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Tripelennamine HCl

盐酸曲吡那敏,Pyribenzamine HCl

Tripelennamine盐酸盐是H1受体拮抗剂。

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生物活性

Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.
体外研究
体内研究
激酶实验
细胞实验
动物实验
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] Styczynski PB, et al. Chem Res Toxicol, 1993, 6(6), 846-851.
[2] C C Kuo et. Al. Molecular Pharmacology, 57(1), 135-143 (2000).

分子式 C16H22ClN3	分子量 291.82	CAS号 154-69-8	储存方式 ﹣20 ℃冷藏长期储存。冰袋运输
溶剂（常温）	DMSO 2 mg/mL	Water 55 mg/mL	Ethanol <1 mg/mL

体内溶解度

NCT00620945	Congenital Heart Surgery\|Cardiopulmonary Bypass	Drug: Phenoxybenzamine	The Cleveland Clinic		2006-06-01	2008-02-11
NCT00620217	Coronary Artery Disease	Genetic: intramyocardial injection of VEGF-A165/bFGF:placebo plasmid	Institute of Cardiology, Warsaw, Poland\|Center of Oncology, Warsaw, Poland\|Medical University of Warsaw\|Ministry of Scientific Research and Information Technology, Poland\|Polpharma Foundation for Development of Polish Pharmacy and Medicine	Phase 2	2004-12-01	2009-11-27
NCT01861548	Asthma\|Atopic Dermatitis\|Food Allergy\|Wheezing		Medical Universtity of Lodz		2007-01-01	2013-05-21
NCT00316381	Myocardial Infarction	Procedure: Autologous bone marrow-derived stem cells	Silesian School of Medicine\|Ministry of Science and Higher Education, Poland		2004-11-01	2008-05-20

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。