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生物活性
MelatoninAntimycin A is an antibiotic that induces apoptosis and inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C1. Additionally, studies report that antimycin A causes damage to mitochondrial DNA, lipids, and proteins in cells treated with the antibiotic. The compound has been shown to mimic cell-death-inducing Bcl-2 homology domain 3 and has been applied as a reactive oxygen species (ROS) generator to study biological systems. Research indicates that antimycin A inhibits the cell growth of HeLa cells through apoptosis and blocks nitric oxide-induced apoptosis via inhibition of cytochrome C leakage.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Nicole S Hou et. al. Proceedings of the National Academy of Sciences of the United States of America, 111(111), undefined (2014-5-21).
[2] Oded Shaham et. al. Proceedings of the National Academy of Sciences of the United States of America, 107(107), undefined (2010-1-19).
分子式
C13H14O5 |
分子量
250.25 |
CAS号
1397-94-0 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
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DMSO
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Water
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Ethanol
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体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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