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TCID

TCID是一种DUB抑制剂,抑制ubiquitin C-terminal hydrolase L3(泛素C-末端水解酶L3),IC50为0.6 μM,作用于L1选择性高125倍。

目录号
EY0406
EY0406
EY0406
纯度
99.36%
99.36%
99.36%
规格
1 mg
5 mg
10 mg
原价
220
550
915
售价
220
550
915
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Liu Y, et al. Chem Biol, 2003, 10(9), 837-846.

    分子式
    C9H2Cl4O2
    分子量
    283.92
    CAS号
    30675-13-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    25 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00914732 Smallpox Biological: MVA Smallpox Vaccine|Biological: MVA Smallpox Vaccine|Biological: MVA Smallpox Vaccine National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2010-02-01 2014-12-04
    NCT00879762 Variola Major (Smallpox) Biological: IMVAMUNE庐 High Dose|Drug: Placebo|Biological: IMVAMUNE庐 Standard Dose National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2009-05-01 2012-12-06
    NCT01466738 Healthy Biological: HRV-16 (100 TCID50)|Biological: HRV-16 (1000 TCID50) Centocor Ortho Biotech Services, L.L.C. Phase 1 2011-09-01 2012-02-20
    NCT00565929 Variola Major (Smallpox) Drug: Placebo|Biological: MVA-BN National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 2008-09-01 2013-08-01
    NCT00508651 Healthy Biological: MEDI-560|Biological: Placebo MedImmune LLC Phase 1|Phase 2 2007-10-01 2011-11-28
    NCT02824965 Non-Small Cell Lung Cancer Drug: Pembrolizumab|Biological: CVA21 Olivia Newton-John Cancer Research Institute|Merck Sharp & Dohme Corp.|Viralytics Phase 1 2016-07-01 2016-07-10
    NCT00386633 HIV Infections Biological: MVA-mBN32|Biological: MVA-mBN32 Bavarian Nordic Phase 1 2006-10-01 2015-01-26
    NCT02419391 Respiratory Syncytial Virus Infections Biological: MVA BN RSV|Other: Placebo Bavarian Nordic Phase 1 2015-08-01 2016-08-09
    NCT00390078 HIV Infections Biological: MVA-mBN32|Biological: IMVAMUNE Bavarian Nordic|National Institutes of Health (NIH) Phase 1|Phase 2 2007-01-01 2009-07-09
    NCT02977715 Monkeypox Virus Infection Biological: IMVAMUNE庐 Centers for Disease Control and Prevention|Ministry of Public Health, Democratic Republic of the Congo|Kinshasa School of Public Health|Bavarian Nordic Phase 3 2017-02-23 2017-02-27
    NCT00651157 Recurrent Melanoma|Stage IV Melanoma Biological: wild-type reovirus National Cancer Institute (NCI) Phase 2 2008-04-01 2014-03-21
    NCT01491893 GBM|Glioblastoma|Glioma|Malignant Glioma Biological: PVSRIPO Darell D. Bigner, MD, PhD|National Cancer Institute (NCI)|Brain Tumor Research Charity Grant|Duke University Phase 1 2012-01-01 2017-03-21
    NCT01866306 Asthma Biological: RV16UB|Drug: LABA Merck Sharp & Dohme Corp.|U-BIOPRED Consortium Phase 1 2013-10-01 2017-01-23
    NCT00493285 Respiratory Viral Infections|Respiratory Syncytial Virus Infections|Parainfluenza Virus 3, Human Biological: MEDI-534|Biological: MEDI-534|Biological: MEDI-534 MedImmune LLC Phase 1 2007-07-01 2012-07-13
    NCT01078701 Influenza, Human Biological: GHB11L1|Biological: Placebo AVIR Green Hills Biotechnology AG Phase 2 2009-12-01 2011-01-04
    NCT01922284 HIV Biological: DNA|Biological: MVA-C|Biological: CN54rgp140|Biological: GLA-AF Imperial College London|Medical Research Council|Wellcome Trust Phase 1 2013-06-01 2016-09-26
    NCT01827371 Smallpox Biological: MVA Smallpox Vaccine National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2013-06-01 2016-07-28
    NCT03028441 Chikungunya Virus Infection Biological: Chikungunya vaccine|Other: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2017-03-02
    NCT00724997 Seasonal Human Influenza Biological: GHB01L1 AVIR Green Hills Biotechnology AG Phase 1 2007-03-01 2009-12-07
    NCT02755948 Respiratory Syncytial Virus Infections|Influenza, Human Biological: RSV A Memphis 37|Biological: Influenza A/California/04/2009 Imperial College London|Medical Research Council|Wellcome Trust|National Institute for Health Research, United Kingdom 2012-04-01 2016-04-26
    NCT00316524 Smallpox Biological: MVA-BN庐 (IMVAMUNE)|Biological: IMVAMUNE|Biological: IMVAMUNE|Biological: IMVAMUNE Bavarian Nordic|National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2006-05-01 2015-06-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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