TCID是一种DUB抑制剂,抑制ubiquitin C-terminal hydrolase L3(泛素C-末端水解酶L3),IC50为0.6 μM,作用于L1选择性高125倍。
TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Liu Y, et al. Chem Biol, 2003, 10(9), 837-846.
分子式 C9H2Cl4O2 |
分子量 283.92 |
CAS号 30675-13-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 25 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
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注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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