Ritonavir是一种HIV蛋白酶抑制剂,用于治疗HIV感染和AIDS。
Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Eagling VA, et al. Br J Clin Pharmacol, 1997, 44(2), 190-194.
分子式 C37H48N6O5S2 |
分子量 720.94 |
CAS号 155213-67-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT01074931 | HIV-1 Infections | Drug: Lopinavir/ritonavir (Kaletra) | Abbott | 2008-04-01 | 2011-07-07 | |
NCT02503462 | AIDS-related Dementia Complex | Drug: Darunavir|Drug: ritonavir|Drug: cobicistat | University Hospital, Basel, Switzerland | Phase 4 | 2015-07-01 | 2017-02-01 |
NCT00985543 | Acquired Immunodeficiency Syndrome | Drug: lopinavir/ritonavir | Kirby Institute | Phase 1 | 2009-10-01 | 2011-03-02 |
NCT01810887 | Healthy | Drug: Darunavir|Drug: Ritonavir | Janssen Pharmaceutical K.K. | Phase 4 | 2008-05-01 | 2013-04-09 |
NCT00885495 | HIV Infections | Drug: darunavir, ritonavir, rosuvastatin|Drug: rosuvastatin, darunavir, ritonavir | University of Cincinnati | Phase 1|Phase 2 | 2009-01-01 | 2009-04-21 |
NCT01047995 | HIV Infections | Drug: Raltegravir plus Darunavir/ritonavir|Drug: Raltegravir plus Darunavir/ritonavir | St Stephens Aids Trust | Phase 1 | 2009-06-01 | 2010-01-12 |
NCT00621166 | HIV Infections | Drug: generic lopinavir/ritonavir | The HIV Netherlands Australia Thailand Research Collaboration | Phase 2 | 2008-06-01 | 2012-04-03 |
NCT00477126 | Healthy | Drug: GPO ritonavir versus Norvir | The HIV Netherlands Australia Thailand Research Collaboration|The Government Pharmaceutical Organization | Phase 1 | 2007-01-01 | 2012-04-03 |
NCT01172535 | HIV | Drug: Lopinavir/ritonavir | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2|Phase 3 | 2010-11-01 | 2015-11-16 |
NCT02034838 | HIV Infection | Drug: atazanavir 300mg boosted with ritonavir 50 mg | Ottawa Hospital Research Institute|Bristol-Myers Squibb | Phase 1 | 2014-01-01 | 2015-09-21 |
NCT01237444 | HIV Infection | Drug: lopinavir/ritonavir plus one nucleoside|Drug: lopinavir /ritonavir plus two nucleosides | Pedro Cahn|Abbott|The Huesped Foundation | Phase 3 | 2010-12-01 | 2012-06-08 |
NCT01700790 | AIDS|Tuberculosis | Drug: Lopinavir/ritonavir and ritonavir | University of Miami|Oswaldo Cruz Foundation | Phase 4 | 2016-01-01 | 2016-12-06 |
NCT01581853 | HIV | Drug: Lopinavir/ritonavir 800 mg / 200mg | Daniel Podzamczer|Hospital Universitari de Bellvitge | Phase 4 | 2012-05-01 | 2016-10-05 |
NCT02348177 | Acquired Immunodeficiency Syndrome|Tuberculosis | Drug: lopinavir with ritonavir in 1:1 ratio|Drug: Lopinavir/ritonavir 4:1 | Drugs for Neglected Diseases|University of Cape Town|Medecins Sans Frontieres, Netherlands|French Development Agency|UBS Optimus Foundation | Phase 4 | 2013-01-01 | 2015-01-22 |
NCT01002898 | HIV | Drug: lopinavir/ritonavir soft gel capsule | Bamrasnaradura Infectious Diseases Institute | Phase 3 | 2007-04-01 | 2011-11-10 |
NCT01009437 | Breast Cancer | Drug: ritonavir|Procedure: therapeutic conventional surgery | Masonic Cancer Center, University of Minnesota|Susan G. Komen Breast Cancer Foundation | Phase 1|Phase 2 | 2010-05-01 | 2016-01-21 |
NCT01258439 | HIV|Cardiovascular Disease | Drug: raltegravir plus truvada|Drug: Darunavir, ritonavir, tenofovir/emtricitabine (Truvada) | St Vincent's Hospital, Sydney|Merck Sharp & Dohme Corp. | Phase 4 | 2010-11-01 | 2015-01-08 |
NCT01695954 | Hyperlipidemia|HIV | Drug: Pitavastatin|Drug: Darunavir|Drug: Ritonavir|Drug: Efavirenz | New York University School of Medicine|Bellevue/NYU AIDS Clinical Trials Unit|Kowa Pharmaceuticals America, Inc.|University at Buffalo | Phase 1 | 2012-05-01 | 2012-09-27 |
NCT00855413 | Acute HIV Infection|HIV Infections | Drug: Darunavir/Ritonavir and Etravirine | University of North Carolina, Chapel Hill|Janssen Pharmaceuticals | Phase 4 | 2009-03-01 | 2014-10-14 |
NCT02527707 | Chronic Delta Hepatitis | Drug: lonafarnib|Drug: Ritonavir | Eiger BioPharmaceuticals|Hannover Medical School | Phase 2 | 2015-09-01 | 2016-09-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们