Acyclovir能抑制疱疹病毒的胸苷激酶,IC50为530-750nM。
Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Whitley, R.J. and Gnann, J.W. 1992. N. Engl. J. Med. 327: 782-789. PMID: 1288525
[2] Ochiai, H., et al. 1992. Antiviral Res. 17: 1-16. PMID: 1310580
[3] Tong, X.W., et al. 1998. Anticancer Res. 18: 713-718. PMID: 9615710
[4] Nishimaki, J., et al. 1996. Leuk. Res. 20: 415-420. PMID: 8683981
分子式 C8H11N5O3 |
分子量 225.2 |
CAS号 59277-89-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT00495573 | Genital Herpes | Drug: acyclovir | University of Washington|National Institutes of Health (NIH) | 2007-06-01 | 2012-03-21 | |
NCT00031447 | Herpes Simplex | Drug: Acyclovir|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 | 1999-08-01 | 2012-05-10 |
NCT00031460 | Herpes Simplex | Drug: Acyclovir|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 | 1997-12-01 | 2012-05-10 |
NCT00723229 | Genital Herpes | Drug: acyclovir | University of Washington|National Institutes of Health (NIH) | Phase 4 | 2008-08-01 | 2017-03-06 |
NCT00371592 | HIV Infections|Herpesvirus 2, Human | Drug: Acyclovir|Drug: Acyclovir placebo | National Institute of Allergy and Infectious Diseases (NIAID)|Comprehensive International Program of Research on AIDS | Phase 2 | 2006-09-01 | 2013-09-20 |
NCT00209313 | HIV-1 and HSV-2 Coinfection|HIV Infections | Drug: Acyclovir | Fred Hutchinson Cancer Research Center|Institute for the Development of Africa | Phase 2|Phase 3 | 2005-03-01 | 2011-12-14 |
NCT02053142 | Ulcers of Female Genital Organs | Drug: Acyclovir|Drug: Placebo | University of North Carolina, Chapel Hill|National Institute of Allergy and Infectious Diseases (NIAID) | 2009-01-01 | 2014-12-11 | |
NCT00076232 | HIV Infections|HIV Seronegativity|Herpes Genitalis | Drug: Acyclovir|Drug: Acyclovir placebo | National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute on Drug Abuse (NIDA)|National Institute of Mental Health (NIMH) | Phase 3 | 2005-04-01 | 2010-12-29 |
NCT00942084 | Herpes Simplex Virus|Neonatal Sepsis | Drug: Acyclovir | Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University | Phase 1 | 2011-09-01 | 2013-11-19 |
NCT01327144 | Herpes Zoster | Drug: Famciclovir|Drug: Aciclovir | EMS | Phase 3 | 2012-06-01 | 2017-02-03 |
NCT01714180 | Hematological Malignancy|Pharmacokinetics of Acyclovir | West Virginia University | 2012-10-01 | 2015-06-02 | ||
NCT00711776 | Herpes Labialis | Drug: New formulation|Drug: Current formulation | GlaxoSmithKline | Phase 1 | 2008-04-01 | 2013-03-21 |
NCT00362297 | Genital Herpes | Drug: acyclovir|Drug: valacyclovir | University of Washington | Phase 4 | 2006-09-01 | 2014-10-02 |
NCT01026454 | HSV Infection|HIV Infection | Drug: acyclovir|Drug: valacyclovir | University of Washington | Phase 4 | 2010-02-01 | 2014-03-10 |
NCT01729767 | Meniere's Disease | Drug: Acyclovir|Drug: Placebo | Tehran University of Medical Sciences | Phase 2|Phase 3 | 2011-08-01 | 2012-11-19 |
NCT00855309 | Herpes Simplex | Drug: acyclovir sodium | Wake Forest University Health Sciences|National Cancer Institute (NCI) | Phase 3 | 2008-11-01 | 2017-01-17 |
NCT02255734 | Healthy | Drug: Acyclovir | Yung Shin Pharm. Ind. Co., Ltd. | Phase 4 | 2014-04-01 | 2014-09-29 |
NCT00405821 | HIV Infections|Herpes Genitalis | Drug: Acyclovir|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID)|University of Washington|Johns Hopkins University|Translational Genomics Research Institute|National Institutes of Health Clinical Center (CC) | Phase 2 | 2006-11-01 | 2012-08-28 |
NCT00362596 | HIV|Herpes | Drug: acyclovir | Centers for Disease Control and Prevention|Ministry of Health, Thailand | Phase 4 | 2005-01-01 | 2006-08-09 |
NCT00808405 | Genital Herpes | Drug: acyclovir|Drug: matching placebo | University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health (NIH) | 2009-01-01 | 2013-11-15 | |
NCT01281007 | GENITAL HERPES | Drug: Famciclovir|Drug: Aciclovir | EMS | Phase 3 | 2012-07-01 | 2015-07-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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