Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] A C Barnes,et al. In vitro susceptibility of the fish pathogen Aeromonas salmonicida to flumequine. Antimicrob Agents Chemother. 1991 Dec; 35(12): 2634–2635.
[2] D Greenwood. Activity of flumequine against Escherichia coli: in vitro comparison with nalidixic and oxolinic acids.Antimicrob Agents Chemother. 1978 Mar; 13(3): 479–483.
分子式 C14H12FNO3 |
分子量 261.25 |
CAS号 42835-25-6 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 3 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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