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Natamycin

纳他霉素匹马霉素,Pimaricin

Natamycin 是一种天然存在的三唑类抗真菌药物。

目录号
EY0393
EY0393
EY0393
EY0393
纯度
99.29%
99.29%
99.29%
99.29%
规格
25 mg
50 mg
100 mg
200 mg
原价
312.00
400.00
685.00
1150.00
售价
312.00
400.00
685.00
1150.00
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Natamycinis is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] te Welscher YM, et al. J Biol Chem, 2008, 283(10), 6393-6401.

    分子式
    C33H47NO13
    分子量
    665.73
    CAS号
    7681-93-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    8 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00557362 Fungal Keratitis Drug: Natamycin 5%|Drug: Voriconazole|Procedure: Corneal de-epithelialization University of California, San Francisco|That Man May See, Inc.|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center Phase 1|Phase 2 2007-11-01 2013-11-18
    NCT00996736 Corneal Ulcer|Eye Infections, Fungal Drug: Natamycin|Drug: Voriconazole University of California, San Francisco|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center Phase 3 2010-04-01 2015-03-24
    NCT02731638 Corneal Ulcer|Fungal Keratitis Drug: Intrastromal voriconazole|Drug: Natamycin University of California, San Francisco|Aravind Eye Hospitals, India Phase 3 2016-02-01 2016-12-20
    NCT02328053 Mycotic Corneal Ulcer Procedure: collagen crosslinking group|Drug: Topical anti-fungal therapy Aravind Eye Care System 2014-02-01 2014-12-26
    NCT00516399 Fungal Keratitis Drug: povidone-iodine 1.25% ophthalmic solution|Drug: natamycin ophthalmic suspension, USP 5% University of California, Los Angeles|Los Angeles Biomedical Research Institute Phase 3 2008-03-01 2014-12-03
    NCT02570321 Corneal Ulcer|Infectious Keratitis|Bacterial Ulcer|Fungal Ulcer Procedure: Bacterial ulcer cross-linking|Procedure: Bacterial ulcer control|Procedure: Fungal ulcer cross-linking|Procedure: Fungal ulcer control University of California, San Francisco|Aravind Eye Hospitals, India Phase 4 2015-11-01 2016-12-20
    NCT02865876 Keratitis Procedure: Accelerated Corneal Cross-linking Instituto de Oftalmolog铆a Fundaci贸n Conde de Valenciana|Asociaci贸n para Evitar la Ceguera en M茅xico Phase 3 2015-06-01 2016-08-09
    NCT00997035 Corneal Ulcer|Eye Infections, Fungal Drug: Voriconazole|Drug: Placebo University of California, San Francisco|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center|Lumbini Eye Institute and Hospital|Bharatpur Eye Hospital, Nepal|National Eye Institute (NEI) Phase 3 2010-05-01 2016-06-07

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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