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Ciclopirox ethanolamine

环吡司胺

Ciclopirox olamine是一种合成的抗真菌剂,用于浅部真菌病的局部皮肤病治疗, 针对花斑癣最有效。

目录号
EY0329
EY0329
EY0329
纯度
99.16%
99.16%
99.16%
规格
50 mg
100 mg
500 mg
原价
380
520
1480
售价
380
520
1480
库存
现货
现货
现货
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  • 生物活性

    Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    10 μg/mL

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Niewerth M, et al. Antimicrob Agents Chemother, 2003, 47(6), 1805-1817.
    [2] Ken Fujimura et. Al. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Research, 74(22), 6671-6681 (2014)
    [3] Siyuan Song et. Al. Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. Cancer Research, 71(24), 7628-7639 (2011).

    分子式
    C14H24N2O3    		 分子量
    268.35    		 CAS号
    41621-49-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    6 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    30 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00990587 Hematologic Malignancy|Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Myelodysplasia|Acute Myeloid Leukemia|Chronic Myelogenous Leukemia|Hodgkin's Disease Drug: Ciclopirox Olamine University Health Network, Toronto|The Leukemia and Lymphoma Society Phase 1 2009-10-01 2015-06-19
    NCT01646580 Dermatomycoses Drug: ciclopirox Ferrer Internacional S.A. Phase 4 2008-10-01 2012-07-19
    NCT00802672 Tinea Pedis Drug: Ciclopirox Olamine Cream|Drug: Loprox Cream 0.77%|Drug: Placebo Perrigo Company Phase 3 2003-12-01 2013-01-17
    NCT02679911 Foot Dermatoses Drug: Loceryl Nail Lacquer|Drug: Ciclopirox Nail Lacquer Galderma Phase 4 2015-09-01 2016-07-26
    NCT01014637 Onychomycosis Drug: Amorolfine (Antifungal)|Drug: RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal) Pierre Fabre Dermo Cosmetique|Quanta Medical Phase 4 2009-08-01 2009-11-16
    NCT00804193 Tinea Pedis Drug: Ciclopirox Olamine Topical Suspension|Drug: Ciclopirox Topical Suspension 0.77%-Reference Product|Drug: Ciclopirox Olamine Topical Suspension-Placebo Perrigo Company 2004-06-01 2014-01-09
    NCT01419847 Onychomycosis Drug: Ciclopirox|Drug: Placebo Rady Children's Hospital, San Diego Phase 4 2002-03-01 2011-08-17
    NCT00382330 Vulvar Cancer Drug: Ciclopirox University of Medicine and Dentistry of New Jersey|Rutgers, The State University of New Jersey null 2013-09-05
    NCT00127868 Tinea Capitis Drug: oral griseofulvin, selenium sulfide shampoo 1%, ciclopirox shampoo , ketoconazole shampoo 2%, baby shampoo Chen, Catherine, M.D.|Williams, Judith V., M.D.|Hubbard, Thomas W., M.D.|Eastern Virginia Medical School 2005-03-01 2008-07-07
    NCT02961634 Onychomycosis Device: Nailner 2 in 1|Drug: Ciclopirox 8% MIP Brasil Ind煤stria e Com茅rcio de Produtos Farmac锚uticos LTDA|Buranello e Rodrigues Consultoria em Desenvolvimento Farmac锚utico Ltda ME Phase 3 2016-11-01 2016-11-16
    NCT02644551 Onychomycosis Drug: CELEXT07|Drug: Penlac|Other: vehicle solution 9305-9954 Quebec Inc Phase 2 2016-08-01 2016-08-05
    NCT01139749 Seborrhea|Seborrheic Dermatitis|Quality of Life Drug: oral isotretinoin|Drug: salicylic acid and ciclopirox olamine Federal University of S茫o Paulo Phase 4 2011-10-01 2011-10-09
    NCT02866032 Distal Subungual Onychomycosis Drug: MOB015B|Drug: Ciclopirox 80 mg/g Moberg Pharma AB Phase 3 2016-09-01 2016-10-18
    NCT02004860 Severe Seborrheic Dermatitis Drug: Protopic (R)|Drug: Mycoster (R) University Hospital, Rouen Phase 3 2014-01-01 2016-12-06

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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