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Lornoxicam

氯诺昔康,Chlortenoxicam,Chlortenoxicam,Xefo,Ro 13-9297,TS110

Lornoxicam是高活性COX-1和COX-2抑制剂，IC50分别为5nM和8nM，是一个新型非甾体抗炎化合物。

目录号
EY0272
EY0272
EY0272
纯度
99.19%
99.19%
99.19%
规格
100 mg
200 mg
500 mg
原价
455.00
678.00
1400
售价
455.00
678.00
1400
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ali Irfan Guzel et. al. Comparative effect of lornoxicam and paracetamol in pain relief in endometrial sampling. Journal of Experimental Therapeutics and Oncology, 9(4), 317-320 (2012).
    [2] N M Skjodt and N M Davies. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam. Clinical Pharmacokinetics, 34(6), 421-428 (1998).
    [3] Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994).
    [4] Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988).

    分子式
    C13H10ClN3O4S2    		 分子量
    371.82    		 CAS号
    70374-39-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    2 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00997750 Acute Coronary Syndrome Drug: Lornoxicam Central Clinical Hospital with Outpatient Health Center of Business Administration for the President of Russian Federati Phase 4 2007-03-01 2009-10-18
    NCT02750917 Postoperative Pain Drug: Lornoxicam|Drug: Etoricoxib Foisor Orthopedics Clinical Hospital Phase 3 2014-09-01 2016-04-25
    NCT01117948 Alzheimers Disease Drug: Lornoxicam|Drug: Placebo JSW Lifesciences Phase 2 2009-09-01 2013-02-01
    NCT01055470 Osteoarthritis of Knee Joint Drug: Diclofenac|Drug: Lornoxicam Government Medical College, Bhavnagar 2008-12-01 2010-01-22
    NCT01069055 Inguinal Hernia|Postoperative Pain Other: Sterile Saline|Drug: Intravenous lornoxicam|Drug: Intravenous paracetamol Diskapi Teaching and Research Hospital Phase 3 2010-02-01 2010-02-23
    NCT01564680 Postoperative Pain Other: placebo|Drug: Paracetamol|Drug: Lornoxicam Dammam University Phase 4 2009-03-01 2012-03-27
    NCT03038321 Non-Muscle-invasive Bladder Cancer (NMIBC)|Bacillus Calmette-Guerin (BCG) Cystitis|Intra-vesical Instillation Drug: sofenacin|Drug: Tavanic|Drug: Xefo Mansoura University Phase 4 2017-02-01 2017-03-20
    NCT00293631 Bunionectomy|Orthopedic Surgery Drug: Lornoxicam 8 mg|Drug: Lornoxicam 16 mg|Drug: Ketorolac 30 mg|Drug: Placebo POZEN Phase 2 2005-11-01 2012-11-29
    NCT00293657 Headache (Migraine) Drug: Lornoxicam 8 mg|Drug: Lornoxicam 16 mg|Drug: Placebo POZEN Phase 2 2005-12-01 2012-11-29
    NCT01718756 Closed Non Comminuted Long Bone Fractures Drug: Placebo|Drug: Continuous infusion|Drug: Scheduled Mansoura University Phase 1|Phase 2 2013-06-01 2015-03-15
    NCT01480752 Post Operative Endodontic Pain Drug: Lornoxicam|Drug: normal saline|Drug: no injection Islamic Azad University, Tehran Phase 2 2011-09-01 2013-01-11
    NCT02025166 Pain Drug: Paracetamol|Drug: lornoxicam Rambam Health Care Campus 2014-01-01 2013-12-30
    NCT02749162 Postoperative Pain Drug: Dexamethasone phosphate|Drug: Paracetamol|Drug: Morphine|Drug: Lidocaine|Drug: Ropivacaine Foisor Orthopedics Clinical Hospital Phase 3 2015-11-01 2016-08-09
    NCT02698995 Postoperative Pain Drug: Dexamethasone|Drug: Ropivacaine|Drug: Paracetamol|Drug: Morphine|Drug: Lidocaine Foisor Orthopedics Clinical Hospital Phase 3 2015-11-01 2016-08-09
    NCT01638962 Osteoarthritis, Knee Drug: Instruction on analgesic use for pain relief (acetaminophen and NSAIDs)|Other: Neuromuscular exercise University of Southern Denmark|Odense University Hospital|Region Syddanmark|The Danish Rheumatism Association|Association of Danish Physiotherapists 2012-08-01 2016-08-01

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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