Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Pavel Starkov and Tom D Sheppard. Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides. Organic & Biomolecular Chemistry, 9(5), 1320-1323 (2011).
[2] Glyn Chidlow,et al. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical synaptosomes by direct interaction with Na+ channels: comparison with other β-adrenoceptor antagonists. Br J Pharmacol. 2000 Jun; 130(4): 759–766. doi: 10.1038/sj.bjp.0703369.
[3] C.A. Rudoy, E.J. Van Bockstaele. Betaxolol, a selective β1-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats. Prog Neuropsychopharmacol Biol Psychiatry. Author manuscript; available in PMC 2015 Jan 8. Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30; 31(5): 1119–1129. Published online 2007 Apr 19. doi: 10.1016/j.pnpbp.2007.04.005.
分子式 C18H29NO3 |
分子量 307.43 |
CAS号 659-18-7 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 62 mg/mL |
Water 62 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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