Natamycin 是一种天然存在的三唑类抗真菌药物。
Natamycinis is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] te Welscher YM, et al. J Biol Chem, 2008, 283(10), 6393-6401.
分子式 C33H47NO13 |
分子量 665.73 |
CAS号 7681-93-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 8 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT00557362 | Fungal Keratitis | Drug: Natamycin 5%|Drug: Voriconazole|Procedure: Corneal de-epithelialization | University of California, San Francisco|That Man May See, Inc.|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center | Phase 1|Phase 2 | 2007-11-01 | 2013-11-18 |
NCT00996736 | Corneal Ulcer|Eye Infections, Fungal | Drug: Natamycin|Drug: Voriconazole | University of California, San Francisco|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center | Phase 3 | 2010-04-01 | 2015-03-24 |
NCT02731638 | Corneal Ulcer|Fungal Keratitis | Drug: Intrastromal voriconazole|Drug: Natamycin | University of California, San Francisco|Aravind Eye Hospitals, India | Phase 3 | 2016-02-01 | 2016-12-20 |
NCT02328053 | Mycotic Corneal Ulcer | Procedure: collagen crosslinking group|Drug: Topical anti-fungal therapy | Aravind Eye Care System | 2014-02-01 | 2014-12-26 | |
NCT00516399 | Fungal Keratitis | Drug: povidone-iodine 1.25% ophthalmic solution|Drug: natamycin ophthalmic suspension, USP 5% | University of California, Los Angeles|Los Angeles Biomedical Research Institute | Phase 3 | 2008-03-01 | 2014-12-03 |
NCT02570321 | Corneal Ulcer|Infectious Keratitis|Bacterial Ulcer|Fungal Ulcer | Procedure: Bacterial ulcer cross-linking|Procedure: Bacterial ulcer control|Procedure: Fungal ulcer cross-linking|Procedure: Fungal ulcer control | University of California, San Francisco|Aravind Eye Hospitals, India | Phase 4 | 2015-11-01 | 2016-12-20 |
NCT02865876 | Keratitis | Procedure: Accelerated Corneal Cross-linking | Instituto de Oftalmolog铆a Fundaci贸n Conde de Valenciana|Asociaci贸n para Evitar la Ceguera en M茅xico | Phase 3 | 2015-06-01 | 2016-08-09 |
NCT00997035 | Corneal Ulcer|Eye Infections, Fungal | Drug: Voriconazole|Drug: Placebo | University of California, San Francisco|Aravind Eye Hospitals, India|Dartmouth-Hitchcock Medical Center|Lumbini Eye Institute and Hospital|Bharatpur Eye Hospital, Nepal|National Eye Institute (NEI) | Phase 3 | 2010-05-01 | 2016-06-07 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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