Zoledronic Acid 是一种有效的含氮双膦酸盐,抑制人胎儿成骨细胞(hFOB)增殖,IC50为40 μM。
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Jagdev SP, et al. Br J Cancer, 2001, 84(8), 1126-1134.
[2] Anja Verhulst,et al. PLoS One. 2015; 10(3): e0121861. Published online 2015 Mar 10. doi: 10.1371/journal.pone.0121861.
分子式 C5H10N2O7P2 |
分子量 272.09 |
CAS号 118072-93-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 0.004 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT00892242 | Adenocarcinoma | Drug: Zoledronic acid | Washington University School of Medicine | Phase 1 | 2009-12-01 | 2014-09-19 |
NCT01204203 | Mesothelioma | Drug: Zometa | University of Alabama at Birmingham|Novartis Pharmaceuticals | Phase 2 | 2009-06-01 | 2016-05-20 |
NCT00512993 | Breast Cancer | Drug: Zoledronic acid | German Breast Group|Austrian Breast & Colorectal Cancer Study Group|Novartis Pharmaceuticals | Phase 3 | 2004-12-01 | 2015-03-04 |
NCT00982124 | Osteogenesis Imperfecta | Drug: Zoledronic Acid | Shriners Hospitals for Children|Novartis | Phase 3 | 2007-10-01 | 2016-04-18 |
NCT00566618 | Breast Cancer|Bone Metastases | Drug: Dasatinib|Drug: Zoledronic Acid | M.D. Anderson Cancer Center|Bristol-Myers Squibb | Phase 1|Phase 2 | 2007-11-01 | 2016-12-08 |
NCT01788176 | Complex Regional Pain Syndromes | Drug: Zoledronic acid|Drug: Placebo | University of Sao Paulo General Hospital|Novartis | Phase 2 | 2013-12-01 | 2013-02-08 |
NCT02042872 | Disuse Osteoporosis | Drug: Zoledronic acid | James J. Peters Veterans Affairs Medical Center|Kessler Institute for Rehabilitation | Phase 4 | 2006-05-01 | 2015-05-05 |
NCT00237146 | Prostate Cancer | Drug: Zoledronic acid | Novartis Pharmaceuticals|Novartis | Phase 4 | 2003-11-01 | 2017-02-21 |
NCT01197300 | Osteoporosis | Drug: zoledronic acid | Novartis Pharmaceuticals|Novartis | Phase 3 | 2010-10-01 | 2016-06-10 |
NCT00889590 | Giant Cell Tumor of Bone|Osteoclastoma | Drug: Zoledronic acid | Leiden University Medical Center | Phase 2 | 2008-12-01 | 2016-01-25 |
NCT00712985 | Breast Cancer | Drug: Zometa | Milton S. Hershey Medical Center|Novartis | Phase 3 | 2005-09-01 | 2014-03-24 |
NCT02123264 | Arthritis, Rheumatoid | Drug: Zoledronic acid | Carmen G贸mez-Vaquero|Hospital Universitari de Bellvitge | Phase 3 | 2014-05-01 | 2016-02-21 |
NCT00145327 | Osteoporosis | Drug: Zoledronic Acid|Drug: Placebo | Novartis | Phase 3 | 2005-05-01 | 2011-06-24 |
NCT00172042 | Non-Small-Cell Lung Cancer | Drug: Zoledronic acid 4 mg | Novartis Pharmaceuticals|Novartis | Phase 3 | 2005-03-01 | 2015-04-13 |
NCT01642901 | Spinal Cord Injury | Drug: Zoledronic acid|Drug: normal saline 0.9% | Thomas Jefferson University|Department of Health and Human Services | Phase 3 | 2012-05-01 | 2017-01-12 |
NCT00361595 | Osteoporosis | Drug: zoledronic acid | The Cleveland Clinic|Novartis Pharmaceuticals | 2006-08-01 | 2010-12-14 | |
NCT00376740 | Breast Cancer | Drug: zoledronic acid | Soroka University Medical Center|Tel-Aviv Sourasky Medical Center | Phase 3 | 2005-09-01 | 2011-08-22 |
NCT01004510 | Malignant Pleural Effusion|Non Small Cell Lung Cancer | Drug: zoledronic acid | Peter Bushunow MD|Novartis Pharmaceuticals|Rochester General Hospital | Phase 2 | 2009-11-01 | 2012-11-05 |
NCT00216151 | Multiple Myeloma | Drug: Zoledronic Acid | Hoosier Cancer Research Network|Novartis Pharmaceuticals|Walther Cancer Institute | Phase 2 | 2005-06-01 | 2011-04-28 |
NCT01016093 | Beta-Thalassemia|Bone Marrow Transplantation | Drug: Zoledronic acid|Drug: Placebo | Tehran University of Medical Sciences|Novartis | Phase 2|Phase 3 | 2009-11-01 | 2011-07-25 |
NCT02480634 | Non-small Cell Lung Cancer|Bone Metastasis | Drug: Zoledronic acid|Radiation: Radiotherapy | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Phase 4 | 2016-06-01 | 2016-06-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们