Home > HSV & > Aciclovir

Aciclovir

阿昔洛韦,Acyclovir

Acyclovir能抑制疱疹病毒的胸苷激酶,IC50为530-750nM。

目录号
EY0389
EY0389
EY0389
纯度
99.51%
99.51%
99.51%
规格
50 mg
100 mg
500 mg
原价
490
850
1350
售价
490
850
1350
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Aciclovir is a synthetic nucleoside analogue active against herpesviruses.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Whitley, R.J. and Gnann, J.W. 1992. N. Engl. J. Med. 327: 782-789. PMID: 1288525
    [2] Ochiai, H., et al. 1992. Antiviral Res. 17: 1-16. PMID: 1310580
    [3] Tong, X.W., et al. 1998. Anticancer Res. 18: 713-718. PMID: 9615710
    [4] Nishimaki, J., et al. 1996. Leuk. Res. 20: 415-420. PMID: 8683981

    分子式
    C8H11N5O3
    分子量
    225.2
    CAS号
    59277-89-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00495573 Genital Herpes Drug: acyclovir University of Washington|National Institutes of Health (NIH) 2007-06-01 2012-03-21
    NCT00031447 Herpes Simplex Drug: Acyclovir|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 1999-08-01 2012-05-10
    NCT00031460 Herpes Simplex Drug: Acyclovir|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 1997-12-01 2012-05-10
    NCT00723229 Genital Herpes Drug: acyclovir University of Washington|National Institutes of Health (NIH) Phase 4 2008-08-01 2017-03-06
    NCT00371592 HIV Infections|Herpesvirus 2, Human Drug: Acyclovir|Drug: Acyclovir placebo National Institute of Allergy and Infectious Diseases (NIAID)|Comprehensive International Program of Research on AIDS Phase 2 2006-09-01 2013-09-20
    NCT00209313 HIV-1 and HSV-2 Coinfection|HIV Infections Drug: Acyclovir Fred Hutchinson Cancer Research Center|Institute for the Development of Africa Phase 2|Phase 3 2005-03-01 2011-12-14
    NCT02053142 Ulcers of Female Genital Organs Drug: Acyclovir|Drug: Placebo University of North Carolina, Chapel Hill|National Institute of Allergy and Infectious Diseases (NIAID) 2009-01-01 2014-12-11
    NCT00076232 HIV Infections|HIV Seronegativity|Herpes Genitalis Drug: Acyclovir|Drug: Acyclovir placebo National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute on Drug Abuse (NIDA)|National Institute of Mental Health (NIMH) Phase 3 2005-04-01 2010-12-29
    NCT00942084 Herpes Simplex Virus|Neonatal Sepsis Drug: Acyclovir Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University Phase 1 2011-09-01 2013-11-19
    NCT01327144 Herpes Zoster Drug: Famciclovir|Drug: Aciclovir EMS Phase 3 2012-06-01 2017-02-03
    NCT01714180 Hematological Malignancy|Pharmacokinetics of Acyclovir West Virginia University 2012-10-01 2015-06-02
    NCT00711776 Herpes Labialis Drug: New formulation|Drug: Current formulation GlaxoSmithKline Phase 1 2008-04-01 2013-03-21
    NCT00362297 Genital Herpes Drug: acyclovir|Drug: valacyclovir University of Washington Phase 4 2006-09-01 2014-10-02
    NCT01026454 HSV Infection|HIV Infection Drug: acyclovir|Drug: valacyclovir University of Washington Phase 4 2010-02-01 2014-03-10
    NCT01729767 Meniere's Disease Drug: Acyclovir|Drug: Placebo Tehran University of Medical Sciences Phase 2|Phase 3 2011-08-01 2012-11-19
    NCT00855309 Herpes Simplex Drug: acyclovir sodium Wake Forest University Health Sciences|National Cancer Institute (NCI) Phase 3 2008-11-01 2017-01-17
    NCT02255734 Healthy Drug: Acyclovir Yung Shin Pharm. Ind. Co., Ltd. Phase 4 2014-04-01 2014-09-29
    NCT00405821 HIV Infections|Herpes Genitalis Drug: Acyclovir|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID)|University of Washington|Johns Hopkins University|Translational Genomics Research Institute|National Institutes of Health Clinical Center (CC) Phase 2 2006-11-01 2012-08-28
    NCT00362596 HIV|Herpes Drug: acyclovir Centers for Disease Control and Prevention|Ministry of Health, Thailand Phase 4 2005-01-01 2006-08-09
    NCT00808405 Genital Herpes Drug: acyclovir|Drug: matching placebo University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health (NIH) 2009-01-01 2013-11-15
    NCT01281007 GENITAL HERPES Drug: Famciclovir|Drug: Aciclovir EMS Phase 3 2012-07-01 2015-07-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :