生物活性

体外研究

Ceruletide is similar chemically and biologically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction, pancreatic exocrine secretion, gastric secretion, and motility in the distal duodenum, jejunum, ileum and colon, while delaying gastric emptying and inhibiting motility in the proximal duodenum. NF-kappaB/Rel is rapidly activated during cerulein pancreatitis. This activation may induce a self-defending genetic program before the onset of cellular injury, which might prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation.

体内研究

激酶实验

1.The peptide is to be dissolved in distilled, oxygen free or preferable sterile oxygen free water first. The concentration should be high enough to allow addition of buffer after the products is dissolved completely.


2.If necessary diluted acetic acid or ammonium hydroxide, app. 1%, can be added to help solubilize the peptide. In those rare cases where solubilization is still not achieved, the solution may be sonicated briefly (up to 10 min, temperature shouldnt rise over 30-40oC)


3.In order to avoid serious solubility problems, buffer or saline should be added after the peptide is fully in solution.


4.Solutions should be kept slightly basic to avoid degradation.


5.Solutions limited lifetime in solution and long-term storage is not recommended.
Note: Product supplied as a trifluoroacetate salt.

细胞实验

动物实验

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] 1Maria Dolors Sans etc., Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F. GIastrointestinal and liver physiology,August 2003 vol. 285 no. 3 G517-G528.
[2] Warzecha Z etc., Effect of sensory nerves and CGRP on the development of caerulein-induced pancreatitis and pancreatic recovery. J Physiol Pharmacol. 2001 Dec;52(4 Pt 1):679-704.
[3] Adel Galal El-Shemi etc., Interleukin-22 therapy attenuates the development of acute pancreatitis in rats. World J Gastroenterol. 2003 Mar;9(3):584-9.

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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