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Carbidopa

卡比多巴

Carbidopa (卡比多巴) 是多巴脱羧酶抑制剂,可作用于帕金森症。

目录号
EY0365
EY0365
EY0365
纯度
99.42%
99.42%
99.42%
规格
5 mg
10 mg
50 mg
原价
310
470
960
售价
310
470
960
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Deleu, D., et al. 1993. Naunyn Schmiedebergs Arch. Pharmacol. 348: 576-581. PMID: 8133901
    [2] Henry, G.M., et al. 1976. Psychosom Med. 38: 95-105. PMID: 1273240
    [3] Sethi, K.D. 2010. Neurologist. 16: 76-83. PMID: 20220441
    [4] Leguire, L.E., et al. 1993. Invest. Ophthalmol. Vis. Sci. 34: 3090-3095. PMID: 8407216

    分子式
    C10H14N2O4
    分子量
    226.23
    CAS号
    28860-95-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    3 mg/mL
    Water
    1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01212484 Familial Dysautonomia Drug: Carbidopa|Drug: Placebo New York University School of Medicine Phase 3 2009-12-01 2016-03-07
    NCT00829439 Angelman Syndrome Drug: Levodopa/Carbidopa (4:1) Boston Children鈥檚 Hospital Phase 1 2009-01-01 2016-09-29
    NCT01399905 Parkinson's Disease Drug: carbidopa Oregon Health and Science University Phase 2 2009-03-01 2011-07-21
    NCT02486432 Parkinson's Disease Drug: Levodopa/Carbidopa (Sinemet) NeuroDerm Ltd.|Quotient Clinical Phase 1 2015-04-01 2015-06-28
    NCT00391898 Parkinson's Disease Drug: Levodopa/carbidopa/entacapone|Drug: Levodopa/carbidopa Novartis Phase 4 2006-10-01 2011-02-16
    NCT00745277 Parkinson's Disease Drug: Carbidopa-Levodopa|Drug: Carbidopa- Levodopa Oregon Health and Science University|Parkinson Disease Research, Education and Clinical Center at Portland VA Hospital|RJG Foundation|Oregon Clinical and Translational Research Institute Phase 2 2008-08-01 2012-11-28
    NCT01229332 Parkinson's Disease Drug: Saline|Drug: Carbidopa NeuroDerm Ltd. Phase 1|Phase 2 2011-01-01 2011-12-04
    NCT02553265 Dysautonomia, Familial|Baroreflex Failure Syndrome Drug: Carbidopa Low Dose|Other: Placebo|Drug: Carbidopa High Dose New York University School of Medicine Phase 2 2015-09-01 2016-12-28
    NCT00099268 Parkinson's Disease Drug: Carbidopa/levodopa/entacapone|Drug: Immediate release carbidopa/levodopa Novartis Pharmaceuticals|Orion Corporation, Orion Pharma|Novartis Phase 3 2004-09-01 2012-04-19
    NCT02116465 Fasted State Drug: Levodopa Carbidopa immediate release tablets Desitin Arzneimittel GmbH Phase 1 2014-03-01 2014-04-14
    NCT00558337 Parkinson's Disease Drug: levodopa-carbidopa Osmotica Pharmaceutical US LLC Phase 2 2007-11-01 2009-01-13
    NCT00642356 Parkinson's Disease Drug: Carbidopa/levodopa/entacapone|Drug: Immediate release carbidopa/levodopa Novartis Phase 4 2008-03-01 2011-02-16
    NCT00547911 Parkinson Disease|Multiple System Atrophy|Autonomic Nervous System Diseases Drug: Droxidopa|Drug: Carbidopa|Drug: Entacapone National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2007-10-01 2014-06-17
    NCT03023059 Age-related Macular Degeneration Drug: Carbidopa-Levodopa, 25 Mg-100 Mg Oral Tablet Snyder, Robert W., M.D., Ph.D., P.C. Phase 2 2017-03-01 2017-01-17
    NCT01736176 Advanced Parkinson's Disease Drug: Levodopa-Carbidopa Intestinal Gel|Procedure: Percutaneous Endoscopic Gastrostomy with Jejunal Extension (PEG-J)|Drug: Levodopa-carbidopa Immediate Release (LC-IR) Tablets AbbVie (prior sponsor, Abbott)|AbbVie Phase 3 2013-03-01 2016-12-16
    NCT01323374 Fibromyalgia Drug: Droxidopa|Drug: Carbidopa|Drug: Droxidopa/carbidopa|Drug: Placebo Chelsea Therapeutics Phase 2 2009-01-01 2012-07-18
    NCT00983814 Attention Deficit Hyperactivity Disorder Drug: Droxidopa+Carbidopa|Drug: Placebo Chelsea Therapeutics Phase 2 2009-10-01 2013-03-27
    NCT00219284 Parkinson's Disease With End of Dose "Wearing Off" Drug: Carbidopa/levodopa/entacapone Novartis Pharmaceuticals|Novartis Phase 4 2005-01-01 2011-02-16
    NCT02812394 Parkinson Disease Drug: CVT-301 (Dose Level 1)|Drug: CVT-301 (Dose Level 2)|Drug: Sinemet庐 Acorda Therapeutics Phase 1 2016-06-01 2016-10-24
    NCT00415740 Healthy Drug: ELC200 (carbidopa+levodopa+entacapone) Novartis Phase 1 2006-05-01 2007-06-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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