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Esomeprazole Magnesium

埃索美拉唑镁

Esomeprazole Magnesium是一种质子泵抑制剂，减少胃酸分泌。

目录号
EY0302
EY0302
EY0302
纯度
99.42%
99.42%
99.42%
规格
50 mg
100 mg
500 mg
原价
450
990
2900
售价
450
990
2900
库存
现货
现货
现货
订购
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  • 生物活性

    Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Lu J,et al. Novel naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2016 Sep;42(9):1495-503. doi: 10.3109/03639045.2016.1151029. Epub 2016 Feb 29.
    [2] Skieneh J,et al. Crystallization of Esomeprazole Magnesium Water/Butanol Solvate. Molecules. 2016 Apr 23;21(4):544. doi: 10.3390/molecules21040544.

    分子式
    2(C17H18N3O3S)2.Mg    		 分子量
    713.12    		 CAS号
    161973-10-0     		储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    140 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    140 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00637845 Heartburn|Gastroesophageal Reflux Disease Drug: Esomeprazole Magnesium|Drug: Lansoprazole AstraZeneca Phase 4 2002-06-01 2011-01-20
    NCT00206440 Nausea Drug: esomeprazole|Drug: Esomeprazole (aka Nexium)|Other: Placebo Baylor Breast Care Center|AstraZeneca Phase 3 2005-08-01 2012-04-27
    NCT00687245 Endoscopically-Proven GERD|Reflux Drug: esomeprazole magnesium AstraZeneca Phase 1 2006-08-01 2008-06-10
    NCT01135472 Healthy Drug: Esomeprazole Magnesium City of Hope Medical Center Phase 1 2010-03-01 2012-12-14
    NCT00625495 Gastroesophageal Reflux Disease Drug: Esomeprazole|Drug: Esomeprazole AstraZeneca Phase 4 2002-09-01 2011-01-21
    NCT03083639 Healthy Participants Drug: Esomeprazole Capsule|Drug: Esomeprazole Tablet Takeda Phase 1 2017-03-01 2017-03-14
    NCT00641602 Erosive Esophagitis Drug: Esomeprazole|Drug: Lansoprazole AstraZeneca Phase 4 2002-12-01 2009-03-25
    NCT01089959 Gastroesophageal Reflux Disease Drug: Esomeprazole|Drug: esomeprazole Southern Arizona VA Health Care System Phase 2|Phase 3 2010-03-01 2010-08-18
    NCT00626262 Gastroesophageal Reflux Disease Drug: Esomeprazole AstraZeneca Phase 4 2002-07-01 2011-01-21
    NCT00626535 Symptomatic Gastroesophageal Reflux Disease (sGERD) Drug: Esomeprazole|Drug: Matching placebo AstraZeneca Phase 3 2003-03-01 2009-03-11
    NCT02659683 Healthy Subjects Drug: Nexium 40 mg DR Capsules of AstraZeneca LP, USA|Drug: Torrent's Esomeprazole Magnesium DR Capsules 40 mg Torrent Pharmaceuticals Limited Phase 1 2011-05-01 2016-02-02
    NCT01275937 Upper Gastrointestinal Bleeding Drug: Esomeprazole|Drug: esomeprazole Taipei Medical University Phase 4 2011-08-01 2011-08-11
    NCT02670642 Gastroesophageal Reflux Drug: Esomeprazole AstraZeneca Phase 3 2001-08-01 2016-01-28
    NCT00629564 GERD Drug: Esomeprazole|Drug: Esomeprazole AstraZeneca Phase 4 2002-09-01 2011-01-24
    NCT02680132 Healthy Drug: Nexium 40 mg DR Capsules of AstraZeneca LP, USA|Drug: Torrent's Esomeprazole Magnesium DR Capsules 40 mg Torrent Pharmaceuticals Limited Phase 1 2011-05-01 2016-02-08
    NCT00637559 Barrett's Esophagus Drug: Esomeprazole Magnesium AstraZeneca Phase 4 2002-03-01 2011-01-24
    NCT01199328 Healthy Volunteers Drug: Aspirin|Drug: Esomeprazole AstraZeneca Phase 1 2010-09-01 2010-11-18
    NCT00786695 Gastroesophageal Reflux Disease Drug: esomeprazole|Drug: Placebo National University Hospital, Singapore 2006-05-01 2011-03-02
    NCT00206180 Erosive Esophagitis|Reflux Esophagitis|Gastroesophageal Reflux Disease Drug: esomeprazole magnesium (oral medication) AstraZeneca Phase 4 2004-06-01 2009-03-25
    NCT00644735 Erosive Esophagitis Drug: Esomeprazole|Drug: Lansoprazole AstraZeneca Phase 4 2002-12-01 2009-03-25

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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