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生物活性
Allicin, an active compound of garlic, is unstable in aqueous solution without formic acid. It rapidly decomposes mainly to diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene. DATS and DADS act as donors of H2S donors, which plays a cell signaling role similar to NO and CO. Allicin exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Additionally, allicin inhibits telomerase activity and inducible nitric oxide synthase (iNOS; NOS II) expression and promotes apoptosis.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Ankri, S., et al., 1997. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrobial agents and chemotherapy. 41(10): 2286-8. PMID: 9333064
[2] Dirsch, V M., et al., 1998. Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase. Atherosclerosis. 139(2): 333-9. PMID: 9712340
分子式
C6H10OS2 |
分子量
162.27 |
CAS号
539-86-6 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
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DMSO
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Water
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Ethanol
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体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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