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生物活性
Adenosine 3',5'-cyclic monophosphate (cAMP) is an important second messenger and intracellular regulator in many biological processes and, in particular, is used in intracellular signal transduction to convey the cAMP-dependent pathway. cAMP is derived from ATP and is an adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. In eukaryotic cells, cAMP function in many biochemical processes, including the regulation of glycogen, lipid and sugar metabolism. In these roles, cAMP works by activating PKA (protein kinase A). Additionally, cAMP works independently of PKA in activating calcium channels and proving a pathway for the release of growth hormone.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Spada, A., et al. 1997. Horm. Res. 47: 235-239.
[2] Daniel, P.B., et al. 1998. Annu. Rev. Nutr. 18: 353-383.
[3] Chen, T.C., et al. 1998. Lab. Invest. 78: 165-174.
分子式
C10H12N5O6P |
分子量
329.21 |
CAS号
60-92-4 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
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DMSO
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Water
50 mg/mL |
Ethanol
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体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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