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生物活性
Colistin sulfate, a cationic polypeptide from the polymyxin family, has been shown to be an extremely potent antibiotic that is effective against most gram-negative Bacilli. Mechanistic studies have reported that this compound induces apoptosis through interaction with the cytoplasmic membrane. Additional studies have demonstrated that Colistin sulphate is extremely toxic. Toxic effects noted include neurotoxicity, nephrotoxicity, vascular congestion of brain vessels, and extreme kidney and CNS negative effects.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Beringer, P. 2001. Curr Opin Pulm Med. 7: 434-440.
[2] Evans, M.E., et al. 1999. Ann Pharmacother. 33: 960-967.
[3] Landman, W.J., et al. 2000. Avian Pathol. 29: 593-601.
分子式
C104H206N32O46S5 |
分子量
2801.27 |
CAS号
1264-72-8 |
储存方式
-20 ℃长期冷藏储存。冰袋运输 |
溶剂（常温）
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DMSO
<1 mg/mL |
Water
100 mg/mL |
Ethanol
<1 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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