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生物活性
Fusidic acid sodium salt, a triterpenoid compound, displays a capacity to inhibit lysis of isolated islet cells by activated microphages via suppression of nitiric oxide toxicity. Other studies have shown Furisdic acid to have immunomodulatory effects related to decrease in cytokine production in animal models of insuln dependent diabetes and septic shock. In vitro studies suggest that Furisdic acid acts against many pathogens including Staphylococcus aureus, gram-positive anaerobic bacteria, Neisseria spp., Bordetella pertussis, and Moraxella catarrhalis. In addition, this compound has been noted to inhibit the function of neutrophils and T-lymphocytes. The mechanism behind these inhibitions is known to be due to interference of protein synthesis via suppression of EF-G (elongation factor G) at the level of the ribosome.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Collignon, P., et al. 1999. Int. J. Antimicrob. Agents. 12: S45-S58.
[2] Howden, B.P. and Grayson, M.L. 2006. Clin. Infect. Dis. 42: 394-400.
分子式
C31H47NaO6 |
分子量
538.69 |
CAS号
751-94-0 |
储存方式
-20 ℃长期冷藏储存。冰袋运输 |
溶剂（常温）
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DMSO
100 mg/mL |
Water
100 mg/mL |
Ethanol
100 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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