Ranolazine具有抗心律失常活性。
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Michels, G., et al. 2010. Dtsch. Med. Wochenschr. 135: 2037-2040. PMID: 20925013
[2] Schofield, R.S. and Hill, J.A. 2002. Expert Opin Investig Drugs. 11: 117-123. PMID: 11772326
[3] Mito, M.S., et al. 2010. Mol. Cell. Biochem. 345: 35-44. PMID: 20680408
[4] McCormack, J.G., et al. 1998. Gen. Pharmacol. 30: 639-645. PMID: 9559312
分子式 C24H33N3O4 |
分子量 427.54 |
CAS号 95635-55-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 85 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT02360397 | Ventricular Premature Complexes|Myocardial Ischemia | Drug: ranolazine | Kent Hospital, Rhode Island|Gilead Sciences | Phase 2 | 2014-12-01 | 2016-09-01 |
NCT02239926 | Diarrhea Predominant Irritable Bowel Syndrome | Drug: Ranolazine|Drug: Placebo | Mayo Clinic | Phase 2|Phase 3 | 2014-09-01 | 2016-02-16 |
NCT01705509 | Cardiomyopathy | Drug: Ranolazine | Cardiovascular Institute of the South Clinical Research Corporation|Gilead Sciences | 2012-09-01 | 2016-01-26 | |
NCT01996618 | Premature Ventricular Beats | Drug: Ranolazine | Walter Reed National Military Medical Center | Phase 4 | 2014-01-01 | 2015-04-30 |
NCT01435174 | End-stage Renal Disease|Cardiovascular Disease | Drug: Ranolazine|Procedure: Pharmacokinetic Blood and Dialysate Sampling|Procedure: QT Interval | University of Michigan|Gilead Sciences | Phase 4 | 2011-10-01 | 2014-06-24 |
NCT02251457 | Myotonia Congenita (Enrollment Complete)|Paramyotonia Congenita|Myotonic Dystrophy 1 | Drug: Ranolazine | Ohio State University|Gilead Sciences | Phase 2 | 2014-08-01 | 2017-03-18 |
NCT02133352 | Pulmonary Hypertension|Diastolic Left Ventricular Dysfunction | Drug: Ranolazine | Harrison Farber|Gilead Sciences|Boston University | Phase 4 | 2011-07-01 | 2014-05-06 |
NCT01304095 | Coronary Artery Disease|Angina|Metabolic Syndrome | Drug: Ranolazine | Atlanta Heart Specialists, LLC|Gilead Sciences | Phase 4 | 2011-01-01 | 2013-07-09 |
NCT01546597 | Type 2 Diabetes Mellitus | Drug: Metformin|Drug: Ranolazine | Gilead Sciences | Phase 1 | 2012-02-01 | 2012-07-09 |
NCT02252406 | Stable Angina|Metabolic Syndrome | Drug: Ranolazine|Drug: Placebo | University of Florida | Phase 4 | 2015-09-01 | 2017-02-02 |
NCT01546558 | Type 2 Diabetes Mellitus | Drug: Metformin|Drug: Ranolazine | Gilead Sciences | Phase 1 | 2012-02-01 | 2012-07-09 |
NCT02156336 | Diabetic Peripheral Neuropathic Pain | Drug: Ranolazine|Drug: Placebo | Horizons International Peripheral Group|Gilead Sciences | Phase 4 | 2014-05-01 | 2017-02-09 |
NCT01174173 | Angina|Pulmonary Arterial Hypertension | Drug: Ranolazine | Northwestern University|Gilead Sciences | Phase 3 | 2010-06-01 | 2015-04-22 |
NCT01767987 | Acute Coronary Syndrome | Drug: Ranolazine|Drug: Placebo | Harvey Hahn|Gilead Sciences|Kettering Health Network | Phase 2 | 2012-11-01 | 2015-10-20 |
NCT02147067 | Microvascular Angina | Drug: Ranolazine|Drug: Placebo | Emory University|Gilead Sciences | Phase 4 | 2014-09-01 | 2016-07-27 |
NCT01558830 | Chronic Stable Angina|Coronary Artery Disease|Atrial Fibrillation|Ventricular Tachycardia | Drug: ranolazine|Drug: placebo | Cardiovascular Consultants of Nevada|Gilead Sciences | Phase 4 | 2012-01-01 | 2012-03-20 |
NCT01721967 | Hypertrophic Cardiomyopathy | Drug: Ranolazine | Duke University|Gilead Sciences | Phase 4 | 2012-11-01 | 2017-01-19 |
NCT03044964 | Angina | Drug: Ranolazine|Drug: Placebo | Amit Malhotra, MD|Gilead Sciences|Stern Cardiovascular Foundation, Inc. | Phase 4 | 2017-01-10 | 2017-02-03 |
NCT01345188 | Cardiomyopathy|Chest Pain|Dyspnea | Drug: Ranexa|Drug: Placebo | Midwest Cardiovascular Research Foundation|Gilead Sciences | Phase 4 | 2011-04-01 | 2014-09-24 |
NCT01163721 | Diabetes Mellitus, Type 2 | Drug: Ranolazine|Drug: Placebo | Gilead Sciences | Phase 2 | 2010-06-01 | 2013-07-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们