Ascorbic acid是天然有机物,有抗氧化活性。
Vitamin C is a water-soluble vitamin indicated for the prevention and treatment of scurvy.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Bram S, et al. Nature, 1980, 284(5757), 629-631.
[2] Ran Kang et. Al. Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. Stem Cell Research & Therapy, 6(1), 144 (2015).
[3]Qingjie Wang et. Al. Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration. American Journal of Physiology - Heart and Circulatory Physiology, 309(11), H1894-H1903 (2015).
分子式 C6H8O6 |
分子量 176.12 |
CAS号 50-81-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 20 mg/mL |
Water 10 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT02606773 | Vitamin C Deficiency | Drug: Ascorbic Acid | Semmelweis University|Novonex Pharma Kft | Phase 1 | 2015-06-01 | 2015-11-16 |
NCT02083575 | Vitamin c|Thalassemia Major|Iron Chelation | Drug: Vitamin C, Defriprone, deferisarox|Drug: deferiprone , deferesarox | Ain Shams University | Phase 2|Phase 3 | 2014-04-01 | 2014-03-07 |
NCT01723696 | Pulmonary Function; Newborn, Abnormal|Infant Wheeze|In-utero Nicotine|Second Hand Smoke | Dietary Supplement: Vitamin C +prenatal vitamin|Dietary Supplement: Placebo tablet+prenatal vitamin | Oregon Health and Science University|National Heart, Lung, and Blood Institute (NHLBI)|Office of Dietary Supplements (ODS) | Phase 2|Phase 3 | 2012-12-01 | 2016-09-26 |
NCT01356433 | Uremia|Inflammation | Drug: oral vitamin C|Drug: oral vitamin C | Peking University First Hospital | Phase 4 | 2011-08-01 | 2012-09-19 |
NCT01743742 | Birth Asphyxia | Drug: Vitamin E, Vitamin C | Sir Takhtasinhji General Hospital | Phase 4 | 2013-05-01 | 2014-08-22 |
NCT02780505 | Anemia | Drug: vitamin c|Drug: placebo | Shiraz University of Medical Sciences | Phase 4 | 2011-11-01 | 2016-05-19 |
NCT00350077 | Burns | Drug: Intravenous Vitamin C|Drug: Vitamin C | United States Army Institute of Surgical Research|University of Miami | 2006-07-01 | 2011-12-19 | |
NCT01369043 | Exercise and Non-exercise Effect Upon Vitamins E and C | Dietary Supplement: Vitamin E and Vitamin C | USDA Grand Forks Human Nutrition Research Center | 2011-05-01 | 2015-03-06 | |
NCT01413360 | Chronic Hepatitis|Chronic Hepatitis C|Chronic Alcoholic Hepatitis | Drug: High dose vitamin C | Seoul National University Hospital | Phase 4 | 2011-08-01 | 2016-06-06 |
NCT02455180 | Multiple Organ Failure|Sepsis|Systemic Inflammatory Response Syndrome|Trauma | Drug: Ascorbic Acid | VU University Medical Center | Phase 4 | 2015-03-01 | 2016-05-09 |
NCT02369822 | Idiopathic Epilepsy | Dietary Supplement: Vitamin C | Ain Shams University | Phase 2 | 2015-02-01 | 2015-02-23 |
NCT00534014 | Atherosclerosis|Type 2 Diabetes | Dietary Supplement: Vitamin C | University of New Mexico|American Diabetes Association | 2006-01-01 | 2008-03-31 | |
NCT02762331 | Disorder of Vitamin C|Atrial Fibrillation|Complications Due to Coronary Artery Bypass Graft|Heart Valve Disease | Drug: Ascorbic Acid|Drug: Placebo | Virginia Commonwealth University | Phase 1 | 2017-01-01 | 2017-03-02 |
NCT01587261 | Severe Thermal Injury, Greater Than 20% TBSA | Drug: Vitamin C|Drug: Placebo | University of Texas Southwestern Medical Center | Phase 2 | 2017-06-01 | 2016-01-12 |
NCT01090895 | Angina Pectoris | Drug: Vitamin C|Drug: Placebo | University of Roma La Sapienza | Phase 4 | 2010-03-01 | 2016-03-08 |
NCT01338129 | Ankle Fracture | Dietary Supplement: vitamin c|Drug: placebo | Rabin Medical Center | 2011-04-01 | 2011-04-18 | |
NCT00920413 | Anemia|Peritoneal Dialysis | Dietary Supplement: Vitamin C|Dietary Supplement: placebo | St. Michael's Hospital, Toronto | Phase 3 | 2002-03-01 | 2009-06-12 |
NCT00869427 | Urinary Tract Infection|Spinal Cord Injury | Drug: vitamin C | Sunnaas Rehabilitation Hospital|Dentsply Sirona Implants | Phase 4 | 2009-03-01 | 2010-07-02 |
NCT01434121 | Sepsis|Septic Shock|Hypotension|Acute Lung Injury | Drug: Ascorbic Acid|Drug: Placebo | Virginia Commonwealth University | Phase 1|Phase 2 | 2010-05-01 | 2014-05-30 |
NCT01319734 | Type 2 Diabetes Mellitus | Dietary Supplement: Vitamin C|Drug: glyburide | Al-Neelain University | Phase 1 | 2011-02-01 | 2013-09-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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