Home > Cytochromes P450 (CYPs) & Dehydrogenase & Dopamine β-hydroxylase & DNA Methyltransferase & > Disulfiram

Disulfiram

双硫仑,NSC 190940,NSC-190940,NSC190940

Disulfiram是氨基甲酸酯衍生物，可作用于多巴胺-β-羟化酶。

目录号
EY0332
EY0332
EY0332
纯度
99.53%
99.53%
99.53%
规格
10 mg
50 mg
100 mg
原价
112.00
268.00
386.00
售价
112.00
268.00
386.00
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Chen D, et al. Cancer Res, 2006, 66(21), 10425-10433.
    [2] Helen L Wiggins et. Al. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology, 93(3), 332-342 (2015).
    [3] Ruijin Zheng et. Al. Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicology and Applied Pharmacology, 279(1), 43-52 (2014).

    分子式
    C10H20N2S4    		 分子量
    296.54    		 CAS号
    97-77-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    5 mg/mL    		 Ethanol
    72 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02735577 Alcohol Use Disorder Drug: Disulfiram New York State Psychiatric Institute Phase 4 2016-03-01 2016-09-20
    NCT00731133 Methamphetamine Dependence Drug: Disulfiram University of Arkansas Phase 1|Phase 2 2008-08-01 2012-01-20
    NCT00149630 Cocaine Dependence|Opioid Dependence Drug: Disulfiram|Drug: Methadone|Behavioral: CBT|Other: Lactose Baylor College of Medicine|National Institute on Drug Abuse (NIDA)|Yale University Phase 2 2005-01-01 2017-02-04
    NCT01944371 HIV|Human Immunodeficiency Virus Drug: Disulfiram University of California, San Francisco|Monash University|amfAR, The Foundation for AIDS Research|National Institute of Allergy and Infectious Diseases (NIAID) Phase 1|Phase 2 2013-08-01 2014-10-27
    NCT00878306 HIV Infections|Drug Abuse Drug: Disulfiram|Drug: Disulfiram + Efavirenz|Drug: Disulfiram + Atazanavir|Drug: Disulfiram + Ritonavir University of California, San Francisco|National Institute on Drug Abuse (NIDA) Phase 1 2008-11-01 2014-05-04
    NCT00218608 Cocaine-Related Disorders|Opioid-Related Disorders Drug: Disulfiram University of Arkansas|Yale University Phase 2 2001-04-01 2012-01-26
    NCT00571116 Metastatic Melanoma Drug: Disulfiram|Drug: Arsenic trioxide University of California, Irvine Phase 1|Phase 2 2006-09-01 2016-12-31
    NCT01286259 HIV-1 Infection Drug: Disulfiram University of California, San Francisco|Johns Hopkins University 2011-01-01 2014-10-28
    NCT00742911 Cancer Drug: Disulfiram|Drug: Copper Gluconate University of Utah Phase 1 2008-07-01 2014-10-29
    NCT00721526 Alcohol Dependence|Anxiety Disorder Drug: disulfiram plus lorazepam University of New Mexico|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 4 2009-08-01 2013-01-28
    NCT00395850 Cocaine Dependence Drug: Disulfiram University of Arkansas|National Institute on Drug Abuse (NIDA) Phase 2 2007-04-01 2013-09-06
    NCT00913484 Cocaine Dependence|Opioid Dependency Drug: Disulfiram|Drug: Placebo Yale University|National Institute on Drug Abuse (NIDA) Phase 2 2000-10-01 2009-06-03
    NCT00256230 Stage IV Melanoma Drug: Disulfiram (DSF) John P. Fruehauf|University of California, Irvine Phase 1|Phase 2 2002-01-01 2016-12-06
    NCT01907165 Glioblastoma Drug: Temozolomide|Drug: Disulfiram|Dietary Supplement: Copper gluconate Washington University School of Medicine Early Phase 1 2013-10-10 2017-03-14
    NCT00580827 Cocaine-Related Disorder|Opiate Dependence Drug: Placebo|Drug: Disulfiram|Drug: Disulfiram|Drug: Disulfiram Yale University|National Institute on Drug Abuse (NIDA) 2003-09-01 2007-12-25
    NCT01777919 Glioblastoma Multiforme Drug: Temozolomide|Drug: Disulfiram|Drug: Copper Olympion Medical Center|University of Ioannina|University of Eastern Finland|University of Ulm Phase 2 2017-01-01 2016-10-14
    NCT02101008 Melanoma Drug: disulfiram and chelated zinc University of Utah Phase 2 2010-03-01 2015-12-21
    NCT00002065 HIV Infections Drug: Disulfiram St. Vincent's Medical Center|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00000278 Alcohol-Related Disorders|Cocaine-Related Disorders Drug: Disulfiram Yale University|National Institute on Drug Abuse (NIDA)|VA Connecticut Healthcare System Phase 2 1994-09-01 2013-07-24
    NCT03034135 Recurrent Glioblastoma Drug: Disulfiram/Copper Cantex Pharmaceuticals Phase 2 2017-03-09 2017-03-10

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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