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Angiotensin II

Angiotensin II human; Hypertensin II; Ang II; DRVYIHPF

Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

目录号
EY2824
EY2824
EY2824
纯度
98.90%
98.90%
98.90%
规格
5 mg
10 mg
50 mg
原价
480
780
1800
售价
480
780
1800
库存
现货
现货
现货
订购
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  • 生物活性

    The angiotensin II type 1 receptor (AT1 receptor) is one of the key players in the renin angiotensin aldosterone system. The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage. Accumulating evidence shows the complex picture of AT1 receptor-mediated signaling; AT1 receptor-mediated heterotrimeric G protein-dependent signaling, transactivation of growth factor receptors, NADPH oxidase and ROS signaling, G protein-independent signaling, including the β-arrestin signals and interaction with several AT1 receptor interacting proteins.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90 581.
    [2] Clayton et al (1998) Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetised rat. Br.J.Pharmacol. 124 1467.
    [3] Mosequeda-Garcia et al (1990) Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. J.Pharmacol.Exp.Ther.255 374.

    分子式
    C50H71N13O12
    分子量
    1046.18
    CAS号
    4474-91-3
    储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂(常温)
    DMSO
    Water
    Soluble
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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