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Cholesterol

胆固醇

Cholesterol是哺乳动物中主要的甾体类化合物,在基本的细胞生命活动中起到重要作用。

目录号
EY0289
EY0289
EY0289
纯度
99.49%
99.49%
99.49%
规格
25 mg
50 mg
100 mg
原价
180
286
420
售价
180
286
420
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Alomrani AH,et al. Alomrani, AH. et al. 2016. Flexosomes for transdermal delivery of meloxicam: characterization and antiinflammatory activity. Artif Cells Nanomed Biotechnol. 1-8. Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):305-312. doi: 10.3109/21691401.2016.1147452. Epub 2016 Feb 28.
    [2] Paula Costales et. Al. K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 290(24), 14852-14865 (2015).

    分子式
    C27H46O
    分子量
    386.65
    CAS号
    57-88-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    < 1 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT01782027 Cholesterol, HDL|Lipid Metabolism, Inborn Errors|Tangier Disease|LCAT Deficiency|Cholesteryl Ester Transfer Protein (CETP) Deficiency Drug: 3H-cholesterol bound to albumin University of Pennsylvania 2012-10-01 2016-07-29
    NCT01958216 Occlusion of Bile Duct With an External Bile Diversion. Other: Intravenous injection of deuterated cholesterol diluted in intralipid 20% Nantes University Hospital 2013-09-01 2013-10-08
    NCT01138787 Cholesterol Absorption Inhibition. Dietary Supplement: Reference spread|Dietary Supplement: Placebo spread|Dietary Supplement: Test spread Unilever R&D|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 2010-06-01 2011-06-15
    NCT02068248 LDL Cholesterol Dietary Supplement: Soluble Fibre St. Michael's Hospital, Toronto 2014-01-01 2016-11-07
    NCT00114634 Smith-Lemli-Opitz Syndrome Dietary Supplement: Egg yolk preparation with cholesterol|Dietary Supplement: Egg substitute, without cholesterol Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Phase 2 2005-06-01 2015-12-24
    NCT02549144 Lipids Dietary Supplement: Low versus high fat/cholesterol diet Azienda Ospedaliero, Universitaria Pisana 2015-12-01 2015-11-16
    NCT01773278 Smith-Lemli-Opitz Syndrome|Cone-Rod Dystrophy|Hearing Loss Drug: Antioxidants|Drug: Cholesterol University of Colorado, Denver 2008-12-01 2016-08-18
    NCT01356420 Smith-Lemli-Opitz Syndrome Dietary Supplement: Cholesterol supplementation Oregon Health and Science University 2011-01-01 2012-09-18
    NCT01634646 Overweight|Elevated Cholesterol Dietary Supplement: Lyzme5 Jeff Golini|All American Pharmaceutical 2012-05-01 2013-07-12
    NCT01890031 Low Risk (0-10% Chance) of Developing Cardiovascular Disease Within 10 Years Based on Risk Factors|Moderate Risk (10-20% Chance) of Developing Cardiovascular (Heart) Disease Within 10 Years Based on Risk Factors Other: Interactive Cholesterol Advisory Tool|Other: Study physician visits University of Rochester Phase 1 2012-01-01 2015-08-05
    NCT00765284 HDL Cholesterol KineMed 2007-12-01 2011-06-29
    NCT01004705 Elevated LDL Cholesterol Drug: Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril),|Drug: Simvastatin Ferrer Internacional S.A. Phase 2 2009-09-01 2012-07-31
    NCT00652301 Cholesterol Drug: ezetimibe|Drug: Comparator: Placebo (unspecified)|Drug: simvastatin Merck Sharp & Dohme Corp.|Schering-Plough Phase 3 2003-07-01 2017-03-07
    NCT02779673 LDL-cholesterol Level 130-159mg/dL Other: Yoghurt drink containing plant stanol as esters|Other: Yoghurt drink without plant stanol as esters Yonsei University 2014-07-01 2016-05-19
    NCT01031862 Healthy Other: 3H-Cholesterol University of Pennsylvania|Bristol-Myers Squibb 2009-11-01 2010-06-24
    NCT01362218 Elevated LDL Cholesterol Drug: Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril)|Drug: Simvastatin, ramipril, acetylsalicylic acid Ferrer Internacional S.A. Phase 2 2010-10-01 2013-04-23
    NCT01930149 Cardiovascular Diseases|Lipid Testing|Primary Prevention of Cardiovascular Disease Behavioral: Mailed patient outreach intervention Northwestern University|Agency for Healthcare Research and Quality (AHRQ) 2013-12-01 2014-09-26
    NCT00272844 Smith-Lemli-Opitz Syndrome Drug: crystalline cholesterol oil-based suspension Boston Children鈥檚 Hospital Phase 1|Phase 2 1998-01-01 2011-07-13
    NCT00999453 Hypercholesterolemia Other: LDL-cholesterol Clinical Research Center for End Stage Renal Disease, Korea|Ministry of Health & Welfare, Korea 2009-10-01 2017-03-15
    NCT00328211 Healthy Dietary Supplement: Bile Acids (Cholic, Ursodeoxycholic, Chenodeoxycholic)|Dietary Supplement: Sphingomyelin|Drug: Pluronic F-68|Other: C13 Stable isotope of Cholesterol Children's Hospital Medical Center, Cincinnati|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2005-09-01 2016-12-06

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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