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Tanshinone IIA

丹参酮IIA,Tanshinone B

Tanshinone IIA是丹参和Salviae miltiorrhizae Radix中最丰富的二萜醌类，用于治疗心血管疾病和炎症性疾病。

目录号
EY0399
EY0399
EY0399
EY0399
纯度
99.29%
99.29%
99.29%
99.29%
规格
1 mg
5 mg
10 mg
50 mg
原价
160
350
560
1900
售价
160
350
560
1900
库存
现货
现货
现货
现货
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  • 生物活性

    Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Fu J, et al. Eur J Pharmacol, 2007, 568(1-3), 213-221.
    [2] Hong, HJ. et al. 2012. Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells. Clin. Exp. Pharmacol. Physiol.. 39: 63-8.
    [3] Gao, J. et al. 2008. Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis. Transl Res. 151: 79-87.
    [4] Jang, SI. et al. 2006. Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways. Eur. J. Pharmacol.. 542: 1-7.

    分子式
    C19H18O3    		 分子量
    294.34    		 CAS号
    568-72-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01637675 Pulmonary Hypertension|Pulmonary Arterial Hypertension|Cardiovascular Diseases|Lung Diseases|Tanshinone IIA Sulfonate Drug: 20 mg sildenafil citrate by mouth|Drug: sodium tanshinone IIA sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth The First Affiliated Hospital of Guangzhou Medical University|Jiangsu Carefree Pharmaceutical Co., Ltd.|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|Guangdong General Hospital|Sir Run Run Shaw Hospital|The First Affiliated Hospital of Zhengzhou University|Dongguan People's Hospital|Second Affiliated Hospital of Xi'an Jiaotong University|Beijing Chao Yang Hospital|Beijing Anzhen Hospital|Qingdao University Phase 2|Phase 3 2013-05-01 2014-03-28
    NCT02524964 Left Ventricular Remodeling|Acute Myocardial Infarction Drug: sodium tanshinone IIA sulfonate|Other: control Guangdong Provincial Hospital of Traditional Chinese Medicine Phase 4 2015-12-01 2016-08-31
    NCT01452477 Polycystic Ovary Syndrome Drug: tanshinone|Drug: tanshinone placebo Heilongjiang University of Chinese Medicine 2011-10-01 2013-09-03
    NCT02200978 Childhood Acute Promyelocytic Leukemia Drug: ATO|Drug: RIF|Drug: ATRA|Drug: mitoxantrone|Drug: Ara-C|Drug: MTX|Drug: 6MP|Other: intrathecal injection South China Children's Leukemia Group Phase 4 2011-09-01 2016-04-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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