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Estradiol Benzoate

雌二醇苯甲酸酯,苯甲酸雌二醇

Estradiol Benzoate是一种雌激素类似物,可以与人源,鼠源以及鸡的ERα结合,IC50范围22-28 nM。

目录号
EY0401
EY0401
纯度
99.29%
99.29%
规格
100 mg
500 mg
原价
150
385
售价
150
385
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Matthews J, et al. J Steroid Biochem Mol Biol, 2000, 74(4), 223-234.

    分子式
    C25H28O3
    分子量
    376.49
    CAS号
    50-50-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    75 mg/mL
    Water
    Insoluble
    Ethanol
    2 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00984399 Atrophic Vaginitis|Breast Cancer Drug: Vagifem庐 (vaginal 17尾-estradiol) questionnaire & menopause symptom checklist Memorial Sloan Kettering Cancer Center 2009-09-01 2016-05-31
    NCT00698035 Sexual Dysfunction, Physiological Drug: Testosterone Cream|Drug: Estring University of California, San Francisco Phase 2 2007-03-01 2014-05-27
    NCT01753102 Vulvar Atrophy|Vaginal Atrophy Drug: Estradiol Sun Pharmaceutical Industries Limited Phase 3 2012-11-01 2015-05-19
    NCT00744328 Postpartum Depression Drug: Transdermal Estradiol|Drug: Sertraline|Other: Placebo Northwestern University Phase 4 2008-08-01 2014-10-20
    NCT01923298 Estrogen Levels Among Breast Cancer Patients Drug: Estradiol University of Arizona Phase 2 2013-08-09 2017-02-03
    NCT00741858 Chiari Malformation Procedure: Duragen duraplasty|Procedure: Duraguard duraplasty University of Illinois at Chicago Phase 3 2003-04-01 2015-07-08
    NCT01218386 Infertility Drug: Estradiol valerate Universitair Ziekenhuis Brussel Phase 4 2010-05-01 2012-03-27
    NCT02626208 Suppression of Ovulation Device: Nestorone庐/Estradiol Contraceptive Vaginal Ring Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 2016-01-01 2016-11-14
    NCT00870220 Turner's Syndrome Drug: Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch University of Chicago|Novo Nordisk A/S|University of Michigan|Johns Hopkins University|Massachusetts General Hospital|University of Oklahoma|University of South Florida|Thomas Jefferson University Phase 1 2009-04-01 2014-03-10
    NCT01109979 Cardiovascular Diseases Drug: Estradiol+MPA|Drug: Estradiol+Drospirenone Brigham and Women's Hospital|Bayer Phase 4 2009-12-01 2016-06-10
    NCT00167648 Cancer|Prostate Neoplasms Drug: Leuprolide or goserelin|Drug: Transdermal estradiol University of Washington|Pacific Northwest SPORE (Specialized Projects in Oncology Research Excellence) Phase 2 2005-03-01 2009-01-15
    NCT00789802 Contraception|Bleeding Drug: transdermal estradiol|Drug: naproxen|Drug: oral placebo Washington University School of Medicine|American College of Obstetricians and Gynecologists 2008-11-01 2014-12-08
    NCT00563576 Metrorrhagia Drug: Femring庐|Drug: DepoProvera 庐 Columbia University 2007-09-01 2012-12-11
    NCT02792153 Anorexia Nervosa Drug: Estradiol Johns Hopkins University Phase 1 2016-12-01 2016-12-12
    NCT01779947 Atrophic Vaginitis Due to Menopause Drug: Estradiol Vaginal Tablets 10 mcg|Drug: placebo Amneal Pharmaceuticals, LLC Phase 3 2012-03-01 2014-06-25
    NCT02238808 Estrogen Receptor Positive Breast Cancer Drug: Estradiol AHS Cancer Control Alberta Phase 2 2015-08-01 2017-01-04
    NCT02485821 Failed Induction of Labor Drug: Estradiol|Drug: Placebo|Drug: Misoprostol Ain Shams University Phase 2|Phase 3 2015-06-01 2016-02-14
    NCT00775242 Menopause Drug: Estradiol and Progesterone|Drug: Estradiol and Progesterone Centro A.F. de Estudios Tecnologicos, S.A. Phase 2|Phase 3 2007-04-01 2009-08-21
    NCT01293747 Menopause Drug: Estradiol + Progesterone|Drug: Estradiol + Progesterone Productos Cient铆ficos S. A. de C. V. Phase 1 2011-02-01 2011-10-12
    NCT01553773 Atrophy Drug: isoflavone|Drug: Estradiol Federal University of S茫o Paulo|Coordena莽茫o de Aperfei莽oamento de Pessoal de N铆vel Superior. Phase 2 2004-07-01 2012-03-13
    NCT01597986 Pharmacokinetics of Isavuconazole|Pharmacokinetics of Ethinyl Estradiol and Norethindrone|Healthy Volunteers Drug: isavuconazole|Drug: Oral Contraceptive (ethinyl estradiol / norethindrone) Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc Phase 1 2012-04-01 2012-07-12
    NCT02255175 Perimenopausal Depression Drug: Estradiol|Drug: Progesterone University of North Carolina, Chapel Hill|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute of Mental Health (NIMH) Phase 4 2015-10-01 2016-05-04

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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