Home > Antibacterial & > Chloramphenicol

Chloramphenicol

氯霉素,氯胺苯醇,Chloromycetin

Chloramphenicol是广谱抗菌剂。

目录号
EY0362
EY0362
纯度
99.41%
99.41%
规格
100 mg
500 mg
原价
250
390
售价
250
390
库存
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Chloramphenicol is a bacteriostatic by inhibiting protein synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Jiang W, et al. J Bacteriol, 1993, 175(18), 5824-5828.
    [2] Ji-Young Park,et al. Chloramphenicol Is a Potent Inhibitor of Cytochrome P450 Isoforms CYP2C19 and CYP3A4 in Human Liver Microsomes. Antimicrob Agents Chemother. 2003 Nov; 47(11): 3464–3469. doi: 10.1128/AAC.47.11.3464-3469.2003.
    [3] Katherine S.et al. An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway. Nucleic Acids Res. 2003 Dec 15; 31(24): 7208–7215. doi: 10.1093/nar/gkg945.

    分子式
    C11H12Cl2N2O5    		 分子量
    323.13    		 CAS号
    56-75-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    60 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00372541 Pneumonia Drug: ceftriaxone Makerere University Phase 3 2006-09-01 2010-07-23
    NCT01168375 Corneal Epithelial Defect Drug: conventional therapy plus umbilical cord serum eye drop|Drug: conventional therapy Shahid Beheshti University of Medical Sciences|Ophthalmic Research Center Phase 1 null 2010-07-22
    NCT01010451 Inflammation|Necrosis Procedure: Antimicrobial pulpotomy|Procedure: Calcium hydroxide pulpectomy Universidade Federal de Goias Phase 4 2000-08-01 2009-11-09
    NCT01969786 Corneal Ulcer Other: Corneal ulcer prevention program University of California, San Francisco|National Eye Institute (NEI)|Seva Foundation|Bharatpur Eye Hospital 2014-02-01 2016-12-05
    NCT00850148 Keratoconus Procedure: Anwar|Procedure: Melles Shahid Beheshti University of Medical Sciences 2008-05-01 2012-01-04
    NCT00579956 Melioidosis Drug: Meropenem|Drug: Ceftazidime University of Oxford|Mahidol University|Wellcome Trust 2007-12-01 2008-06-03
    NCT03083197 Scrub Typhus Drug: Doxycycline 7 days|Drug: Doxycycline 3 days|Drug: Azithromycin 3 days University of Oxford|Shoklo Malaria Research Unit|Chiangrai Prachanukroh Hospital Phase 4 2017-05-15 2017-03-20
    NCT00386789 Typhoid Fever Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) 2006-10-05 2017-01-24
    NCT00619203 Bacterial Meningitis Drug: Glycerol and paracetamol|Drug: Paracetamol|Drug: Paracetamol|Drug: Paracetamol|Drug: Placebo|Drug: Paracetamol and glycerol|Drug: Glycerol University of Malawi College of Medicine Phase 3 2008-03-01 2012-07-09
    NCT00704977 Pterygium Procedure: pterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique Soroka University Medical Center 2008-06-01 2008-06-24
    NCT02099240 Osteomyelitis Drug: oral antibiotics|Procedure: intravenous antibiotics Julio Ramirez|James Graham Brown Cancer Center|University of Louisville Early Phase 1 2014-04-01 2017-03-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：