Home > HIV Protease & > Ritonavir

Ritonavir

利托那韦瑞托那韦,ABT-538,A 84538,ABT 538,A-84538,ABT538

Ritonavir是一种HIV蛋白酶抑制剂,用于治疗HIV感染和AIDS。

目录号
EY0394
EY0394
EY0394
EY0394
纯度
99.38%
99.38%
99.38%
99.38%
规格
5 mg
10 mg
50 mg
100 mg
原价
253
445
995
1620
售价
253
445
995
1620
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Eagling VA, et al. Br J Clin Pharmacol, 1997, 44(2), 190-194.

    分子式
    C37H48N6O5S2
    分子量
    720.94
    CAS号
    155213-67-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01074931 HIV-1 Infections Drug: Lopinavir/ritonavir (Kaletra) Abbott 2008-04-01 2011-07-07
    NCT02503462 AIDS-related Dementia Complex Drug: Darunavir|Drug: ritonavir|Drug: cobicistat University Hospital, Basel, Switzerland Phase 4 2015-07-01 2017-02-01
    NCT00985543 Acquired Immunodeficiency Syndrome Drug: lopinavir/ritonavir Kirby Institute Phase 1 2009-10-01 2011-03-02
    NCT01810887 Healthy Drug: Darunavir|Drug: Ritonavir Janssen Pharmaceutical K.K. Phase 4 2008-05-01 2013-04-09
    NCT00885495 HIV Infections Drug: darunavir, ritonavir, rosuvastatin|Drug: rosuvastatin, darunavir, ritonavir University of Cincinnati Phase 1|Phase 2 2009-01-01 2009-04-21
    NCT01047995 HIV Infections Drug: Raltegravir plus Darunavir/ritonavir|Drug: Raltegravir plus Darunavir/ritonavir St Stephens Aids Trust Phase 1 2009-06-01 2010-01-12
    NCT00621166 HIV Infections Drug: generic lopinavir/ritonavir The HIV Netherlands Australia Thailand Research Collaboration Phase 2 2008-06-01 2012-04-03
    NCT00477126 Healthy Drug: GPO ritonavir versus Norvir The HIV Netherlands Australia Thailand Research Collaboration|The Government Pharmaceutical Organization Phase 1 2007-01-01 2012-04-03
    NCT01172535 HIV Drug: Lopinavir/ritonavir National Institute of Allergy and Infectious Diseases (NIAID) Phase 2|Phase 3 2010-11-01 2015-11-16
    NCT02034838 HIV Infection Drug: atazanavir 300mg boosted with ritonavir 50 mg Ottawa Hospital Research Institute|Bristol-Myers Squibb Phase 1 2014-01-01 2015-09-21
    NCT01237444 HIV Infection Drug: lopinavir/ritonavir plus one nucleoside|Drug: lopinavir /ritonavir plus two nucleosides Pedro Cahn|Abbott|The Huesped Foundation Phase 3 2010-12-01 2012-06-08
    NCT01700790 AIDS|Tuberculosis Drug: Lopinavir/ritonavir and ritonavir University of Miami|Oswaldo Cruz Foundation Phase 4 2016-01-01 2016-12-06
    NCT01581853 HIV Drug: Lopinavir/ritonavir 800 mg / 200mg Daniel Podzamczer|Hospital Universitari de Bellvitge Phase 4 2012-05-01 2016-10-05
    NCT02348177 Acquired Immunodeficiency Syndrome|Tuberculosis Drug: lopinavir with ritonavir in 1:1 ratio|Drug: Lopinavir/ritonavir 4:1 Drugs for Neglected Diseases|University of Cape Town|Medecins Sans Frontieres, Netherlands|French Development Agency|UBS Optimus Foundation Phase 4 2013-01-01 2015-01-22
    NCT01002898 HIV Drug: lopinavir/ritonavir soft gel capsule Bamrasnaradura Infectious Diseases Institute Phase 3 2007-04-01 2011-11-10
    NCT01009437 Breast Cancer Drug: ritonavir|Procedure: therapeutic conventional surgery Masonic Cancer Center, University of Minnesota|Susan G. Komen Breast Cancer Foundation Phase 1|Phase 2 2010-05-01 2016-01-21
    NCT01258439 HIV|Cardiovascular Disease Drug: raltegravir plus truvada|Drug: Darunavir, ritonavir, tenofovir/emtricitabine (Truvada) St Vincent's Hospital, Sydney|Merck Sharp & Dohme Corp. Phase 4 2010-11-01 2015-01-08
    NCT01695954 Hyperlipidemia|HIV Drug: Pitavastatin|Drug: Darunavir|Drug: Ritonavir|Drug: Efavirenz New York University School of Medicine|Bellevue/NYU AIDS Clinical Trials Unit|Kowa Pharmaceuticals America, Inc.|University at Buffalo Phase 1 2012-05-01 2012-09-27
    NCT00855413 Acute HIV Infection|HIV Infections Drug: Darunavir/Ritonavir and Etravirine University of North Carolina, Chapel Hill|Janssen Pharmaceuticals Phase 4 2009-03-01 2014-10-14
    NCT02527707 Chronic Delta Hepatitis Drug: lonafarnib|Drug: Ritonavir Eiger BioPharmaceuticals|Hannover Medical School Phase 2 2015-09-01 2016-09-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :