生物活性

Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia

体外研究

Magnesium sulfate (3 mM) 可抑制培养的子宫肌层细胞中磷脂酰肌醇-4,5-二磷酸特异性磷脂酶 C 活性和随后的钙释放。

Magnesium sulfate (20 mM; 6 小时) 可抑制 RAW264.7 细胞中 LPS 诱导的炎症分子的产生和 NF-κB 的活化。

Time qPCR

Cell Line: RAW264.7 cells treated with 100 ng/mL of LPS 
Concentration: 20 mM
Incubation Time: 6 h
Result: Inhibtied the levels of iNOS and COX-2.

体内研究

Magnesium sulfate (腹腔注射; 270 mg/kg, 随后每 20 分钟注射 27 mg/kg, 持续 4 小时, 最后再注射 270 mg/kg) 可减轻 LPS 引起的胎鼠炎症相关脑损伤。

Animal Model: CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15
Dosage: 270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
Administration: Intraperitoneal injection
Result: Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.

激酶实验

细胞实验

动物实验

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

1.Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56(6):566-74.
2.Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202(3):292.e1-9.

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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