Venlafaxine

文拉法辛,维拉法司,顽发克星,Wy 45030 hydrochloride,Effexor hydrochloride,Wy45030,Wy-45030,

Venlafaxine hydrochloride 是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。

目录号
EY0307
EY0307
EY0307
EY0307
EY0307
纯度
99.35%
99.35%
99.35%
99.35%
99.35%
规格
2 mg
5 mg
10 mg
25 mg
50 mg
原价
150.00
240
390
720
1100
售价
150.00
240
390
720
1100
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Ball SE, et al. Br J Clin Pharmacol, 1997, 43(6), 619-626.
    [2] Bymaster, F.P., et al. 2001. Neuropsychopharmacology. 25: 871-880.
    [3] Blier, P., et al. 2007. Int. J. Neuropsychopharmacol. 10: 41-50.
    [4] Berrocoso, E. and Mico, J.A. 2007. J. Pharmacol. Exp. Ther. 322: 101-107.

    分子式
    C17H28ClNO2
    分子量
    313.86
    CAS号
    99300-78-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mM
    Water
    >25 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01867255 Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass Drug: venlafaxine ER (extended-release) 75 mg Mayo Clinic Phase 1 2013-10-01 2015-12-21
    NCT02005107 Roux en Y Gastric Bypass|Sleeve Gastrectomy Drug: Venlafaxine IR and Venlafaxine XR North Dakota State University|Neuropsychiatric Research Institute, Fargo, North Dakota Phase 4 2013-12-01 2016-04-04
    NCT01716377 Neck Pain Drug: Venlafaxine Rhode Island Hospital|Mayday Fund|University of North Carolina|University of Cincinnati Phase 2 2012-10-01 2015-10-30
    NCT00198250 Breast Cancer Drug: venlafaxine Indiana University School of Medicine|Vanderbilt University|Indiana University Phase 2 2000-05-01 2008-11-13
    NCT01282814 Healthy Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR Teva Pharmaceuticals USA Phase 1 2003-02-01 2011-02-11
    NCT01282801 Healthy Drug: Venlafaxine Hydrochloride|Drug: Effexor庐 XR Teva Pharmaceuticals USA Phase 1 2002-09-01 2011-02-11
    NCT00131456 Depression|Marijuana Abuse Drug: Venlafaxine|Drug: Placebo New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) Phase 2 2004-03-01 2016-04-06
    NCT01824433 Major Depression Drug: venlafaxine|Drug: fluoxetine Capital Medical University Phase 4 2013-03-01 2016-08-01
    NCT02958527 Depression/Depressed State Drug: venlafaxine Pfizer 2016-10-01 2017-02-10
    NCT01512459 Healthy Drug: Venlafaxine Dr. Reddy's Laboratories Limited Phase 1 2006-05-01 2012-01-18
    NCT00871364 Healthy Drug: VENLAFAXINE TABLETS 50 mg , single dose|Drug: Effexor庐 Tablets equivalent to 50 mg venlafaxine Actavis Inc. Phase 1 2006-04-01 2010-08-13
    NCT02051413 Major Depressive Disorder|Major Depressive Episode Drug: Venlafaxine extended release Institut National de la Sant茅 Et de la Recherche M茅dicale, France Phase 4 2014-02-01 2016-02-24
    NCT02350985 Vestibular Migraine Drug: Propranolol|Drug: Venlafaxine Haseki Training and Research Hospital Phase 4 2014-01-01 2015-01-29
    NCT01609348 Alzheimer's Disease|Depression Drug: Placebo|Drug: Venlafaxine Johns Hopkins University 2012-04-01 2017-03-03
    NCT01533753 Prostate Cancer Drug: Gabapentin|Drug: Venlafaxine University of Wisconsin, Madison Phase 2 2012-02-01 2014-09-10
    NCT00834964 Healthy Drug: Venlafaxine 25 mg Tablets|Drug: Effexor庐 25 mg Tablets Teva Pharmaceuticals USA Phase 1 2002-12-01 2009-09-11
    NCT00834249 Healthy Drug: Venlafaxine 25 mg Tablets|Drug: Effexor庐 25 mg Tablets Teva Pharmaceuticals USA Phase 1 2002-12-01 2009-09-11
    NCT01235338 Healthy Drug: LDX + Venlafaxine XR|Drug: Venlafaxine XR + LDX Shire Phase 1 2010-11-01 2013-03-27
    NCT01557712 Major Depressive Disorder Drug: ketamine venlafaxine|Drug: Venlafaxine University Hospital, Grenoble Phase 3 2012-03-01 2017-02-23
    NCT01569685 Post Traumatic Stress Disorder|Depression Drug: Venlafaxine|Drug: Sertraline Charlotte Sonne|Psychiatric Center Ballerup Phase 4 2012-04-01 2015-03-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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