Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Stephanie K. Bunt,et al. Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. Cancer Immunol Immunother. Author manuscript; available in PMC 2014 Feb 1. Published in final edited form as: Cancer Immunol Immunother. 2013 Feb; 62(2): 10.1007/s00262-012-1324-3. Published online 2012 Aug 5. doi: 10.1007/s00262-012-1324-3.
[2] Eui-Sic Cho,et al. The Effects of Rosiglitazone on Osteoblastic Differentiation, Osteoclast Formation and Bone Resorption. Mol Cells. 2012 Feb 29; 33(2): 173–181. Published online 2012 Jan 26. doi: 10.1007/s10059-012-2240-z.
分子式 C18H20ClN3O3S |
分子量 393.89 |
CAS号 302543-62-0 |
储存方式 -20 ℃长期冷藏储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water <1 mg/mL |
Ethanol 200 mM |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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