Fluoxetine hydrochloride是选择性5羟色胺再吸收抑制剂(SSRI)。
Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Malberg JE, et al. Neuropsychopharmacology, 2003, 28(9), 1562-1571.
[2] Xin-Xian Ye et. Al. Nuclear Medicine and Biology, 31(5), 557-562 (2004).
[3] Phedias Diamandis et. Al. Nature Chemical Biology, 3(5), 268-273 (2007).
分子式 C17H19ClF3NO |
分子量 345.79 |
CAS号 56296-78-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >5 mg/mL |
Water 4 mg/mL |
Ethanol >5 mg/mL |
体内溶解度
NCT01361217 | Drug-Drug Interaction|Healthy Volunteers | Drug: Fluoxetine | University of Washington|National Institute of General Medical Sciences (NIGMS) | 2011-09-01 | 2012-06-18 | |
NCT00986310 | Uncontrolled Partial Epilepsy|Ictal Hypoventilation | Drug: Fluoxetine|Drug: Placebo | University of California, Davis|Citizens United for Research in Epilepsy | 2009-08-01 | 2012-11-02 | |
NCT00778024 | Healthy | Drug: fluoxetine HCL 40 mg capsules | Ranbaxy Laboratories Limited|Ranbaxy Inc. | 2003-08-01 | 2009-12-11 | |
NCT01166087 | Healthy | Drug: Fluoxetine Hydrochloride | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-02-01 | 2010-07-20 |
NCT01166100 | Healthy | Drug: Fluoxetine Hydrochloride | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-02-01 | 2010-07-20 |
NCT00115804 | Juvenile Primary Fibromyalgia Syndrome (JPFS)|Fibromyalgia | Drug: Fluoxetine | University of Cincinnati | Phase 3 | 2005-06-01 | 2017-02-06 |
NCT02569970 | Epilepsy|Ictal/Post-ictal Hypoxemia | Drug: fluoxetine 20 mg|Drug: placebo 20 mg | Hospices Civils de Lyon | Phase 3 | 2010-11-01 | 2016-10-04 |
NCT01146548 | Multiple System Atrophy | Drug: FLUOXETINE | University Hospital, Toulouse|Clinical Research Center, Toulouse | Phase 2 | 2008-05-01 | 2015-03-25 |
NCT00149643 | Depressive Disorder, Major|Cannabis Abuse | Drug: Fluoxetine|Other: Placebo | University of Pittsburgh|National Institute on Drug Abuse (NIDA) | Phase 2 | 2004-09-01 | 2013-06-17 |
NCT00633685 | Posttraumatic Stress Disorder, Combat-related | Drug: Fluoxetine|Drug: Placebo | TEMPVA Research Group, Inc.|C.R.Darnall Army Medical Center|Central Texas Veterans Health Care System|VA Boston Healthcare System | Phase 4 | 2010-03-01 | 2010-05-24 |
NCT00573547 | Depression | Drug: Fluoxetine | Creighton University | Phase 4 | 2007-02-01 | 2011-08-15 |
NCT00245635 | Body Dysmorphic Disorder | Drug: Fluoxetine|Drug: Placebo | Montefiore Medical Center|Food and Drug Administration (FDA) | Phase 4 | 2004-11-01 | 2015-07-06 |
NCT01615055 | Cognitive Dysfunction | Drug: Fluoxetine|Drug: Placebo | University of California, Los Angeles|Beckman Research Institute | 2018-06-01 | 2016-02-04 | |
NCT00183339 | Autistic Disorder | Drug: Fluoxetine|Drug: Placebo | University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) | Phase 2 | 2005-07-01 | 2014-02-07 |
NCT01247272 | Healthy | Drug: Fluoxetine Hydrochloride|Drug: PROZAC WEEKLY庐 | Teva Pharmaceuticals USA | Phase 1 | 2001-05-01 | 2011-01-24 |
NCT01247285 | Healthy | Drug: Fluoxetine Hydrochloride|Drug: PROZAC WEEKLY庐 | Teva Pharmaceuticals USA | Phase 1 | 2001-05-01 | 2011-01-24 |
NCT01075529 | Major Depressive Disorder | Drug: fluoxetine | Kaohsiung Kai-Suan Psychiatric Hospital | Phase 4 | 2007-03-01 | 2010-02-24 |
NCT02063425 | Cerebral Infarction | Drug: Fluoxetine|Drug: Placebo of fluoxetine | Centre Hospitalier St Anne | 2014-02-01 | 2016-02-11 | |
NCT02737930 | Acute Stroke|Visual Field Loss | Drug: Fluoxetine|Drug: Placebo | Bogachan Sahin|University of Rochester | Phase 2 | 2016-05-01 | 2016-10-25 |
NCT00758966 | Obsessive-Compulsive Disorder | Drug: Fluoxetine 60 mg|Drug: Naltrexone 32 mg and fluoxetine 60 mg|Drug: Naltrexone SR 32 mg | Orexigen Therapeutics, Inc | Phase 2 | 2008-09-01 | 2012-11-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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