Venlafaxine hydrochloride 是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。
Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ball SE, et al. Br J Clin Pharmacol, 1997, 43(6), 619-626.
[2] Bymaster, F.P., et al. 2001. Neuropsychopharmacology. 25: 871-880.
[3] Blier, P., et al. 2007. Int. J. Neuropsychopharmacol. 10: 41-50.
[4] Berrocoso, E. and Mico, J.A. 2007. J. Pharmacol. Exp. Ther. 322: 101-107.
分子式 C17H28ClNO2 |
分子量 313.86 |
CAS号 99300-78-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mM |
Water >25 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT01867255 | Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass | Drug: venlafaxine ER (extended-release) 75 mg | Mayo Clinic | Phase 1 | 2013-10-01 | 2015-12-21 |
NCT02005107 | Roux en Y Gastric Bypass|Sleeve Gastrectomy | Drug: Venlafaxine IR and Venlafaxine XR | North Dakota State University|Neuropsychiatric Research Institute, Fargo, North Dakota | Phase 4 | 2013-12-01 | 2016-04-04 |
NCT01716377 | Neck Pain | Drug: Venlafaxine | Rhode Island Hospital|Mayday Fund|University of North Carolina|University of Cincinnati | Phase 2 | 2012-10-01 | 2015-10-30 |
NCT00198250 | Breast Cancer | Drug: venlafaxine | Indiana University School of Medicine|Vanderbilt University|Indiana University | Phase 2 | 2000-05-01 | 2008-11-13 |
NCT01282814 | Healthy | Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR | Teva Pharmaceuticals USA | Phase 1 | 2003-02-01 | 2011-02-11 |
NCT01282801 | Healthy | Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR | Teva Pharmaceuticals USA | Phase 1 | 2002-09-01 | 2011-02-11 |
NCT00131456 | Depression|Marijuana Abuse | Drug: Venlafaxine|Drug: Placebo | New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) | Phase 2 | 2004-03-01 | 2016-04-06 |
NCT01824433 | Major Depression | Drug: venlafaxine|Drug: fluoxetine | Capital Medical University | Phase 4 | 2013-03-01 | 2016-08-01 |
NCT02958527 | Depression/Depressed State | Drug: venlafaxine | Pfizer | 2016-10-01 | 2017-02-10 | |
NCT01512459 | Healthy | Drug: Venlafaxine | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-05-01 | 2012-01-18 |
NCT00871364 | Healthy | Drug: VENLAFAXINE TABLETS 50 mg , single dose|Drug: Effexor庐 Tablets equivalent to 50 mg venlafaxine | Actavis Inc. | Phase 1 | 2006-04-01 | 2010-08-13 |
NCT02051413 | Major Depressive Disorder|Major Depressive Episode | Drug: Venlafaxine extended release | Institut National de la Sant茅 Et de la Recherche M茅dicale, France | Phase 4 | 2014-02-01 | 2016-02-24 |
NCT02350985 | Vestibular Migraine | Drug: Propranolol|Drug: Venlafaxine | Haseki Training and Research Hospital | Phase 4 | 2014-01-01 | 2015-01-29 |
NCT01609348 | Alzheimer's Disease|Depression | Drug: Placebo|Drug: Venlafaxine | Johns Hopkins University | 2012-04-01 | 2017-03-03 | |
NCT01533753 | Prostate Cancer | Drug: Gabapentin|Drug: Venlafaxine | University of Wisconsin, Madison | Phase 2 | 2012-02-01 | 2014-09-10 |
NCT00834964 | Healthy | Drug: Venlafaxine 25 mg Tablets|Drug: Effexor庐 25 mg Tablets | Teva Pharmaceuticals USA | Phase 1 | 2002-12-01 | 2009-09-11 |
NCT00834249 | Healthy | Drug: Venlafaxine 25 mg Tablets|Drug: Effexor庐 25 mg Tablets | Teva Pharmaceuticals USA | Phase 1 | 2002-12-01 | 2009-09-11 |
NCT01235338 | Healthy | Drug: LDX + Venlafaxine XR|Drug: Venlafaxine XR + LDX | Shire | Phase 1 | 2010-11-01 | 2013-03-27 |
NCT01557712 | Major Depressive Disorder | Drug: ketamine venlafaxine|Drug: Venlafaxine | University Hospital, Grenoble | Phase 3 | 2012-03-01 | 2017-02-23 |
NCT01569685 | Post Traumatic Stress Disorder|Depression | Drug: Venlafaxine|Drug: Sertraline | Charlotte Sonne|Psychiatric Center Ballerup | Phase 4 | 2012-04-01 | 2015-03-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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