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Ibuprofen

布洛芬,异丁苯丙酸

Ibuprofen 是一种抗炎类抑制剂,作用于COX-1和COX-2,IC50分别为13 μM和370 μM。

目录号
EY0333
EY0333
EY0333
纯度
99.54%
99.54%
99.54%
规格
100 mg
500 mg
1 g
原价
150
380
485
售价
150
380
485
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    最2 mM 左右

  • 动物实验

    45 mg/kg每天口服处理

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Noreen Y, et al. J Nat Prod, 1998, 61(1), 2-7.
    [2]Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
    [3] Vicky S Massicotte et. Al. Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats. Experimental Gerontology, 72, 204-217 (2015).

    分子式
    C13H18O2
    分子量
    206.28
    CAS号
    15687-27-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    40 mg/mL
    Water
    <1 mg/mL
    Ethanol
    40 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01400737 Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants Drug: ibuprofen|Drug: ibuprofen Zekai Tahir Burak Women's Health Research and Education Hospital 2011-07-01 2011-07-21
    NCT01243996 Ductus Arteriosus, Patent Drug: Ibuprofen University of Florence Phase 2|Phase 3 2008-06-01 2010-11-18
    NCT02538237 Periodontitis Drug: placebo|Drug: Ibuprofen 2% mouthwash Islamic Azad University, Tehran Phase 2|Phase 3 2013-11-01 2015-09-01
    NCT00833365 Patent Ductus Arteriosus|Prematurity Drug: Ibuprofen|Drug: Ibuprofen University of Utah|H. Lundbeck A/S 2009-01-01 2016-05-24
    NCT01334957 Pain Drug: Intravenous ibuprofen Cumberland Pharmaceuticals Phase 4 2011-06-01 2016-04-18
    NCT01261117 Patent Ductus Arteriosus Drug: oral ibuprofen Zekai Tahir Burak Women's Health Research and Education Hospital 2009-01-01 2011-08-08
    NCT01053338 Healthy Drug: Ibuprofen and Diphenhydramine Citrate Dr. Reddy's Laboratories Limited Phase 1 2008-04-01 2010-01-20
    NCT01053208 Healthy Drug: Ibuprofen and Diphenhydramine Citrate Dr. Reddy's Laboratories Limited Phase 1 2008-04-01 2010-01-20
    NCT02133326 Impacted Wisdom Teeth Drug: Caldolor|Drug: Ofirmev Tufts University School of Dental Medicine Phase 2 2014-03-01 2017-01-19
    NCT02891174 Hypertension, Pregnancy-Induced|Pre-eclampsia Drug: Ibuprofen|Drug: Acetaminophen University of Michigan Phase 4 2016-12-01 2016-12-06
    NCT01514175 Chronic Pelvic Pain Drug: IV Ibuprofen|Drug: IV Ketorolac Culpeper Surgery Center|Cumberland Pharmaceuticals Phase 4 2012-01-01 2012-05-15
    NCT01511887 Patent Ductus Arteriosus Drug: Oral Ibuprofen Hormozgan University of Medical Sciences 2011-01-01 2012-01-19
    NCT01149564 Extremely Premature Infants|PDA|Oral Ibuprofen|IV Ibuprofen Drug: iv ibuprofen|Drug: oral ibuprofen China Medical University Hospital Phase 1|Phase 2 2009-12-01 2010-06-22
    NCT01334944 Pain|Fever Drug: Intravenous ibuprofen Cumberland Pharmaceuticals Phase 4 2011-06-01 2016-07-28
    NCT02152163 Pain Drug: IV Ibuprofen|Drug: placebo Delray Medical Center Phase 4 2012-10-01 2015-10-12
    NCT00921830 Healthy Drug: ibuprofen Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2004-04-01 2011-10-04
    NCT01149941 Healthy Drug: Ibuprofen Dr. Reddy's Laboratories Limited Phase 1 2002-11-01 2010-06-25
    NCT02096913 Spinal Cord Injury Drug: Dolormin庐 extra (Ibuprofen)|Drug: Dolormin庐 extra (Ibuprofen) Jan M. Schwab, MD, PhD|Else Kr枚ner Fresenius Foundation|Charite University, Berlin, Germany Phase 1 2013-06-01 2017-03-21
    NCT01149954 Healthy Drug: Ibuprofen Dr. Reddy's Laboratories Limited Phase 1 2003-01-01 2010-06-28
    NCT01536158 Patent Ductus Arteriosus Drug: Oral paracetamol|Drug: Oral ibuprofen Zekai Tahir Burak Women's Health Research and Education Hospital Phase 4 2012-02-01 2012-12-24

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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