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Nafarelin Acetate

Nafarelin is a gonadotropin-releasing hormone (GnRH) agonists that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

目录号
EY2775
EY2775
EY2775
纯度
98.73%
98.73%
98.73%
规格
10 mg
25 mg
50 mg
原价
980
1,690
2,080
售价
980
1,690
2,080
库存
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Nafarelin is a gonadotropin-releasing hormone (GnRH) agonists that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Nafarelin can Induce atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia. Nafarelin decreases or ablates the physical symptoms associated with endometriosis, and pregnancy rates.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Mizutani T et al. Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. Int J Fertil Menopausal Stud. 1995 Mar-Apr;40(2):106-11.
    [2] Chrisp P et al. Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions. Drugs. 1990 Apr;39(4):523-51.

    分子式
    C66H83N17O13
    分子量
    1322.48
    CAS号
    76932-56-4
    储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂(常温)
    DMSO
    Soluble
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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