Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Masato Ikeda,et al. Development of Biotin-Prototrophic and -Hyperauxotrophic Corynebacterium glutamicum Strains. Appl Environ Microbiol. 2013 Aug; 79(15): 4586–4594. doi: 10.1128/AEM.00828-13.
[2] Anna Bogusiewicz,et al. In HepG2 Cells, Coexisting Carnitine Deficiency Masks Important Indicators of Marginal Biotin Deficiency. J Nutr. 2015 Jan; 145(1): 32–40. Published online 2014 Nov 19. doi: 10.3945/jn.114.201343.
分子式 C10H16N2O3S |
分子量 244.31 |
CAS号 58-85-5 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO >30 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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