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Streptozotocin

链脲菌素,链唑霉素,NSC 85998,NSC-85998,STZ,NSC85998,

Streptozotocin是DNA烷化剂,能通过GLUT2进入细胞，对产生胰岛素的β细胞和GLUT2阳性神经内分泌肿瘤细胞有特异毒性。

目录号
EY0348
EY0348
EY0348
纯度
99.27%
99.27%
99.27%
规格
50 mg
100 mg
500 mg
原价
390
680
1800
售价
390
680
1800
库存
现货
现货
现货
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  • 生物活性

    Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Tong-Song Wang et. Al. Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model. Biology Open, 4(7), 893-902 (2015).
    [2] Swapnil B Patil et. Al. Insulinotropic and β-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats. British Journal of Nutrition, 110(8), 1434-1443 (2013).
    [3] Vidhya R Rao et. Al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR). Investigative Ophthalmology & Visual Science, 51(10), 5198-5204 (2010).

    分子式
    C8H15N3O7    		 分子量
    265.22    		 CAS号
    18883-66-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    ≥53 mg/mL    		 Water
    ≥53 mg/mL    		 Ethanol
    ≥3 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00001165 Islet Cell Adenoma|Neoplasm Metastasis|Zollinger Ellison Syndrome Drug: combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 1978-09-01 2008-03-03
    NCT00609765 Pancreatic Cancer Drug: Avastin|Drug: Fluorouracil|Drug: Doxorubicin|Drug: Streptozocin|Drug: Dexamethasone|Drug: Ondansetron H. Lee Moffitt Cancer Center and Research Institute|Genentech, Inc. Phase 2 2007-08-01 2017-02-20
    NCT00602082 Gastrointestinal Carcinoid Tumor|Islet Cell Tumor Drug: capecitabine|Drug: cisplatin|Drug: streptozocin|Genetic: DNA analysis|Genetic: RNA analysis|Genetic: protein analysis|Genetic: proteomic profiling|Other: laboratory biomarker analysis Cambridge University Hospitals NHS Foundation Trust|National Cancer Institute (NCI) Phase 2 2005-08-01 2013-08-06
    NCT00004688 Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Mixed Gliomas|Glioblastoma Multiforme|Recurrent Brain Tumor Drug: carmustine|Drug: mercaptopurine|Drug: streptozocin Emory University|FDA Office of Orphan Products Development Phase 2 1996-08-01 2015-03-24
    NCT02246127 Pancreatic Neuroendocrine Tumours. Drug: Drug: Everolimus|Drug: STZ-5FU Grupo Espanol de Tumores Neuroendocrinos|European Neuroendocrine Tumor Society|Kantar Health|Novartis Pharmaceuticals Phase 3 2014-10-01 2015-11-03
    NCT00094497 Carcinoma, Adrenal Cortical Drug: Etoposide|Drug: Doxorubicin|Drug: Cisplatin|Drug: Streptozotocin|Drug: Mitotane Collaborative Group for Adrenocortical Carcinoma Treatment|German Federal Ministry of Education and Research|National Cancer Institute (NCI) Phase 3 2004-06-01 2016-09-19
    NCT00448136 Neoplasms Drug: bevacizumab [Avastin]|Drug: 5 FU|Drug: Streptozotocin|Drug: Xeloda Hoffmann-La Roche Phase 2 2007-07-01 2015-01-20
    NCT00633763 Type1 Diabetes Mellitus Drug: 18F-fallypride|Drug: 18F-fallypride University of California, Irvine|Juvenile Diabetes Research Foundation 2008-02-01 2009-05-27
    NCT01709123 Diabetes Mellitus, Type 1 Drug: chromium niacinate|Drug: placebo Louisiana State University Health Sciences Center Shreveport|National Institutes of Health (NIH)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2007-08-01 2012-10-29
    NCT00003543 Colorectal Cancer Biological: monoclonal antibody A33|Drug: carmustine|Drug: fluorouracil|Drug: streptozocin|Drug: vincristine sulfate Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Phase 1 1998-06-01 2013-06-25
    NCT01362530 Chemotherapy Induced Nausea and Vomiting Drug: Aprepitant 125 mg|Drug: Aprepitant 80 mg|Drug: Aprepitant powder for suspension (PFS)|Drug: Ondansetron|Drug: Placebo for Aprepitant 125 mg|Drug: Placebo for Aprepitant 80 mg|Drug: Placebo for Aprepitant PFS|Drug: Emetogenic chemotherapy Merck Sharp & Dohme Corp. Phase 3 2011-09-01 2015-04-17

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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