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Dantrolene sodium

Dantrolene sodium hydrate

Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm.

目录号
EY2728
EY2728
EY2728
纯度
99.67%
99.67%
99.67%
规格
50 mg
100 mg
500 mg
原价
360
600
1760
售价
360
600
1760
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Dantrolene Sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene Sodium, is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Additionally, Dantrolene Sodium, has been shown to inhibit G6PD, RyR-1 and RyR-3 in vitro.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Tanii, H., et al., 1997. Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA-binding activity in the rabbit brain following haloperidol administration and heat stress. Psychiatry and clinical neurosciences. 51(6): 415-9.
    [2] Büyükokuroğlu, M E., et al., 2001. In vitro antioxidant properties of dantrolene sodium. Pharmacological research : the official journal of the Italian Pharmacological Society. 44(6): 491-4.

    分子式
    C20H26N2O2
    分子量
    399.29
    CAS号
    24868-20-0
    储存方式
    -20 ℃长期冷藏储存。冰袋运输
    溶剂(常温)
    DMSO
    >12 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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