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生物活性
Disodium Cromoglycate is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.Disodium Cromoglycate is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.Disodium Cromoglycate is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Vural, K.M., et al., Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model. Ann. Thorac. Surg. 69, 228-232, (2000)
[2] Norris, A.A., Pharmacology of sodium cromoglycate. Clin. Exp. Allergy 26, 5-7, (1996)
分子式
C23H14Na2O11 |
分子量
512.33 |
CAS号
15826-37-6 |
储存方式
-20 ℃长期冷藏储存。冰袋运输 |
溶剂（常温）
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DMSO
<1 mg/mL |
Water
4 mg/mL |
Ethanol
<1 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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