Fluoxetine HCl

盐酸氟西汀,盐酸氟西丁,LY-110140,LY 110140,LY110140

Fluoxetine hydrochloride是选择性5羟色胺再吸收抑制剂(SSRI)。

目录号
EY0380
EY0380
EY0380
EY0380
纯度
99.59%
99.59%
99.59%
99.59%
规格
5 mg
10 mg
50 mg
100 mg
原价
220
340
560
725
售价
220
340
560
725
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Malberg JE, et al. Neuropsychopharmacology, 2003, 28(9), 1562-1571.
    [2] Xin-Xian Ye et. Al. Nuclear Medicine and Biology, 31(5), 557-562 (2004).
    [3] Phedias Diamandis et. Al. Nature Chemical Biology, 3(5), 268-273 (2007).

    分子式
    C17H19ClF3NO
    分子量
    345.79
    CAS号
    56296-78-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >5 mg/mL
    Water
    4 mg/mL
    Ethanol
    >5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01361217 Drug-Drug Interaction|Healthy Volunteers Drug: Fluoxetine University of Washington|National Institute of General Medical Sciences (NIGMS) 2011-09-01 2012-06-18
    NCT00986310 Uncontrolled Partial Epilepsy|Ictal Hypoventilation Drug: Fluoxetine|Drug: Placebo University of California, Davis|Citizens United for Research in Epilepsy 2009-08-01 2012-11-02
    NCT00778024 Healthy Drug: fluoxetine HCL 40 mg capsules Ranbaxy Laboratories Limited|Ranbaxy Inc. 2003-08-01 2009-12-11
    NCT01166087 Healthy Drug: Fluoxetine Hydrochloride Dr. Reddy's Laboratories Limited Phase 1 2006-02-01 2010-07-20
    NCT01166100 Healthy Drug: Fluoxetine Hydrochloride Dr. Reddy's Laboratories Limited Phase 1 2006-02-01 2010-07-20
    NCT00115804 Juvenile Primary Fibromyalgia Syndrome (JPFS)|Fibromyalgia Drug: Fluoxetine University of Cincinnati Phase 3 2005-06-01 2017-02-06
    NCT02569970 Epilepsy|Ictal/Post-ictal Hypoxemia Drug: fluoxetine 20 mg|Drug: placebo 20 mg Hospices Civils de Lyon Phase 3 2010-11-01 2016-10-04
    NCT01146548 Multiple System Atrophy Drug: FLUOXETINE University Hospital, Toulouse|Clinical Research Center, Toulouse Phase 2 2008-05-01 2015-03-25
    NCT00149643 Depressive Disorder, Major|Cannabis Abuse Drug: Fluoxetine|Other: Placebo University of Pittsburgh|National Institute on Drug Abuse (NIDA) Phase 2 2004-09-01 2013-06-17
    NCT00633685 Posttraumatic Stress Disorder, Combat-related Drug: Fluoxetine|Drug: Placebo TEMPVA Research Group, Inc.|C.R.Darnall Army Medical Center|Central Texas Veterans Health Care System|VA Boston Healthcare System Phase 4 2010-03-01 2010-05-24
    NCT00573547 Depression Drug: Fluoxetine Creighton University Phase 4 2007-02-01 2011-08-15
    NCT00245635 Body Dysmorphic Disorder Drug: Fluoxetine|Drug: Placebo Montefiore Medical Center|Food and Drug Administration (FDA) Phase 4 2004-11-01 2015-07-06
    NCT01615055 Cognitive Dysfunction Drug: Fluoxetine|Drug: Placebo University of California, Los Angeles|Beckman Research Institute 2018-06-01 2016-02-04
    NCT00183339 Autistic Disorder Drug: Fluoxetine|Drug: Placebo University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) Phase 2 2005-07-01 2014-02-07
    NCT01247272 Healthy Drug: Fluoxetine Hydrochloride|Drug: PROZAC WEEKLY庐 Teva Pharmaceuticals USA Phase 1 2001-05-01 2011-01-24
    NCT01247285 Healthy Drug: Fluoxetine Hydrochloride|Drug: PROZAC WEEKLY庐 Teva Pharmaceuticals USA Phase 1 2001-05-01 2011-01-24
    NCT01075529 Major Depressive Disorder Drug: fluoxetine Kaohsiung Kai-Suan Psychiatric Hospital Phase 4 2007-03-01 2010-02-24
    NCT02063425 Cerebral Infarction Drug: Fluoxetine|Drug: Placebo of fluoxetine Centre Hospitalier St Anne 2014-02-01 2016-02-11
    NCT02737930 Acute Stroke|Visual Field Loss Drug: Fluoxetine|Drug: Placebo Bogachan Sahin|University of Rochester Phase 2 2016-05-01 2016-10-25
    NCT00758966 Obsessive-Compulsive Disorder Drug: Fluoxetine 60 mg|Drug: Naltrexone 32 mg and fluoxetine 60 mg|Drug: Naltrexone SR 32 mg Orexigen Therapeutics, Inc Phase 2 2008-09-01 2012-11-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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