Ranolazine

雷诺嗪,CVT 303,RS 43285-003,Ranexa,CVT303,CVT-303,

Ranolazine具有抗心律失常活性。

目录号
EY0345
EY0345
EY0345
纯度
99.48%
99.48%
99.48%
规格
25 mg
100 mg
500 mg
原价
498.00
756.00
2000
售价
498.00
756.00
2000
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Michels, G., et al. 2010. Dtsch. Med. Wochenschr. 135: 2037-2040. PMID: 20925013
    [2] Schofield, R.S. and Hill, J.A. 2002. Expert Opin Investig Drugs. 11: 117-123. PMID: 11772326
    [3] Mito, M.S., et al. 2010. Mol. Cell. Biochem. 345: 35-44. PMID: 20680408
    [4] McCormack, J.G., et al. 1998. Gen. Pharmacol. 30: 639-645. PMID: 9559312

    分子式
    C24H33N3O4
    分子量
    427.54
    CAS号
    95635-55-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    85 mg/mL
    Water
    <1 mg/mL
    Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02360397 Ventricular Premature Complexes|Myocardial Ischemia Drug: ranolazine Kent Hospital, Rhode Island|Gilead Sciences Phase 2 2014-12-01 2016-09-01
    NCT02239926 Diarrhea Predominant Irritable Bowel Syndrome Drug: Ranolazine|Drug: Placebo Mayo Clinic Phase 2|Phase 3 2014-09-01 2016-02-16
    NCT01705509 Cardiomyopathy Drug: Ranolazine Cardiovascular Institute of the South Clinical Research Corporation|Gilead Sciences 2012-09-01 2016-01-26
    NCT01996618 Premature Ventricular Beats Drug: Ranolazine Walter Reed National Military Medical Center Phase 4 2014-01-01 2015-04-30
    NCT01435174 End-stage Renal Disease|Cardiovascular Disease Drug: Ranolazine|Procedure: Pharmacokinetic Blood and Dialysate Sampling|Procedure: QT Interval University of Michigan|Gilead Sciences Phase 4 2011-10-01 2014-06-24
    NCT02251457 Myotonia Congenita (Enrollment Complete)|Paramyotonia Congenita|Myotonic Dystrophy 1 Drug: Ranolazine Ohio State University|Gilead Sciences Phase 2 2014-08-01 2017-03-18
    NCT02133352 Pulmonary Hypertension|Diastolic Left Ventricular Dysfunction Drug: Ranolazine Harrison Farber|Gilead Sciences|Boston University Phase 4 2011-07-01 2014-05-06
    NCT01304095 Coronary Artery Disease|Angina|Metabolic Syndrome Drug: Ranolazine Atlanta Heart Specialists, LLC|Gilead Sciences Phase 4 2011-01-01 2013-07-09
    NCT01546597 Type 2 Diabetes Mellitus Drug: Metformin|Drug: Ranolazine Gilead Sciences Phase 1 2012-02-01 2012-07-09
    NCT02252406 Stable Angina|Metabolic Syndrome Drug: Ranolazine|Drug: Placebo University of Florida Phase 4 2015-09-01 2017-02-02
    NCT01546558 Type 2 Diabetes Mellitus Drug: Metformin|Drug: Ranolazine Gilead Sciences Phase 1 2012-02-01 2012-07-09
    NCT02156336 Diabetic Peripheral Neuropathic Pain Drug: Ranolazine|Drug: Placebo Horizons International Peripheral Group|Gilead Sciences Phase 4 2014-05-01 2017-02-09
    NCT01174173 Angina|Pulmonary Arterial Hypertension Drug: Ranolazine Northwestern University|Gilead Sciences Phase 3 2010-06-01 2015-04-22
    NCT01767987 Acute Coronary Syndrome Drug: Ranolazine|Drug: Placebo Harvey Hahn|Gilead Sciences|Kettering Health Network Phase 2 2012-11-01 2015-10-20
    NCT02147067 Microvascular Angina Drug: Ranolazine|Drug: Placebo Emory University|Gilead Sciences Phase 4 2014-09-01 2016-07-27
    NCT01558830 Chronic Stable Angina|Coronary Artery Disease|Atrial Fibrillation|Ventricular Tachycardia Drug: ranolazine|Drug: placebo Cardiovascular Consultants of Nevada|Gilead Sciences Phase 4 2012-01-01 2012-03-20
    NCT01721967 Hypertrophic Cardiomyopathy Drug: Ranolazine Duke University|Gilead Sciences Phase 4 2012-11-01 2017-01-19
    NCT03044964 Angina Drug: Ranolazine|Drug: Placebo Amit Malhotra, MD|Gilead Sciences|Stern Cardiovascular Foundation, Inc. Phase 4 2017-01-10 2017-02-03
    NCT01345188 Cardiomyopathy|Chest Pain|Dyspnea Drug: Ranexa|Drug: Placebo Midwest Cardiovascular Research Foundation|Gilead Sciences Phase 4 2011-04-01 2014-09-24
    NCT01163721 Diabetes Mellitus, Type 2 Drug: Ranolazine|Drug: Placebo Gilead Sciences Phase 2 2010-06-01 2013-07-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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