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Wedelolactone

Wedelolactone is a multi-target natural plant coumestan exhibiting cytotoxicity towards cancer cells. Wedelolactone acts as an inhibitor of chymotrypsin-like, trypsin-like, and caspase-like activities of proteasome in breast cancer cells.

目录号
EY2826
EY2826
EY2826
EY2826
纯度
98.79%
98.79%
98.79%
98.79%
规格
1 mg
5 mg
10 mg
20 mg
原价
360
800
1400
2100
售价
360
800
1400
2100
库存
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  • 生物活性

    Wedelolactone acts as an inhibitor of chymotrypsin-like, trypsin-like, and caspase-like activities of proteasome in breast cancer cells. The proteasome inhibitory effect of wedelolactone was documented by (i) reduced cleavage of fluorogenic proteasome substrates; (ii) accumulation of polyubiquitinated proteins and proteins with rapid turnover in tumor cells; and (iii) molecular docking of wedelolactone into the active sites of proteasome catalytic subunits. Inhibition of proteasome by wedelolactone was independent on its ability to induce reactive oxygen species production by redox cycling with copper ions, suggesting that wedelolactone acts as copper-independent proteasome inhibitor.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Melo, P.A. and Ownby, C.L. 1999. Toxicon. 37: 199-215.
    [2] Syed, S.D., et al. 2003. Phytother Res. 17: 420-421.
    [3] Kobori, M., et al. 2004. Cell Death Differ. 11: 123-130.

    分子式
    C16H10O7    		 分子量
    314.25    		 CAS号
    524-12-9    		 储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂（常温）
    		 DMSO
    Soluble    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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