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Glyburide

格列本脲,Glibenclamide

Glibenclamide是磺酰脲类化合物，能调节胰岛素的产生。

目录号
EY0360
EY0360
纯度
99.39%
99.39%
规格
100 mg
500 mg
原价
134
386
售价
134
386
库存
现货
现货
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  • 生物活性

    Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Winquist RJ, et al. J Pharmacol Exp Ther,?989, 248(1), 149-156.
    [2] Marilia Trindade de Santana et. Al. Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice. Pharmaceutical Biology, 51(9), 1144-1149 (2013).
    [3] A Chrabi and J D Horisberger. Stimulation of epithelial sodium channel activity by the sulfonylurea glibenclamide. Journal of Pharmacology and Experimental Therapeutics, 290(1), 341-347 (1999).
    [4] Gaetano Santulli et. Al. Calcium release channel RyR2 regulates insulin release and glucose homeostasis. Journal of Clinical Investigation, 125(5), 1968-1978 (2015).

    分子式
    C23H28ClN3O5S    		 分子量
    494    		 CAS号
    10238-21-8     		储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    25 mg/mL    		 Water
    Insoluble    		 Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02726490 Gestational Diabetes Drug: Glyburide|Drug: Glucovance Texas Tech University Health Sciences Center, El Paso 2016-07-01 2016-07-07
    NCT01733108 Healthy Drug: Glyburide|Drug: Canagliflozin (JNJ-28431754) Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2008-07-01 2012-12-11
    NCT01454154 Traumatic Brain Injury Drug: Glyburide|Drug: Placebo Remedy Pharmaceuticals, Inc.|U.S. Army Medical Research and Materiel Command|INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium Phase 2 2011-11-01 2015-05-05
    NCT02815787 Type 2 Diabetes Drug: SP2086|Drug: Glyburide Jiangsu HengRui Medicine Co., Ltd. Phase 1 2014-03-01 2016-06-23
    NCT01716338 Healthy Volunteers Drug: Glyburide|Drug: Placebo Washington University School of Medicine|United States Department of Defense|University of Maryland Phase 1 2013-01-01 2014-09-15
    NCT01794182 Ischemic Stroke|Malignant Edema Drug: RP-1127 (Glyburide for Injection) Remedy Pharmaceuticals, Inc. Phase 2 2013-05-01 2015-05-31
    NCT00451620 Type 2 Diabetes Drug: glyburide|Drug: GlucoNorm University of British Columbia|Novo Nordisk A/S Phase 2 2003-11-01 2014-02-17
    NCT01268683 Ischemic Stroke Drug: RP-1127 (Glyburide for injection) Remedy Pharmaceuticals, Inc.|University of Maryland|Massachusetts General Hospital Phase 1|Phase 2 2011-05-01 2014-05-14
    NCT02460874 Cerebral Edema|Brain Metastases Drug: Glyburide|Other: Placebo University of Maryland Phase 1|Phase 2 2016-12-01 2016-10-24
    NCT01456650 Type 2 Diabetes Drug: Glyburide Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Phase 4 2011-03-01 2014-01-14
    NCT00865436 Healthy Drug: Glyburide and Metformin Hydrochloride Tablets 5 mg/500 mg|Drug: CLUCOVANCE庐 5 mg/500 mg Tablets, single dose Actavis Inc. Phase 1 2004-04-01 2010-08-13
    NCT00865241 Healthy Drug: Glyburide and Metformin Hydrochloride Tablets 5 mg/500 mg|Drug: CLUCOVANCE庐 5 mg/500 mg Tablets, single dose Actavis Inc. Phase 1 2002-11-01 2010-08-13
    NCT00864734 Healthy Drug: Glyburide and Metformin Hydrochloride Tablets 5 mg/500 mg|Drug: CLUCOVANCE庐 5 mg/500 mg Tablets, single dose Actavis Inc. Phase 1 2002-11-01 2010-08-13
    NCT00965991 Gestational Diabetes Drug: metformin|Drug: Glyburide University of New Mexico 2003-07-01 2010-06-23
    NCT02183428 Healthy Drug: BI 1356|Drug: Glyburide|Drug: BI 1356 + Glyburide Boehringer Ingelheim Phase 1 2008-05-01 2014-07-04
    NCT00835991 Healthy Drug: Glyburide/Metformin 5 mg/500 mg Tablets|Drug: Glucovance庐 5 mg/500 mg Tablets Teva Pharmaceuticals USA Phase 1 2003-02-01 2009-09-01
    NCT00836472 Healthy Drug: Glyburide/Metformin 5 mg/500 mg Tablets|Drug: Glucovance庐 5 mg/500 mg Tablets Teva Pharmaceuticals USA Phase 1 2003-04-01 2009-09-01
    NCT00744965 Mild Gestational Diabetes Drug: Glyburide|Drug: Placebo University of Texas Southwestern Medical Center Phase 4 2008-08-01 2017-01-25
    NCT00759720 Diabetes Mellitus Drug: TAK-559 and glyburide|Drug: TAK-559 and glyburide|Drug: Glyburide Takeda Phase 3 2003-11-01 2012-02-01
    NCT00279045 Diabetes Mellitus, Type 2 Drug: Rosiglitazone|Drug: glyburide|Drug: metformin GlaxoSmithKline Phase 3 2000-01-01 2017-03-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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