Adenine

腺嘌呤

Adenine (腺嘌呤) 是嘌呤衍生物,为抗代谢类核苷类似物。是一种核酸碱基,具有多种生化作用。

目录号
EY0287
EY0287
EY0287
纯度
99.76%
99.76%
99.76%
规格
50 mg
100 mg
500 mg
原价
112
150
280
售价
112
150
280
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Cristiene Okabe et. Al. NF-κB activation mediates crystal translocation and interstitial inflammation in adenine overload nephropathy. American Journal of Physiology: Renal, Fluid & Electrolyte Physiology (Abstracts), 305(2), F155-F163 (2013).
    [2] E M Ungerfeld et. Al. Attempts to inhibit ruminal methanogenesis by blocking pyruvate oxidative decarboxylation. Canadian Journal of Microbiology/Revue Canadienne de Microbiologie, 49(10), 650-654 (2003).

    分子式
    C5H5N5
    分子量
    135.13
    CAS号
    73-24-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT02950441 Aging Dietary Supplement: Nicotinamide Riboside|Other: Placebo University of Birmingham Early Phase 1 2016-06-01 2016-11-04
    NCT00002115 HIV Infections Drug: Adefovir Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT00002128 HIV Infections Drug: Adefovir dipivoxil Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT00002396 HIV Infections Drug: Tenofovir disoproxil fumarate Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT02752633 Adenine Phosphoribosyltransferase Deficiency Drug: Allopurinol|Drug: Febuxostat Landspitali University Hospital|Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 4 2013-05-01 2016-04-22
    NCT00000843 HIV Infections Drug: Adefovir dipivoxil National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2005-06-23
    NCT00002180 HIV Infections Drug: Tenofovir Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT02689882 Metabolic Disturbance Dietary Supplement: nicotinamide riboside University of Washington|National Heart, Lung, and Blood Institute (NHLBI) Phase 1 2015-11-01 2016-02-18
    NCT00002346 HIV Infections Drug: Adefovir dipivoxil Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT00002326 HIV Infections Drug: Adefovir|Drug: Zidovudine Gilead Sciences|NIH AIDS Clinical Trials Information Service Phase 1 null 2005-06-23
    NCT02942888 Mild Cognitive Impairment|NAD Dietary Supplement: Nicotinamide riboside|Dietary Supplement: Sugar Pill The University of Texas Health Science Center at San Antonio|University of Texas|South Texas Veterans Health Care System 2016-10-01 2016-10-24
    NCT02780297 Hyperoxaluria|Cystinuria|Dent Disease|Lowe Syndrome|Adenine Phosphoribosyltransferase Deficiency Mayo Clinic 2016-05-01 2016-09-19
    NCT01485315 Septic Shock Biological: SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion|Biological: SAGM (Saline-Adenine-Glucose-Mannitol) blood transfusion Scandinavian Critical Care Trials Group|Copenhagen Trial Unit, Center for Clinical Intervention Research|Rigshospitalet, Denmark|University of Copenhagen Phase 3 2011-11-01 2014-10-02
    NCT00561496 HIV Infections Drug: Tenofovir gel CONRAD|International Partnership for Microbicides, Inc.|Gilead Sciences Phase 1 2007-03-01 2008-05-27
    NCT00708721 Cancer|Chronic Myelomonocytic Leukemia Drug: Clofarabine University of Utah|Genzyme, a Sanofi Company Phase 1|Phase 2 2008-03-01 2015-01-15
    NCT00594373 HIV Infections Drug: Tenofovir gel|Drug: Tenofovir gel placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2013-09-23
    NCT00580723 Acne Rosacea Other: PRK 124 University of California, Irvine|SenetekPLC Phase 1|Phase 2 2007-04-01 2013-12-16
    NCT02026388 Primary Hyperoxaluria|Dent Disease|APRT Deficiency|Cystinuria Mayo Clinic 2013-05-01 2016-07-05
    NCT02921659 Aging Dietary Supplement: Niagen鈩Dietary Supplement: Placebo University of Colorado, Boulder|ChromaDex, Inc. Phase 1|Phase 2 2015-04-01 2016-11-29
    NCT01581736 Obesity|Type 2 Diabetes Mellitus Drug: U100 Humulin|Other: Exercise Mayo Clinic|Arizona State University 2012-04-01 2016-05-06








    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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