Folic acid(Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
Folic Acid is an important cofactor in the transfer of one-carbon moieties and plays big role in formation of S-adenosyl methionine and in the synthesis and repair of DNA and RNA. Folate depletion causes disruption of DNA integrity and repair enhancing carcinogenesis by altering expression of critical tumor suppressor genes. Folic Acid is a substrate of DHFR.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kim YI. Nutr. Rev. 57:314-21 (1999).
[2] Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI. Cancer Res. 60:3191-9 (2000).
[3] Choi SW, Mason JB. J. Nutr. 130:129-32 (2000).
分子式 C19H19N7O6 |
分子量 441.40 |
CAS号 59-30-3 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 4 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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