Estradiol Benzoate是一种雌激素类似物,可以与人源,鼠源以及鸡的ERα结合,IC50范围22-28 nM。
Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Matthews J, et al. J Steroid Biochem Mol Biol, 2000, 74(4), 223-234.
分子式 C25H28O3 |
分子量 376.49 |
CAS号 50-50-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 75 mg/mL |
Water Insoluble |
Ethanol 2 mg/mL |
体内溶解度
NCT00984399 | Atrophic Vaginitis|Breast Cancer | Drug: Vagifem庐 (vaginal 17尾-estradiol) questionnaire & menopause symptom checklist | Memorial Sloan Kettering Cancer Center | 2009-09-01 | 2016-05-31 | |
NCT00698035 | Sexual Dysfunction, Physiological | Drug: Testosterone Cream|Drug: Estring | University of California, San Francisco | Phase 2 | 2007-03-01 | 2014-05-27 |
NCT01753102 | Vulvar Atrophy|Vaginal Atrophy | Drug: Estradiol | Sun Pharmaceutical Industries Limited | Phase 3 | 2012-11-01 | 2015-05-19 |
NCT00744328 | Postpartum Depression | Drug: Transdermal Estradiol|Drug: Sertraline|Other: Placebo | Northwestern University | Phase 4 | 2008-08-01 | 2014-10-20 |
NCT01923298 | Estrogen Levels Among Breast Cancer Patients | Drug: Estradiol | University of Arizona | Phase 2 | 2013-08-09 | 2017-02-03 |
NCT00741858 | Chiari Malformation | Procedure: Duragen duraplasty|Procedure: Duraguard duraplasty | University of Illinois at Chicago | Phase 3 | 2003-04-01 | 2015-07-08 |
NCT01218386 | Infertility | Drug: Estradiol valerate | Universitair Ziekenhuis Brussel | Phase 4 | 2010-05-01 | 2012-03-27 |
NCT02626208 | Suppression of Ovulation | Device: Nestorone庐/Estradiol Contraceptive Vaginal Ring | Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 2 | 2016-01-01 | 2016-11-14 |
NCT00870220 | Turner's Syndrome | Drug: Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch | University of Chicago|Novo Nordisk A/S|University of Michigan|Johns Hopkins University|Massachusetts General Hospital|University of Oklahoma|University of South Florida|Thomas Jefferson University | Phase 1 | 2009-04-01 | 2014-03-10 |
NCT01109979 | Cardiovascular Diseases | Drug: Estradiol+MPA|Drug: Estradiol+Drospirenone | Brigham and Women's Hospital|Bayer | Phase 4 | 2009-12-01 | 2016-06-10 |
NCT00167648 | Cancer|Prostate Neoplasms | Drug: Leuprolide or goserelin|Drug: Transdermal estradiol | University of Washington|Pacific Northwest SPORE (Specialized Projects in Oncology Research Excellence) | Phase 2 | 2005-03-01 | 2009-01-15 |
NCT00789802 | Contraception|Bleeding | Drug: transdermal estradiol|Drug: naproxen|Drug: oral placebo | Washington University School of Medicine|American College of Obstetricians and Gynecologists | 2008-11-01 | 2014-12-08 | |
NCT00563576 | Metrorrhagia | Drug: Femring庐|Drug: DepoProvera 庐 | Columbia University | 2007-09-01 | 2012-12-11 | |
NCT02792153 | Anorexia Nervosa | Drug: Estradiol | Johns Hopkins University | Phase 1 | 2016-12-01 | 2016-12-12 |
NCT01779947 | Atrophic Vaginitis Due to Menopause | Drug: Estradiol Vaginal Tablets 10 mcg|Drug: placebo | Amneal Pharmaceuticals, LLC | Phase 3 | 2012-03-01 | 2014-06-25 |
NCT02238808 | Estrogen Receptor Positive Breast Cancer | Drug: Estradiol | AHS Cancer Control Alberta | Phase 2 | 2015-08-01 | 2017-01-04 |
NCT02485821 | Failed Induction of Labor | Drug: Estradiol|Drug: Placebo|Drug: Misoprostol | Ain Shams University | Phase 2|Phase 3 | 2015-06-01 | 2016-02-14 |
NCT00775242 | Menopause | Drug: Estradiol and Progesterone|Drug: Estradiol and Progesterone | Centro A.F. de Estudios Tecnologicos, S.A. | Phase 2|Phase 3 | 2007-04-01 | 2009-08-21 |
NCT01293747 | Menopause | Drug: Estradiol + Progesterone|Drug: Estradiol + Progesterone | Productos Cient铆ficos S. A. de C. V. | Phase 1 | 2011-02-01 | 2011-10-12 |
NCT01553773 | Atrophy | Drug: isoflavone|Drug: Estradiol | Federal University of S茫o Paulo|Coordena莽茫o de Aperfei莽oamento de Pessoal de N铆vel Superior. | Phase 2 | 2004-07-01 | 2012-03-13 |
NCT01597986 | Pharmacokinetics of Isavuconazole|Pharmacokinetics of Ethinyl Estradiol and Norethindrone|Healthy Volunteers | Drug: isavuconazole|Drug: Oral Contraceptive (ethinyl estradiol / norethindrone) | Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc | Phase 1 | 2012-04-01 | 2012-07-12 |
NCT02255175 | Perimenopausal Depression | Drug: Estradiol|Drug: Progesterone | University of North Carolina, Chapel Hill|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute of Mental Health (NIMH) | Phase 4 | 2015-10-01 | 2016-05-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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