Ibuprofen 是一种抗炎类抑制剂,作用于COX-1和COX-2,IC50分别为13 μM和370 μM。
Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
最2 mM 左右
45 mg/kg每天口服处理
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Noreen Y, et al. J Nat Prod, 1998, 61(1), 2-7.
[2]Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
[3] Vicky S Massicotte et. Al. Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats. Experimental Gerontology, 72, 204-217 (2015).
分子式 C13H18O2 |
分子量 206.28 |
CAS号 15687-27-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 40 mg/mL |
Water <1 mg/mL |
Ethanol 40 mg/mL |
体内溶解度
NCT01400737 | Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants | Drug: ibuprofen|Drug: ibuprofen | Zekai Tahir Burak Women's Health Research and Education Hospital | 2011-07-01 | 2011-07-21 | |
NCT01243996 | Ductus Arteriosus, Patent | Drug: Ibuprofen | University of Florence | Phase 2|Phase 3 | 2008-06-01 | 2010-11-18 |
NCT02538237 | Periodontitis | Drug: placebo|Drug: Ibuprofen 2% mouthwash | Islamic Azad University, Tehran | Phase 2|Phase 3 | 2013-11-01 | 2015-09-01 |
NCT00833365 | Patent Ductus Arteriosus|Prematurity | Drug: Ibuprofen|Drug: Ibuprofen | University of Utah|H. Lundbeck A/S | 2009-01-01 | 2016-05-24 | |
NCT01334957 | Pain | Drug: Intravenous ibuprofen | Cumberland Pharmaceuticals | Phase 4 | 2011-06-01 | 2016-04-18 |
NCT01261117 | Patent Ductus Arteriosus | Drug: oral ibuprofen | Zekai Tahir Burak Women's Health Research and Education Hospital | 2009-01-01 | 2011-08-08 | |
NCT01053338 | Healthy | Drug: Ibuprofen and Diphenhydramine Citrate | Dr. Reddy's Laboratories Limited | Phase 1 | 2008-04-01 | 2010-01-20 |
NCT01053208 | Healthy | Drug: Ibuprofen and Diphenhydramine Citrate | Dr. Reddy's Laboratories Limited | Phase 1 | 2008-04-01 | 2010-01-20 |
NCT02133326 | Impacted Wisdom Teeth | Drug: Caldolor|Drug: Ofirmev | Tufts University School of Dental Medicine | Phase 2 | 2014-03-01 | 2017-01-19 |
NCT02891174 | Hypertension, Pregnancy-Induced|Pre-eclampsia | Drug: Ibuprofen|Drug: Acetaminophen | University of Michigan | Phase 4 | 2016-12-01 | 2016-12-06 |
NCT01514175 | Chronic Pelvic Pain | Drug: IV Ibuprofen|Drug: IV Ketorolac | Culpeper Surgery Center|Cumberland Pharmaceuticals | Phase 4 | 2012-01-01 | 2012-05-15 |
NCT01511887 | Patent Ductus Arteriosus | Drug: Oral Ibuprofen | Hormozgan University of Medical Sciences | 2011-01-01 | 2012-01-19 | |
NCT01149564 | Extremely Premature Infants|PDA|Oral Ibuprofen|IV Ibuprofen | Drug: iv ibuprofen|Drug: oral ibuprofen | China Medical University Hospital | Phase 1|Phase 2 | 2009-12-01 | 2010-06-22 |
NCT01334944 | Pain|Fever | Drug: Intravenous ibuprofen | Cumberland Pharmaceuticals | Phase 4 | 2011-06-01 | 2016-07-28 |
NCT02152163 | Pain | Drug: IV Ibuprofen|Drug: placebo | Delray Medical Center | Phase 4 | 2012-10-01 | 2015-10-12 |
NCT00921830 | Healthy | Drug: ibuprofen | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 1 | 2004-04-01 | 2011-10-04 |
NCT01149941 | Healthy | Drug: Ibuprofen | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-11-01 | 2010-06-25 |
NCT02096913 | Spinal Cord Injury | Drug: Dolormin庐 extra (Ibuprofen)|Drug: Dolormin庐 extra (Ibuprofen) | Jan M. Schwab, MD, PhD|Else Kr枚ner Fresenius Foundation|Charite University, Berlin, Germany | Phase 1 | 2013-06-01 | 2017-03-21 |
NCT01149954 | Healthy | Drug: Ibuprofen | Dr. Reddy's Laboratories Limited | Phase 1 | 2003-01-01 | 2010-06-28 |
NCT01536158 | Patent Ductus Arteriosus | Drug: Oral paracetamol|Drug: Oral ibuprofen | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 4 | 2012-02-01 | 2012-12-24 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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