Cholesterol是哺乳动物中主要的甾体类化合物,在基本的细胞生命活动中起到重要作用。
Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Alomrani AH,et al. Alomrani, AH. et al. 2016. Flexosomes for transdermal delivery of meloxicam: characterization and antiinflammatory activity. Artif Cells Nanomed Biotechnol. 1-8. Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):305-312. doi: 10.3109/21691401.2016.1147452. Epub 2016 Feb 28.
[2] Paula Costales et. Al. K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 290(24), 14852-14865 (2015).
分子式 C27H46O |
分子量 386.65 |
CAS号 57-88-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO < 1 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT01782027 | Cholesterol, HDL|Lipid Metabolism, Inborn Errors|Tangier Disease|LCAT Deficiency|Cholesteryl Ester Transfer Protein (CETP) Deficiency | Drug: 3H-cholesterol bound to albumin | University of Pennsylvania | 2012-10-01 | 2016-07-29 | |
NCT01958216 | Occlusion of Bile Duct With an External Bile Diversion. | Other: Intravenous injection of deuterated cholesterol diluted in intralipid 20% | Nantes University Hospital | 2013-09-01 | 2013-10-08 | |
NCT01138787 | Cholesterol Absorption Inhibition. | Dietary Supplement: Reference spread|Dietary Supplement: Placebo spread|Dietary Supplement: Test spread | Unilever R&D|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 2010-06-01 | 2011-06-15 | |
NCT02068248 | LDL Cholesterol | Dietary Supplement: Soluble Fibre | St. Michael's Hospital, Toronto | 2014-01-01 | 2016-11-07 | |
NCT00114634 | Smith-Lemli-Opitz Syndrome | Dietary Supplement: Egg yolk preparation with cholesterol|Dietary Supplement: Egg substitute, without cholesterol | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2005-06-01 | 2015-12-24 |
NCT02549144 | Lipids | Dietary Supplement: Low versus high fat/cholesterol diet | Azienda Ospedaliero, Universitaria Pisana | 2015-12-01 | 2015-11-16 | |
NCT01773278 | Smith-Lemli-Opitz Syndrome|Cone-Rod Dystrophy|Hearing Loss | Drug: Antioxidants|Drug: Cholesterol | University of Colorado, Denver | 2008-12-01 | 2016-08-18 | |
NCT01356420 | Smith-Lemli-Opitz Syndrome | Dietary Supplement: Cholesterol supplementation | Oregon Health and Science University | 2011-01-01 | 2012-09-18 | |
NCT01634646 | Overweight|Elevated Cholesterol | Dietary Supplement: Lyzme5 | Jeff Golini|All American Pharmaceutical | 2012-05-01 | 2013-07-12 | |
NCT01890031 | Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors|Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors | Other: Interactive Cholesterol Advisory Tool|Other: Study physician visits | University of Rochester | Phase 1 | 2012-01-01 | 2015-08-05 |
NCT00765284 | HDL Cholesterol | KineMed | 2007-12-01 | 2011-06-29 | ||
NCT01004705 | Elevated LDL Cholesterol | Drug: Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril),|Drug: Simvastatin | Ferrer Internacional S.A. | Phase 2 | 2009-09-01 | 2012-07-31 |
NCT00652301 | Cholesterol | Drug: ezetimibe|Drug: Comparator: Placebo (unspecified)|Drug: simvastatin | Merck Sharp & Dohme Corp.|Schering-Plough | Phase 3 | 2003-07-01 | 2017-03-07 |
NCT02779673 | LDL-cholesterol Level 130-159mg/dL | Other: Yoghurt drink containing plant stanol as esters|Other: Yoghurt drink without plant stanol as esters | Yonsei University | 2014-07-01 | 2016-05-19 | |
NCT01031862 | Healthy | Other: 3H-Cholesterol | University of Pennsylvania|Bristol-Myers Squibb | 2009-11-01 | 2010-06-24 | |
NCT01362218 | Elevated LDL Cholesterol | Drug: Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril)|Drug: Simvastatin, ramipril, acetylsalicylic acid | Ferrer Internacional S.A. | Phase 2 | 2010-10-01 | 2013-04-23 |
NCT01930149 | Cardiovascular Diseases|Lipid Testing|Primary Prevention of Cardiovascular Disease | Behavioral: Mailed patient outreach intervention | Northwestern University|Agency for Healthcare Research and Quality (AHRQ) | 2013-12-01 | 2014-09-26 | |
NCT00272844 | Smith-Lemli-Opitz Syndrome | Drug: crystalline cholesterol oil-based suspension | Boston Children鈥檚 Hospital | Phase 1|Phase 2 | 1998-01-01 | 2011-07-13 |
NCT00999453 | Hypercholesterolemia | Other: LDL-cholesterol | Clinical Research Center for End Stage Renal Disease, Korea|Ministry of Health & Welfare, Korea | 2009-10-01 | 2017-03-15 | |
NCT00328211 | Healthy | Dietary Supplement: Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic)|Dietary Supplement: Sphingomyelin|Drug: Pluronic F-68|Other: C13 Stable isotope of Cholesterol | Children's Hospital Medical Center, Cincinnati|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2005-09-01 | 2016-12-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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