The multifunctional and redox-sensitive HMGB1/HMG-1 protein plays multiple roles in cellular compartments. In the nucleus, it serves as a major chromatin-associated non-histone protein involved in key processes such as replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair, and genome stability. Animal-Free HMGB1/HMG-1 Protein, Human (His) is the recombinant human-derived animal-FreeHMGB1/HMG-1 protein, expressed by E. coli , with C-His, C-His labeled tag. The total length of Animal-Free HMGB1/HMG-1 Protein, Human (His) is 215 a.a., with molecular weight of ~25.70 kDa.
Measure by its ability to induce TNF alpha in RAW264.7 cells. The ED50 for this effect is <10 μg/mL.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
分子式 |
分子量 Approximately 25.70 kDa |
CAS号 |
储存方式 -20°C |
溶剂(常温) |
DMSO |
Water |
Ethanol |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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