Home > HIV & NRTIs & > Stavudine

Stavudine

司他夫定,D4T,D4T,BMY-27857,Sanilvudine,NSC 163661,NSC-163661,NSC163661,BMY 27857

Stavudine是核苷类似物，能抑制HIV逆转录酶。

目录号
EY0306
EY0306
纯度
99.58%
99.58%
规格
100 mg
500 mg
原价
420
915
售价
420
915
库存
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Caron M, et al. AIDS, 2004, 18(16), 2127-2136.
    [2] John C Martin et. al Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides. Antiviral Research, 85(1), 34-38 (2010).
    [3] William P Gallagher et. Al. A Claisen approach to 4'-Ed4T. Organic Letters, 17(1), 14-17 (2015).

    分子式
    C10H12N2O4    		 分子量
    224.21    		 CAS号
    3056-17-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    43 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    15 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02670772 Acquired Immune Deficiency Syndrome|Human Immunodeficiency Virus Drug: Stavudine|Drug: Tenofovir Disoproxil Fumarate Willem Daniel Francois Venter|Bill and Melinda Gates Foundation|University of Witwatersrand, South Africa Phase 3 2012-07-01 2016-01-28
    NCT00235222 HIV Drug: stavudine Groupe Hospitalier Pitie-Salpetriere|Bristol-Myers Squibb Phase 4 2004-06-01 2005-10-24
    NCT00002349 HIV Infections Drug: Stavudine Bristol-Myers Squibb 1995-01-01 2011-04-13
    NCT00002308 HIV Infections Drug: Stavudine Bristol-Myers Squibb null 2011-08-04
    NCT00002246 AIDS Dementia Complex|HIV Infections Drug: Stavudine Bristol-Myers Squibb Phase 3 1997-10-01 2011-04-28
    NCT00002307 HIV Infections Drug: Stavudine|Drug: Zidovudine Bristol-Myers Squibb null 2011-08-04
    NCT00312091 HIV Infections Drug: Lamivudine, nevirapine, and stavudine fixed-dose tablet|Drug: Lamivudine|Drug: Nevirapine|Drug: Stavudine National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|International Maternal Pediatric Adolescent AIDS Clinical Trials Group Phase 1|Phase 2 2006-12-01 2012-09-10
    NCT00000851 HIV Infections Drug: Stavudine|Drug: Didanosine National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 null 2012-05-01
    NCT00002207 HIV Infections Drug: Stavudine|Drug: Didanosine Bristol-Myers Squibb 2004-02-01 2011-04-13
    NCT00528957 HIV Infections Drug: Tenofovir DF|Drug: Zidovudine|Drug: Stavudine Gilead Sciences Phase 3 2006-12-01 2016-12-08
    NCT00000789 HIV Infections Drug: Stavudine|Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome|Bristol-Myers Squibb Phase 2 null 2012-03-30
    NCT01601899 Mitochondrial Toxicity|Metabolic Complications Drug: Stavudine|Drug: Stavudine|Drug: Tenofovir University of Witwatersrand, South Africa Phase 4 2008-10-01 2012-05-16
    NCT00002354 HIV Infections Drug: Indinavir sulfate|Drug: Stavudine Merck Sharp & Dohme Corp.|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00116298 HIV Infections|AIDS Drug: stavudine, efavirenz, lamivudine Bristol-Myers Squibb Phase 3 2001-01-01 2011-04-08
    NCT00455585 HIV Infections Drug: nevirapine, stavudine, lamivudine Makerere University|Department of Foreign Affairs, Ireland Phase 4 2007-01-01 2008-02-07
    NCT01025830 HIV/AIDS Drug: Triomune|Drug: Zerit/Epivir/Viramune Makerere University|University of California, San Francisco Phase 4 2006-02-01 2009-12-31
    NCT00002225 HIV Infections Drug: Efavirenz|Drug: Stavudine|Drug: Didanosine Dupont Merck|NIH AIDS Clinical Trials Information Service Phase 2 null 2005-06-23
    NCT00002381 HIV Infections Drug: Nelfinavir mesylate|Drug: Nevirapine|Drug: Stavudine Boehringer Ingelheim|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT00005918 HIV Infections Drug: Efavirenz|Drug: Lamivudine|Drug: Stavudine Bristol-Myers Squibb Phase 3 2000-06-01 2011-04-28
    NCT00158821 HIV Infections Drug: Viread (tenofovir disoproxil fumarate)|Drug: Sustiva (Efavirenz)|Drug: Epivir (Lamivudine)|Drug: Zerit (Stavudine) Placebo Gilead Sciences Phase 3 2000-03-01 2013-06-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：