Azithromycin是抑制寄生虫类抗生素,IC50为8.4 μM。
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Saint-Criq, V., et al. 2011. Antimicrob Agents Chemother. [Epub ahead of print]. PMID: 21220528
[2] Kumar, A.P. and Park, J.H. 2011. J Chromatogr A. 1218: 1314-1317. PMID: 21256503
[3] Cigana, C., et al. 2007. Antimicrob. Agents Chemother. 51: 975-981. PMID: 17210769
[4] Mabe, S., et al. 2004. Curr. Microbiol. 49: 248-254. PMID: 15386112
分子式 C38H72N2O12 |
分子量 748.98 |
CAS号 83905-01-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 102 mg/mL |
Water <1 mg/mL |
Ethanol 100 mg/mL |
体内溶解度
NCT00879983 | Healthy Volunteers | Drug: azithromycin (Zithromax)|Drug: azithromycin (Zithromax) | Pfizer | Phase 1 | 2009-05-01 | 2010-06-11 |
NCT01109160 | Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation | Drug: Azithromycin Dihydrate | Katholieke Universiteit Leuven|Fund for Scientific Research, Flanders, Belgium | Phase 4 | 2010-04-01 | 2013-07-03 |
NCT02307825 | Chronic Rhinosinusitis|High-risk Patient | Drug: Azithromycin|Drug: Placebo | Centre hospitalier de l'Universit茅 de Montr茅al (CHUM)|Pfizer | Phase 4 | 2014-11-01 | 2016-09-26 |
NCT02911935 | Respiratory Syncytial Virus, Bronchiolitis | Drug: Oral azithromycin|Drug: Placebo | Washington University School of Medicine | Phase 2|Phase 3 | 2016-11-01 | 2016-11-05 |
NCT02575755 | Pregnancy|Infections, Plasmodia|Drug Kinetics|Clinical Efficacy | Drug: Azithromycin plus piperaquine phosphate|Drug: Sulfadoxine-pyrimethamine | Papua New Guinea Institute of Medical Research|The University of Western Australia|University of Melbourne|Malaria in Pregnancy Consortium | Phase 4 | 2012-10-01 | 2015-10-14 |
NCT02196493 | Chronic Cough | Drug: Azithromycin | University of Nottingham | Phase 3 | 2013-12-01 | 2016-02-17 |
NCT01009619 | Bronchiolitis Obliterans Syndrome|Graft Rejection|Lymphocytic Bronchiolitis|Respiratory Infection | Drug: Azithromycin|Drug: Placebo | Katholieke Universiteit Leuven|University Hospital, Gasthuisberg|Fund for Scientific Research, Flanders, Belgium | Phase 4 | 2005-09-01 | 2011-08-29 |
NCT01178762 | Chlamydial Conjunctivitis | Drug: Azithromycin | National Taiwan University Hospital | 2007-09-01 | 2010-10-05 | |
NCT01008761 | Asthma | Drug: Azithromycin|Drug: Suspension Placebo | Janielee Williamson|University of Alberta|Alberta Children's Hospital | 2010-01-01 | 2012-07-11 | |
NCT03090048 | Acne Vulgaris | Drug: Vitamin A|Drug: Azithromycin | Manchanda Medical Clinic | Early Phase 1 | 2017-04-20 | 2017-03-21 |
NCT00844207 | Malaria | Drug: Fixed combination of Azithromycin and Chloroquine|Drug: Azithromycin and Chloroquine | Pfizer | Phase 1 | 2009-02-01 | 2009-04-20 |
NCT02926326 | Interaction | Drug: BCT197|Drug: Azithromycin | Mereo BioPharma | Phase 1 | 2016-09-01 | 2016-10-21 |
NCT01783860 | Posterior Blepharitis | Drug: Azithromycin|Drug: Doxycycline | Tehran University of Medical Sciences | Phase 2 | 2013-01-01 | 2013-12-28 |
NCT02107274 | Bronchiectasis | Drug: Azithromycin|Drug: Placebo for Azithromycin | Penang Hospital, Malaysia | Phase 4 | 2011-11-01 | 2014-07-09 |
NCT01227395 | HIV Infection | Drug: Azithromycin | Pfizer|Altmarc Inc. | 2002-07-01 | 2013-04-18 | |
NCT00834132 | Healthy | Drug: Azithromycin 600 mg Tablet|Drug: Zithromax庐 600 mg Tablet | Teva Pharmaceuticals USA | Phase 1 | 2002-07-01 | 2009-09-11 |
NCT01671280 | Community-acquired Pneumonia|Pelvic Inflammatory Disease | Drug: Azithromycin IV | Pfizer | 2012-09-01 | 2017-02-09 | |
NCT00834756 | Healthy | Drug: Azithromycin 600 mg Tablet|Drug: Zithromax庐 600 mg Tablet | Teva Pharmaceuticals USA | Phase 1 | 2002-09-01 | 2009-09-11 |
NCT02803944 | Cystic Fibrosis | Drug: Azithromycin | Hospices Civils de Lyon | 2014-09-01 | 2016-06-14 | |
NCT02047981 | Childhood Mortality | Drug: Azithromycin|Drug: Placebo | University of California, San Francisco|Bill and Melinda Gates Foundation|Johns Hopkins University|London School of Hygiene and Tropical Medicine | Phase 4 | 2014-12-01 | 2016-10-12 |
NCT01154569 | Bariatric Surgery | Drug: Azithromycin | University of Alberta | 2010-06-01 | 2011-07-28 | |
NCT01778634 | Ureaplasma Infections | Drug: Azithromycin|Drug: Placebo (for azithromycin) | Rose Viscardi|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Mercy Medical Center|Johns Hopkins University|University of Virginia|University of Alabama at Birmingham|Christiana Care Health Services|University of Maryland | Phase 2 | 2013-07-01 | 2015-05-28 |
NCT01379196 | Graves Ophthalmopathy | Drug: Azithromycin | Rabin Medical Center | Phase 1|Phase 2 | 2011-05-01 | 2011-06-22 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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