

    分子式
    C17H27N3O7S
    分子量
    417.48
    CAS号
    56974-61-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    82 mg/mL
    Water
    10 mg/mL
    Ethanol
    82 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02710266 Liver Disease Drug: Preoperative Gabexate Mesilate group|Drug: Intraoperative Gabexate Mesilate group|Drug: hepatectomy with dextrose water Yonsei University Phase 3 2016-02-01 2016-11-14
    NCT01910714 HIV/AIDS Behavioral: Focus On Youth|Behavioral: Health Education Control Condition Johns Hopkins Bloomberg School of Public Health 2010-09-01 2015-04-15
    NCT01528761 Physical Activity Behavioral: Prosocial Behavior Physical Activity (PBPA)|Other: Healthy Aging (HA) Wake Forest University Health Sciences 2012-02-01 2016-01-21
    NCT00887055 Heart Failure Device: CRT device Guidant Corporation Phase 4 null 2015-06-26
    NCT00747019 Health-Related Quality of Life|Physical Activity|Physical Function Behavioral: Prosocial Behavior Physical Activity (PBPA)|Behavioral: Physical Exercise (PE) National Institute on Aging (NIA) 2008-12-01 2009-06-30
    NCT01716130 Patient Response to Fluzone ID Vaccine Touro University, California|Sanofi 2011-10-01 2012-10-24
    NCT03075813 Infection Control|Surgical Site Infection Other: Intervention Cluster Duke University|Agency for Healthcare Research and Quality (AHRQ) 2017-03-01 2017-03-16
    NCT02501577 Intubation; Difficult Device: SAD 1|Device: SAD 2 University of Regensburg 2015-03-01 2015-07-16
    NCT02782156 Substance Withdrawal Syndrome Other: Process evaluation University Hospital, Basel, Switzerland 2014-11-01 2016-07-11
    NCT02693093 Chronic Pancreatitis Drug: NI-03|Drug: Placebo Stason Pharmaceuticals, Inc. Phase 1|Phase 2 2015-12-01 2016-07-22
    NCT01002911 Arrythmias Drug: Cefazolin, Bacitracin, Cefalexin|Drug: Cefazolin Population Health Research Institute Phase 3 2009-12-01 2013-05-14
    NCT00835445 Nasal Polyps|Asthma Laval University 2007-07-01 2011-01-06
    NCT01380496 To Determine Bioequivalence Under Fed Conditions. Drug: doxycycline monohydrate|Drug: doxycycline monohydrate|Drug: doxycycline monohydrate Par Pharmaceutical, Inc.|Anapharm Phase 1 1999-11-01 2011-06-22
    NCT01380483 To Determine Bioequivalence Under Fasting Conditions Drug: doxycycline monohydrate|Drug: doxycycline monohydrate Par Pharmaceutical, Inc.|Anapharm Phase 1 2000-01-01 2011-06-22
    NCT01282814 Healthy Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR Teva Pharmaceuticals USA Phase 1 2003-02-01 2011-02-11
    NCT01282801 Healthy Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR Teva Pharmaceuticals USA Phase 1 2002-09-01 2011-02-11
    NCT01260896 Healthy Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR Teva Pharmaceuticals USA Phase 1 2002-09-01 2011-01-24
    NCT01190761 Healthy Drug: Galantamine 4 mg Tablet, single dose|Drug: Reminyl 4 mg Tablet, single dose Actavis Inc. Phase 1 2004-12-01 2010-08-27
    NCT01190748 Healthy Drug: Galantamine 4 mg Tablet, single dose|Drug: Reminyl 4 mg Tablet, single dose Actavis Inc. Phase 1 2004-11-01 2010-08-27
    NCT01149460 Healthy Drug: Valacyclovir|Drug: Valacyclovir Teva Pharmaceuticals USA Phase 1 2004-09-01 2010-08-18
    NCT01124175 Healthy Drug: Losartan|Drug: Cozaar庐 Teva Pharmaceuticals USA Phase 1 2003-10-01 2010-11-22
    NCT01053689 Healthy Drug: Glimepiride tablets 1 mg Dr. Reddy's Laboratories Limited Phase 1 2003-12-01 2010-01-19
    NCT01052909 Healthy Drug: Glimepiride Dr. Reddy's Laboratories Limited Phase 1 2003-12-01 2010-01-19
    NCT01044706 Healthy Drug: Bicalutamide Kremers Urban Development Company|Watson Pharmaceuticals Phase 1 2005-05-01 2010-02-28
    NCT00973050 Healthy Drug: Bicalutamide|Drug: Casodex庐 Teva Pharmaceuticals USA Phase 1 2003-09-01 2009-09-08

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :