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生物活性
Piperazine is frequently found in biologically active compounds across a number of different therapeutic areas. Some therapeutic areas include antifungals, antidepressants, antiviral, and serotonin receptor (5-HT) antagonists/agonists. Has been used since the 1950's as an anthelmintic, especially in horses and dogs. The anthelmintic properties of piperazine compounds is by paralysis of the parasites; this action is mediated by its agonistic effects on the GABA receptor. Wide variety of additional applications include use as an intermediate for pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Blechschmidt, B., et al. 1992. J. Gen. Microbiol. 138: 1197-1202.
[2] Jones, R.G., et al. 2002. J. Immunol. Methods. 263: 57-74.
[3] Constanti A, et al. Br J Pharmacol. 1976, 57(3):347-58.
分子式
C4H10N2 |
分子量
86.14 |
CAS号
110-85-0 |
储存方式
-20 ℃长期冷藏储存。冰袋运输 |
溶剂（常温）
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DMSO
8 mg/mL warmed |
Water
<1 mg/mL |
Ethanol
<1 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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